DA-49-ZD74_0.1uM Gene Set
Genes
41 genes differentially expressed following the DA-49-ZD74_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
BUD31
|
BUD31 homolog (S. cerevisiae)
|
2.65348
|
|
RPS5
|
ribosomal protein S5
|
0.874334
|
|
FAU
|
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
|
0.601943
|
|
FBXW5
|
F-box and WD repeat domain containing 5
|
0.562153
|
|
MYL2
|
myosin, light chain 2, regulatory, cardiac, slow
|
0.500706
|
|
RPL37A
|
ribosomal protein L37a
|
0.477023
|
|
MYL6
|
myosin, light chain 6, alkali, smooth muscle and non-muscle
|
0.390999
|
|
RPS15
|
ribosomal protein S15
|
0.379069
|
|
LGALS1
|
lectin, galactoside-binding, soluble, 1
|
0.352645
|
|
MANBAL
|
mannosidase, beta A, lysosomal-like
|
0.345479
|
|
RPS7
|
ribosomal protein S7
|
0.316361
|
|
NEDD8
|
neural precursor cell expressed, developmentally down-regulated 8
|
0.298727
|
|
GAPDH
|
glyceraldehyde-3-phosphate dehydrogenase
|
0.256527
|
|
AP2S1
|
adaptor-related protein complex 2, sigma 1 subunit
|
0.24373
|
|
TUBB
|
tubulin, beta class I
|
0.231525
|
|
UQCC3
|
ubiquinol-cytochrome c reductase complex assembly factor 3
|
0.226502
|
|
PSMB3
|
proteasome (prosome, macropain) subunit, beta type, 3
|
0.220791
|
|
RPLP2
|
ribosomal protein, large, P2
|
0.216519
|
|
TAGLN
|
transgelin
|
0.202795
|
|
NME1
|
NME/NM23 nucleoside diphosphate kinase 1
|
0.201072
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
PLEKHA8
|
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
|
-0.326406
|
|
ACTG1
|
actin gamma 1
|
-0.323467
|
|
YBX1
|
Y box binding protein 1
|
-0.313715
|
|
KLHL7
|
kelch-like family member 7
|
-0.313715
|
|
PAPOLA
|
poly(A) polymerase alpha
|
-0.307177
|
|
TSC22D1
|
TSC22 domain family, member 1
|
-0.302835
|
|
AHCY
|
adenosylhomocysteinase
|
-0.292323
|
|
EDARADD
|
EDAR-associated death domain
|
-0.266747
|
|
KIF20B
|
kinesin family member 20B
|
-0.253955
|
|
DHRS2
|
dehydrogenase/reductase (SDR family) member 2
|
-0.232437
|
|
PEF1
|
penta-EF-hand domain containing 1
|
-0.232437
|
|
VPS29
|
vacuolar protein sorting 29 homolog (S. cerevisiae)
|
-0.220791
|
|
DCBLD1
|
discoidin, CUB and LCCL domain containing 1
|
-0.213501
|
|
U2AF2
|
U2 small nuclear RNA auxiliary factor 2
|
-0.208561
|
|
GLTP
|
glycolipid transfer protein
|
-0.203892
|
|
STMN1
|
stathmin 1
|
-0.203892
|
|
TAB1
|
TGF-beta activated kinase 1/MAP3K7 binding protein 1
|
-0.202795
|
|
ID1
|
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
|
-0.202795
|
|
LYPD6
|
LY6/PLAUR domain containing 6
|
-0.202795
|
|
RUFY1
|
RUN and FYVE domain containing 1
|
-0.202795
|
|
PRMT5
|
protein arginine methyltransferase 5
|
-0.201604
|
