DA-59-ZD74_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, Bosentan, Endothelin ETB Receptor Antagonists;Endothelin ETA Receptor Antagonists targeting EDNRA, EDNRB (Novartis, 104865)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/104865
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Genes

277 genes differentially expressed following the DA-59-ZD74_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 2.08585
TGFB1I1 transforming growth factor beta 1 induced transcript 1 1.74481
UBC ubiquitin C 1.40638
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 1.32755
RPS15 ribosomal protein S15 1.2421
KRT18 keratin 18, type I 1.17605
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.17605
SNU13 small nuclear ribonucleoprotein 13 1.12043
LMNA lamin A/C 0.991902
STOML2 stomatin (EPB72)-like 2 0.959603
HSPB1 heat shock 27kDa protein 1 0.890835
TAGLN transgelin 0.879821
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.87971
ATOX1 antioxidant 1 copper chaperone 0.878874
ZNF90 zinc finger protein 90 0.878874
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.793655
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.769351
RPS7 ribosomal protein S7 0.760046
RPS5 ribosomal protein S5 0.760046
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.750428
CST3 cystatin C 0.73338
SNRPA small nuclear ribonucleoprotein polypeptide A 0.698645
TPM2 tropomyosin 2 (beta) 0.670439
GNG5 guanine nucleotide binding protein (G protein), gamma 5 0.636535
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) 0.627249
RPL37A ribosomal protein L37a 0.625143
RPL31 ribosomal protein L31 0.610156
PLEC plectin 0.598768
RPL15 ribosomal protein L15 0.596901
ROMO1 reactive oxygen species modulator 1 0.596579
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.577909
MLF2 myeloid leukemia factor 2 0.561114
VPS35L VPS35 endosomal protein sorting factor like 0.547976
TIMP1 TIMP metallopeptidase inhibitor 1 0.535421
PTOV1 prostate tumor overexpressed 1 0.510786
GSTP1 glutathione S-transferase pi 1 0.504048
KEAP1 kelch-like ECH-associated protein 1 0.493486
CSNK2B casein kinase 2, beta polypeptide 0.481967
THOC6 THO complex 6 0.479863
KRT17 keratin 17, type I 0.464608
PCOLCE procollagen C-endopeptidase enhancer 0.45586
TBCB tubulin folding cofactor B 0.454857
MVP major vault protein 0.436239
TNNI3 troponin I type 3 (cardiac) 0.435656
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 0.433157
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.423916
LGALS1 lectin, galactoside-binding, soluble, 1 0.418796
DDTL D-dopachrome tautomerase-like 0.416171
CD59 CD59 molecule, complement regulatory protein 0.413365
RPLP2 ribosomal protein, large, P2 0.401702
P4HB prolyl 4-hydroxylase, beta polypeptide 0.399254
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.398016
PGRMC2 progesterone receptor membrane component 2 0.398008
RPL27A ribosomal protein L27a 0.396983
PRAF2 PRA1 domain family, member 2 0.394952
DDIT4 DNA-damage-inducible transcript 4 0.386785
RPL18A ribosomal protein L18a 0.383371
SEC14L5 SEC14-like 5 (S. cerevisiae) 0.373982
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.356974
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.345073
CD151 CD151 molecule (Raph blood group) 0.340315
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.335691
DMKN dermokine 0.330911
MICALL1 MICAL-like 1 0.323115
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.311801
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.309638
RPL41 ribosomal protein L41 0.30934
CADM4 cell adhesion molecule 4 0.300274
PLRG1 pleiotropic regulator 1 0.299891
PES1 pescadillo ribosomal biogenesis factor 1 0.295667
RPS27 ribosomal protein S27 0.295667
MICALL2 MICAL-like 2 0.292126
UCK2 uridine-cytidine kinase 2 0.289088
TNNT1 troponin T type 1 (skeletal, slow) 0.28806
EIF4E2 eukaryotic translation initiation factor 4E family member 2 0.285686
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 0.271968
CDC20 cell division cycle 20 0.269576
ZNRD2 zinc ribbon domain containing 2 0.26949
HMGA1 high mobility group AT-hook 1 0.26949
TERT telomerase reverse transcriptase 0.268364
BCAR1 breast cancer anti-estrogen resistance 1 0.26584
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.265161
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.264283
GPC1 glypican 1 0.264135
FUOM fucose mutarotase 0.262944
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.259194
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.25627
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.25627
APEH acylaminoacyl-peptide hydrolase 0.25364
AXL AXL receptor tyrosine kinase 0.252328
HDGF hepatoma-derived growth factor 0.248696
SHISA5 shisa family member 5 0.248424
MFGE8 milk fat globule-EGF factor 8 protein 0.246804
PEX14 peroxisomal biogenesis factor 14 0.246481
JUND jun D proto-oncogene 0.244905
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.244548
SNX8 sorting nexin 8 0.242937
TAGLN2 transgelin 2 0.237649
TMEM9 transmembrane protein 9 0.237206
DHPS deoxyhypusine synthase 0.236531
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.236157
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 0.235558
CRYAB crystallin, alpha B 0.235224
PRMT1 protein arginine methyltransferase 1 0.233996
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.230008
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.228902
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.227659
BLVRB biliverdin reductase B 0.226815
CCDC12 coiled-coil domain containing 12 0.226815
RNF114 ring finger protein 114 0.222086
DOK7 docking protein 7 0.219636
KRT81 keratin 81, type II 0.217814
RHOG ras homolog family member G 0.214653
ATP5ME ATP synthase membrane subunit e 0.212221
PGP phosphoglycolate phosphatase 0.211801
WASHC4 WASH complex subunit 4 0.210015
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.208909
OLFML3 olfactomedin-like 3 0.207408
RUNX1 runt-related transcription factor 1 0.207037
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.205539
PDGFC platelet derived growth factor C 0.202758
JOSD1 Josephin domain containing 1 0.20151
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.20151

decreased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -1.17402
ACTG1 actin gamma 1 -0.926905
DPH7 diphthamide biosynthesis 7 -0.887173
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -0.837674
STMN1 stathmin 1 -0.761672
YBX1 Y box binding protein 1 -0.7135
SDF2L1 stromal cell-derived factor 2-like 1 -0.695859
FSTL1 follistatin-like 1 -0.674774
SERF2 small EDRK-rich factor 2 -0.637074
JTB jumping translocation breakpoint -0.616704
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -0.610306
CCDC167 coiled-coil domain containing 167 -0.602344
TGIF1 TGFB-induced factor homeobox 1 -0.596901
SPPL2A signal peptide peptidase like 2A -0.592243
RPS28 ribosomal protein S28 -0.585682
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.583249
POTEF POTE ankyrin domain family, member F -0.582813
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.550011
MIEN1 migration and invasion enhancer 1 -0.547976
WHR1 winged helix repair factor 1 -0.541112
RPS8 ribosomal protein S8 -0.519094
PKM pyruvate kinase, muscle -0.516621
MRGBP MRG/MORF4L binding protein -0.516621
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.509957
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.50502
EIF3B eukaryotic translation initiation factor 3, subunit B -0.501131
PEX2 peroxisomal biogenesis factor 2 -0.464608
ENO1 enolase 1, (alpha) -0.458697
PKP4 plakophilin 4 -0.452867
XPO5 exportin 5 -0.44006
RPL29 ribosomal protein L29 -0.43536
CLPTM1L CLPTM1-like -0.43211
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -0.428502
SUMO2 small ubiquitin-like modifier 2 -0.42492
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.418801
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.416171
PCLAF PCNA clamp associated factor -0.409382
SCPEP1 serine carboxypeptidase 1 -0.405037
RPL10A ribosomal protein L10a -0.397948
TSEN34 TSEN34 tRNA splicing endonuclease subunit -0.391502
EIF1 eukaryotic translation initiation factor 1 -0.381579
USP1 ubiquitin specific peptidase 1 -0.377157
C1ORF122 chromosome 1 open reading frame 122 -0.377157
IGFBP7 insulin-like growth factor binding protein 7 -0.375561
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.371629
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -0.359012
NAT10 N-acetyltransferase 10 (GCN5-related) -0.355924
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.355924
CDK4 cyclin-dependent kinase 4 -0.355924
GCN1 GCN1 activator of EIF2AK4 -0.355262
MRFAP1 Morf4 family associated protein 1 -0.352424
MRPL13 mitochondrial ribosomal protein L13 -0.352284
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase -0.351572
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.34959
GOLGB1 golgin B1 -0.346949
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.346474
KMT2E lysine (K)-specific methyltransferase 2E -0.342425
NCBP2AS2 NCBP2 antisense 2 (head to head) -0.337881
FTH1 ferritin, heavy polypeptide 1 -0.335403
RPL34 ribosomal protein L34 -0.335147
TMED9 transmembrane emp24 protein transport domain containing 9 -0.334511
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -0.32823
MTCH1 mitochondrial carrier 1 -0.323115
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.318203
RBM19 RNA binding motif protein 19 -0.318203
SNX12 sorting nexin 12 -0.31653
SIVA1 SIVA1, apoptosis-inducing factor -0.307895
RPS17 ribosomal protein S17 -0.305941
TMED3 transmembrane emp24 protein transport domain containing 3 -0.299215
PRDX1 peroxiredoxin 1 -0.297368
NFIB nuclear factor I/B -0.295029
RPL6 ribosomal protein L6 -0.294273
TSPAN5 tetraspanin 5 -0.292906
ADI1 acireductone dioxygenase 1 -0.290307
SACK1D scaffolding CK1 anchoring protein D -0.287904
TPI1 triosephosphate isomerase 1 -0.286346
HDAC1 histone deacetylase 1 -0.281228
TPGS2 tubulin polyglutamylase complex subunit 2 -0.280536
TMEM98 transmembrane protein 98 -0.27972
SLC35B1 solute carrier family 35, member B1 -0.275184
MTFMT mitochondrial methionyl-tRNA formyltransferase -0.27516
LY6E lymphocyte antigen 6 complex, locus E -0.272348
S100A10 S100 calcium binding protein A10 -0.271968
AHCYL1 adenosylhomocysteinase-like 1 -0.271193
USP9X ubiquitin specific peptidase 9, X-linked -0.270081
COX14 COX14 cytochrome c oxidase assembly factor -0.269576
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.26949
RAB43 RAB43, member RAS oncogene family -0.265161
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.264135
TOMM34 translocase of outer mitochondrial membrane 34 -0.263459
UXT ubiquitously-expressed, prefoldin-like chaperone -0.263459
RPL9 ribosomal protein L9 -0.260155
TPT1 tumor protein, translationally-controlled 1 -0.25883
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -0.256337
DNAAF5 dynein, axonemal, assembly factor 5 -0.25627
ERH enhancer of rudimentary homolog (Drosophila) -0.255538
DUSP7 dual specificity phosphatase 7 -0.253741
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.251249
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -0.247498
TPM1 tropomyosin 1 (alpha) -0.244077
MOXD1 monooxygenase, DBH-like 1 -0.244063
FAF1 Fas (TNFRSF6) associated factor 1 -0.243251
TARDBP TAR DNA binding protein -0.242412
IL17RA interleukin 17 receptor A -0.241582
OIP5 Opa interacting protein 5 -0.241191
NUP62 nucleoporin 62kDa -0.24103
BHLHE40 basic helix-loop-helix family, member e40 -0.236924
C1ORF43 chromosome 1 open reading frame 43 -0.235017
PMF1-BGLAP PMF1-BGLAP readthrough -0.233144
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) -0.231653
ZNF71 zinc finger protein 71 -0.230748
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 -0.230149
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.229851
SSRP1 structure specific recognition protein 1 -0.229569
PTMA prothymosin, alpha -0.229431
CHMP2B charged multivesicular body protein 2B -0.229026
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.228521
KCTD10 potassium channel tetramerization domain containing 10 -0.228265
ACAD9 acyl-CoA dehydrogenase family, member 9 -0.223795
ACTN1 actinin, alpha 1 -0.223263
PDLIM7 PDZ and LIM domain 7 (enigma) -0.222585
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -0.222086
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.221437
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.219953
SNRPC small nuclear ribonucleoprotein polypeptide C -0.219953
MRPS2 mitochondrial ribosomal protein S2 -0.219636
PGK1 phosphoglycerate kinase 1 -0.219566
RACGAP1 Rac GTPase activating protein 1 -0.218447
LAPTM4B lysosomal protein transmembrane 4 beta -0.218447
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.216435
HLA-B major histocompatibility complex, class I, B -0.215818
DYNLL1 dynein, light chain, LC8-type 1 -0.215602
THRAP3 thyroid hormone receptor associated protein 3 -0.215481
STIP1 stress-induced phosphoprotein 1 -0.214653
IGBP1 immunoglobulin (CD79A) binding protein 1 -0.213895
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.212702
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.211833
GPX4 glutathione peroxidase 4 -0.211833
MPLKIP M-phase specific PLK1 interacting protein -0.211192
DDHD2 DDHD domain containing 2 -0.210291
URI1 URI1, prefoldin-like chaperone -0.210163
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.208604
GLRX glutaredoxin (thioltransferase) -0.207423
PRDX5 peroxiredoxin 5 -0.207423
AHCY adenosylhomocysteinase -0.207423
CCDC142 coiled-coil domain containing 142 -0.202611
FHL2 four and a half LIM domains 2 -0.201942
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha -0.201544
RPL8 ribosomal protein L8 -0.20151
CELF1 CUGBP, Elav-like family member 1 -0.200767
RHOT1 ras homolog family member T1 -0.200767
MED14 mediator complex subunit 14 -0.200767
UBE3A ubiquitin protein ligase E3A -0.200767
COA3 cytochrome c oxidase assembly factor 3 -0.200767