| Dataset | NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles |
| Category | transcriptomics |
| Type | drug perturbation |
| Description | Dose=10uM, Bosentan, Endothelin ETB Receptor Antagonists;Endothelin ETA Receptor Antagonists targeting EDNRA, EDNRB (Novartis, 104865) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/104865 |
| Similar Terms | |
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130 genes differentially expressed following the DA-59-ZD74_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| UBC | ubiquitin C | 1.38454 |
| CDC20 | cell division cycle 20 | 1.17658 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.953827 |
| RPS16 | ribosomal protein S16 | 0.916849 |
| GNG5 | guanine nucleotide binding protein (G protein), gamma 5 | 0.888363 |
| SNU13 | small nuclear ribonucleoprotein 13 | 0.785752 |
| RPS15 | ribosomal protein S15 | 0.756711 |
| LMNA | lamin A/C | 0.727845 |
| PLEC | plectin | 0.727845 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 0.618026 |
| RRP9 | ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) | 0.582761 |
| TMEM258 | transmembrane protein 258 | 0.569435 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.568641 |
| GSTP1 | glutathione S-transferase pi 1 | 0.566429 |
| ROMO1 | reactive oxygen species modulator 1 | 0.564993 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | 0.535225 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.504228 |
| THOC6 | THO complex 6 | 0.498018 |
| NDUFA11 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa | 0.47521 |
| RPL31 | ribosomal protein L31 | 0.453288 |
| RPL37A | ribosomal protein L37a | 0.418946 |
| CSNK2B | casein kinase 2, beta polypeptide | 0.41303 |
| RPS7 | ribosomal protein S7 | 0.409701 |
| S100A6 | S100 calcium binding protein A6 | 0.389361 |
| SCO2 | SCO2 cytochrome c oxidase assembly protein | 0.387258 |
| HSPB1 | heat shock 27kDa protein 1 | 0.37673 |
| CST3 | cystatin C | 0.367759 |
| JUND | jun D proto-oncogene | 0.346772 |
| KRT17 | keratin 17, type I | 0.336564 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.319883 |
| TPM2 | tropomyosin 2 (beta) | 0.313039 |
| TAGLN | transgelin | 0.302179 |
| MICALL1 | MICAL-like 1 | 0.302179 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.297776 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.286145 |
| PTOV1 | prostate tumor overexpressed 1 | 0.286145 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.283689 |
| TIMM44 | translocase of inner mitochondrial membrane 44 homolog (yeast) | 0.274456 |
| ATOX1 | antioxidant 1 copper chaperone | 0.270461 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.267527 |
| NDUFB10 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa | 0.262222 |
| APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | 0.256531 |
| KRT18 | keratin 18, type I | 0.256531 |
| JOSD1 | Josephin domain containing 1 | 0.254011 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | 0.252659 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.252643 |
| ZNRD2 | zinc ribbon domain containing 2 | 0.252643 |
| SNRPD2 | small nuclear ribonucleoprotein D2 polypeptide 16.5kDa | 0.252607 |
| RPS5 | ribosomal protein S5 | 0.251843 |
| MLF2 | myeloid leukemia factor 2 | 0.251843 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.250619 |
| LDLRAP1 | low density lipoprotein receptor adaptor protein 1 | 0.249151 |
| PCSK7 | proprotein convertase subtilisin/kexin type 7 | 0.240978 |
| EIF3G | eukaryotic translation initiation factor 3, subunit G | 0.240978 |
| RPL28 | ribosomal protein L28 | 0.236585 |
| RPN1 | ribophorin I | 0.23632 |
| SHISA5 | shisa family member 5 | 0.231658 |
| CMTM3 | CKLF-like MARVEL transmembrane domain containing 3 | 0.228987 |
| CD59 | CD59 molecule, complement regulatory protein | 0.22513 |
| RBM38 | RNA binding motif protein 38 | 0.223809 |
| C19ORF33 | chromosome 19 open reading frame 33 | 0.220512 |
| RPL27A | ribosomal protein L27a | 0.21727 |
| RPS18 | ribosomal protein S18 | 0.21604 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.214381 |
| A2M | alpha-2-macroglobulin | 0.204529 |
| STOML2 | stomatin (EPB72)-like 2 | 0.201919 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL9 | ribosomal protein L9 | -0.758024 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.573289 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.497369 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.492272 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.492048 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.478003 |
| LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 | -0.47521 |
| RPL34 | ribosomal protein L34 | -0.453288 |
| RPS4X | ribosomal protein S4, X-linked | -0.432457 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -0.420952 |
| RPS23 | ribosomal protein S23 | -0.398796 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.389815 |
| RPS8 | ribosomal protein S8 | -0.387782 |
| UNG | uracil-DNA glycosylase | -0.375157 |
| RPL10A | ribosomal protein L10a | -0.374585 |
| SERF2 | small EDRK-rich factor 2 | -0.372473 |
| RPL23A | ribosomal protein L23a | -0.372473 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -0.360741 |
| DNASE1L1 | deoxyribonuclease I-like 1 | -0.33735 |
| RBMXL1 | RNA binding motif protein, X-linked-like 1 | -0.313139 |
| SPPL2A | signal peptide peptidase like 2A | -0.313139 |
| ERH | enhancer of rudimentary homolog (Drosophila) | -0.308789 |
| SF1 | splicing factor 1 | -0.297996 |
| ISCA1 | iron-sulfur cluster assembly 1 | -0.297967 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.297776 |
| SFTPA2 | surfactant protein A2 | -0.296929 |
| ELMO2 | engulfment and cell motility 2 | -0.295385 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.295385 |
| NME1-NME2 | NME1-NME2 readthrough | -0.291195 |
| POTEF | POTE ankyrin domain family, member F | -0.290489 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.287224 |
| STMN1 | stathmin 1 | -0.278743 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.278438 |
| CFL2 | cofilin 2 (muscle) | -0.278209 |
| IFT52 | intraflagellar transport 52 | -0.278209 |
| SARAF | store-operated calcium entry-associated regulatory factor | -0.275494 |
| GGA3 | golgi-associated, gamma adaptin ear containing, ARF binding protein 3 | -0.257207 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.257207 |
| EIF3K | eukaryotic translation initiation factor 3, subunit K | -0.256298 |
| RPLP1 | ribosomal protein, large, P1 | -0.256175 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -0.252607 |
| REEP5 | receptor accessory protein 5 | -0.252044 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | -0.246472 |
| RPS17 | ribosomal protein S17 | -0.243479 |
| ADI1 | acireductone dioxygenase 1 | -0.242448 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.235961 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.234437 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.233833 |
| PTMA | prothymosin, alpha | -0.233833 |
| NLRP2B | NLR family pyrin domain containing 2B | -0.231276 |
| TMEM106C | transmembrane protein 106C | -0.230358 |
| ALG2 | ALG2, alpha-1,3/1,6-mannosyltransferase | -0.228987 |
| XPC | xeroderma pigmentosum, complementation group C | -0.226852 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | -0.223847 |
| SSRP1 | structure specific recognition protein 1 | -0.223809 |
| TRMT5 | tRNA methyltransferase 5 | -0.222768 |
| RPS27A | ribosomal protein S27a | -0.21727 |
| TSR3 | TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) | -0.21727 |
| RNF11 | ring finger protein 11 | -0.211481 |
| CCN2 | cellular communication network factor 2 | -0.207469 |
| NDUFB2 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa | -0.205557 |
| KLHL18 | kelch-like family member 18 | -0.205142 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -0.204048 |
| YBX1 | Y box binding protein 1 | -0.203239 |
