DA-75-KD59_0.1uM Gene Set
| Dataset |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
|
| Category |
transcriptomics
|
| Type |
drug perturbation |
| Description |
Dose=0.1uM, (2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-3-(hydroxymethyl)-2-p-tolylsuccinamide, MMP-13 (Collagenase 3) Inhibitors;MMP-9 (Gelatinase B) Inhibitors;MMP-1 (Interstitial Collagenase) Inhibitors;ADAM17 (TNF-alpha-Converting Enzyme (TACE) Inhibitors);MMP-2 (Gelatinase A) Inhibitors targeting MMP1, MMP2, MMP9, MMP13, ADAM17 (Novartis, 9907830)
|
| External Link |
https://pubchem.ncbi.nlm.nih.gov/compound/9907830
|
| Similar Terms |
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| Downloads & Tools |
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Genes
14 genes differentially expressed following the DA-75-KD59_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
OXA1L
|
oxidase (cytochrome c) assembly 1-like
|
0.870761
|
|
MYL2
|
myosin, light chain 2, regulatory, cardiac, slow
|
0.532624
|
|
PPDPF
|
pancreatic progenitor cell differentiation and proliferation factor
|
0.456116
|
|
PGP
|
phosphoglycolate phosphatase
|
0.436442
|
|
GNG5
|
guanine nucleotide binding protein (G protein), gamma 5
|
0.32273
|
|
CD59
|
CD59 molecule, complement regulatory protein
|
0.288044
|
|
DAD1
|
defender against cell death 1
|
0.228433
|
|
UQCRC1
|
ubiquinol-cytochrome c reductase core protein I
|
0.207901
|
|
ST3GAL3
|
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
|
0.203194
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
SNN
|
stannin
|
-0.347161
|
|
PDLIM3
|
PDZ and LIM domain 3
|
-0.286023
|
|
EPS15
|
epidermal growth factor receptor pathway substrate 15
|
-0.262375
|
|
SLC25A44
|
solute carrier family 25, member 44
|
-0.233493
|
|
LARP4
|
La ribonucleoprotein domain family, member 4
|
-0.223517
|
