DA-59-ZD74_1uM Gene Set

Dataset	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category	transcriptomics
Type	drug perturbation
Description	Dose=1uM, Bosentan, Endothelin ETB Receptor Antagonists;Endothelin ETA Receptor Antagonists targeting EDNRA, EDNRB (Novartis, 104865)
External Link	https://pubchem.ncbi.nlm.nih.gov/compound/104865
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Genes

14 genes differentially expressed following the DA-59-ZD74_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol	Name	Standardized Value
TAGLN	transgelin	0.72084
NBEAL1	neurobeachin-like 1	0.335903
MYEOV	myeloma overexpressed	0.314485
RPL12	ribosomal protein L12	0.310272
TPM1	tropomyosin 1 (alpha)	0.302343
GMPR	guanosine monophosphate reductase	0.228471
FRG2C	FSHD region gene 2 family, member C	0.208643

decreased expression

Symbol	Name	Standardized Value
DHRS2	dehydrogenase/reductase (SDR family) member 2	-1.54722
MT2A	metallothionein 2A	-0.967116
CPA4	carboxypeptidase A4	-0.37405
KAT7	K(lysine) acetyltransferase 7	-0.37405
ACP2	acid phosphatase 2, lysosomal	-0.300556
GSN	gelsolin	-0.208643
FTL	ferritin, light polypeptide	-0.200101