DA-32-QL71_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, Namodenoson, Adenosine A3 Agonists targeting ADORA3 (Novartis, 3035850)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3035850
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Genes

104 genes differentially expressed following the DA-32-QL71_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MMP9 matrix metallopeptidase 9 2.15334
KISS1 KiSS-1 metastasis-suppressor 1.87775
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 1.73476
TIMP1 TIMP metallopeptidase inhibitor 1 1.66279
TGM2 transglutaminase 2 1.47988
ITGB5 integrin, beta 5 1.31858
SAA2 serum amyloid A2 1.05004
HDAC5 histone deacetylase 5 0.903219
MRPL13 mitochondrial ribosomal protein L13 0.820459
HMGA1 high mobility group AT-hook 1 0.818847
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.814228
CTSB cathepsin B 0.781772
SCG5 secretogranin V 0.705665
NNMT nicotinamide N-methyltransferase 0.697164
HRNR hornerin 0.650565
RPS5 ribosomal protein S5 0.607049
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.536704
PDZK1IP1 PDZK1 interacting protein 1 0.528359
FKBP1A FK506 binding protein 1A, 12kDa 0.50563
SAA2-SAA4 SAA2-SAA4 readthrough 0.486516
GUK1 guanylate kinase 1 0.484657
CLEC11A C-type lectin domain family 11, member A 0.447235
RPL18A ribosomal protein L18a 0.416278
MT2A metallothionein 2A 0.403454
SQSTM1 sequestosome 1 0.403199
RACK1 receptor for activated C kinase 1 0.390042
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.387894
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.387498
KRT18 keratin 18, type I 0.376535
TNIP1 TNFAIP3 interacting protein 1 0.370057
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.358799
CD59 CD59 molecule, complement regulatory protein 0.342145
SPHK1 sphingosine kinase 1 0.337066
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.33447
PFN1 profilin 1 0.33447
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 0.332188
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.33108
RPS15 ribosomal protein S15 0.329131
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.327864
SELENOM selenoprotein M 0.327511
SSR4 signal sequence receptor, delta 0.322758
MVP major vault protein 0.318311
LINC02762 long intergenic non-protein coding RNA 2762 0.317777
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.316388
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.309768
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.308715
SERF2 small EDRK-rich factor 2 0.308715
MT1H metallothionein 1H 0.308715
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.305143
YPEL3 yippee-like 3 (Drosophila) 0.301853
RHOC ras homolog family member C 0.301
MFSD2B major facilitator superfamily domain containing 2B 0.274532
RPS13 ribosomal protein S13 0.274532
RPL15 ribosomal protein L15 0.268207
IL32 interleukin 32 0.255437
RPL28 ribosomal protein L28 0.238813
PRAF2 PRA1 domain family, member 2 0.220588
GPR176 G protein-coupled receptor 176 0.208172
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 0.20619
CIB1 calcium and integrin binding 1 (calmyrin) 0.201504
SLC25A39 solute carrier family 25, member 39 0.201303

decreased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked -2.07394
TPM1 tropomyosin 1 (alpha) -1.77832
TAGLN transgelin -1.37375
KRT75 keratin 75, type II -1.35054
KRT17 keratin 17, type I -1.15213
CPA4 carboxypeptidase A4 -0.879941
S100A10 S100 calcium binding protein A10 -0.793282
MAGED1 melanoma antigen family D1 -0.578253
MARCKSL1 MARCKS-like 1 -0.547093
PDLIM1 PDZ and LIM domain 1 -0.508844
HSPB1 heat shock 27kDa protein 1 -0.446656
PGK1 phosphoglycerate kinase 1 -0.43341
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.416281
CXCL14 chemokine (C-X-C motif) ligand 14 -0.403454
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.403199
CRABP2 cellular retinoic acid binding protein 2 -0.397497
CLU clusterin -0.387498
DUSP12 dual specificity phosphatase 12 -0.367318
CYTL1 cytokine-like 1 -0.337066
MAB21L4 mab-21 like 4 -0.332188
ADGRG1 adhesion G protein-coupled receptor G1 -0.332188
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.331856
CALB2 calbindin 2 -0.326906
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -0.324423
GLS2 glutaminase 2 (liver, mitochondrial) -0.322758
ADGRL1 adhesion G protein-coupled receptor L1 -0.317413
CNN1 calponin 1, basic, smooth muscle -0.307786
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -0.30152
MMP24 matrix metallopeptidase 24 (membrane-inserted) -0.299359
KRT80 keratin 80, type II -0.281302
EDN2 endothelin 2 -0.274532
S100A2 S100 calcium binding protein A2 -0.274532
TIMP3 TIMP metallopeptidase inhibitor 3 -0.270696
PFDN1 prefoldin subunit 1 -0.266214
ACAA2 acetyl-CoA acyltransferase 2 -0.254926
RAB11FIP4 RAB11 family interacting protein 4 (class II) -0.252118
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.252118
LRRC37B leucine rich repeat containing 37B -0.232114
WNT11 wingless-type MMTV integration site family, member 11 -0.231046
TUT4 terminal uridylyl transferase 4 -0.228738
MED10 mediator complex subunit 10 -0.228578
RIPK2 receptor-interacting serine-threonine kinase 2 -0.218627
FAM47E-STBD1 FAM47E-STBD1 readthrough -0.209707