DA-49-ZD74_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, Latanoprost, Prostaglandin F agonists targeting PTGFR (Novartis, 5311221)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5311221
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Genes

45 genes differentially expressed following the DA-49-ZD74_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
BUD31 BUD31 homolog (S. cerevisiae) 1.19819
RPL37A ribosomal protein L37a 0.898593
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.680818
RPS5 ribosomal protein S5 0.67291
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.64878
RPLP2 ribosomal protein, large, P2 0.523719
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.523719
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.464001
RPL31 ribosomal protein L31 0.413441
C19ORF33 chromosome 19 open reading frame 33 0.402788
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.370224
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.368108
RPL28 ribosomal protein L28 0.368108
RPS7 ribosomal protein S7 0.368108
GNA12 guanine nucleotide binding protein (G protein) alpha 12 0.364441
ROMO1 reactive oxygen species modulator 1 0.353562
RPS15 ribosomal protein S15 0.339027
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.339027
FBXW5 F-box and WD repeat domain containing 5 0.303028
RPS24 ribosomal protein S24 0.289874
TUBB tubulin, beta class I 0.289874
RPL18A ribosomal protein L18a 0.288691
S100A2 S100 calcium binding protein A2 0.27319
S100A6 S100 calcium binding protein A6 0.220332
TMEM114 transmembrane protein 114 0.220013
ATOX1 antioxidant 1 copper chaperone 0.217237
IFI27L2 interferon, alpha-inducible protein 27-like 2 0.217237
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.209279
TMSB10 thymosin beta 10 0.207271
ATP5MG ATP synthase membrane subunit g 0.206028
COX7C cytochrome c oxidase subunit VIIc 0.201468
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.201198

decreased expression

Symbol Name Standardized Value
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 -0.392578
SHKBP1 SH3KBP1 binding protein 1 -0.370224
PKM pyruvate kinase, muscle -0.302111
BET1 Bet1 golgi vesicular membrane trafficking protein -0.289874
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.280907
PDAP1 PDGFA associated protein 1 -0.253516
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -0.250226
GDE1 glycerophosphodiester phosphodiesterase 1 -0.225585
DCTN5 dynactin 5 (p25) -0.224732
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit -0.221326
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -0.217237
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.213198
ZSCAN29 zinc finger and SCAN domain containing 29 -0.201198