DA-59-ZD74_0.01uM Gene Set
Genes
43 genes differentially expressed following the DA-59-ZD74_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
CST3
|
cystatin C
|
0.873313
|
|
PPDPF
|
pancreatic progenitor cell differentiation and proliferation factor
|
0.865028
|
|
TGFB1I1
|
transforming growth factor beta 1 induced transcript 1
|
0.557546
|
|
TIMM8B
|
translocase of inner mitochondrial membrane 8 homolog B (yeast)
|
0.493457
|
|
TPM2
|
tropomyosin 2 (beta)
|
0.477116
|
|
EIF5AL1
|
eukaryotic translation initiation factor 5A-like 1
|
0.453196
|
|
GPS2
|
G protein pathway suppressor 2
|
0.391712
|
|
RPS18
|
ribosomal protein S18
|
0.391712
|
|
RPL41
|
ribosomal protein L41
|
0.387118
|
|
HSPB1
|
heat shock 27kDa protein 1
|
0.386246
|
|
SRP14
|
signal recognition particle 14kDa (homologous Alu RNA binding protein)
|
0.350386
|
|
RPS11
|
ribosomal protein S11
|
0.345059
|
|
LMNA
|
lamin A/C
|
0.333649
|
|
RPS15
|
ribosomal protein S15
|
0.301977
|
|
MFGE8
|
milk fat globule-EGF factor 8 protein
|
0.262546
|
|
RPL37A
|
ribosomal protein L37a
|
0.260783
|
|
RPS5
|
ribosomal protein S5
|
0.247521
|
|
MYL2
|
myosin, light chain 2, regulatory, cardiac, slow
|
0.235193
|
|
PSMC3
|
proteasome (prosome, macropain) 26S subunit, ATPase, 3
|
0.233066
|
|
MYDGF
|
myeloid-derived growth factor
|
0.229804
|
|
NUDC
|
nudC nuclear distribution protein
|
0.218304
|
|
RPL27A
|
ribosomal protein L27a
|
0.215677
|
|
CUEDC2
|
CUE domain containing 2
|
0.214477
|
|
POLR2F
|
polymerase (RNA) II (DNA directed) polypeptide F
|
0.206614
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
SPC25
|
SPC25, NDC80 kinetochore complex component
|
-0.386719
|
|
SLC35F5
|
solute carrier family 35, member F5
|
-0.386246
|
|
SRP72
|
signal recognition particle 72kDa
|
-0.371255
|
|
ENAH
|
enabled homolog (Drosophila)
|
-0.349594
|
|
RAN
|
RAN, member RAS oncogene family
|
-0.325646
|
|
TRA2B
|
transformer 2 beta homolog (Drosophila)
|
-0.314438
|
|
RGS10
|
regulator of G-protein signaling 10
|
-0.249385
|
|
C11ORF58
|
chromosome 11 open reading frame 58
|
-0.243397
|
|
RPS8
|
ribosomal protein S8
|
-0.239448
|
|
BZW1
|
basic leucine zipper and W2 domains 1
|
-0.232971
|
|
EIF2A
|
eukaryotic translation initiation factor 2A, 65kDa
|
-0.230246
|
|
CENPW
|
centromere protein W
|
-0.214087
|
|
PEBP1
|
phosphatidylethanolamine binding protein 1
|
-0.211555
|
|
SARDH
|
sarcosine dehydrogenase
|
-0.211555
|
|
TMEM106B
|
transmembrane protein 106B
|
-0.211555
|
|
EIF3F
|
eukaryotic translation initiation factor 3, subunit F
|
-0.211555
|
|
SRSF3
|
serine/arginine-rich splicing factor 3
|
-0.208531
|
|
EID1
|
EP300 interacting inhibitor of differentiation 1
|
-0.206614
|
|
MRFAP1
|
Morf4 family associated protein 1
|
-0.204789
|
