DA-75-KD59_0.01uM Gene Set
| Dataset |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
|
| Category |
transcriptomics
|
| Type |
drug perturbation |
| Description |
Dose=0.01uM, (2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-3-(hydroxymethyl)-2-p-tolylsuccinamide, MMP-13 (Collagenase 3) Inhibitors;MMP-9 (Gelatinase B) Inhibitors;MMP-1 (Interstitial Collagenase) Inhibitors;ADAM17 (TNF-alpha-Converting Enzyme (TACE) Inhibitors);MMP-2 (Gelatinase A) Inhibitors targeting MMP1, MMP2, MMP9, MMP13, ADAM17 (Novartis, 9907830)
|
| External Link |
https://pubchem.ncbi.nlm.nih.gov/compound/9907830
|
| Similar Terms |
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| Downloads & Tools |
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Genes
16 genes differentially expressed following the DA-75-KD59_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
RPS11
|
ribosomal protein S11
|
0.269604
|
|
PPDPF
|
pancreatic progenitor cell differentiation and proliferation factor
|
0.232136
|
|
PGP
|
phosphoglycolate phosphatase
|
0.203983
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
APBB2
|
amyloid beta (A4) precursor protein-binding, family B, member 2
|
-0.395616
|
|
CHURC1
|
churchill domain containing 1
|
-0.395616
|
|
PMEPA1
|
prostate transmembrane protein, androgen induced 1
|
-0.311849
|
|
ABCD3
|
ATP-binding cassette, sub-family D (ALD), member 3
|
-0.288995
|
|
DHRS2
|
dehydrogenase/reductase (SDR family) member 2
|
-0.288995
|
|
STARD4
|
StAR-related lipid transfer (START) domain containing 4
|
-0.232136
|
|
AUNIP
|
aurora kinase A and ninein interacting protein
|
-0.228173
|
|
SARDH
|
sarcosine dehydrogenase
|
-0.207536
|
|
PLS3
|
plastin 3
|
-0.207536
|
|
BLOC1S4
|
biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
|
-0.203983
|
|
XPNPEP1
|
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
|
-0.203983
|
|
NDFIP2
|
Nedd4 family interacting protein 2
|
-0.203983
|
|
PILRA
|
paired immunoglobin-like type 2 receptor alpha
|
-0.203983
|
