DA-75-KD59_10uM Gene Set
| Dataset |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
|
| Category |
transcriptomics
|
| Type |
drug perturbation |
| Description |
Dose=10uM, (2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-3-(hydroxymethyl)-2-p-tolylsuccinamide, MMP-13 (Collagenase 3) Inhibitors;MMP-9 (Gelatinase B) Inhibitors;MMP-1 (Interstitial Collagenase) Inhibitors;ADAM17 (TNF-alpha-Converting Enzyme (TACE) Inhibitors);MMP-2 (Gelatinase A) Inhibitors targeting MMP1, MMP2, MMP9, MMP13, ADAM17 (Novartis, 9907830)
|
| External Link |
https://pubchem.ncbi.nlm.nih.gov/compound/9907830
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| Similar Terms |
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| Downloads & Tools |
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Genes
6 genes differentially expressed following the DA-75-KD59_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
EIF4EBP1
|
eukaryotic translation initiation factor 4E binding protein 1
|
0.340387
|
|
PPDPF
|
pancreatic progenitor cell differentiation and proliferation factor
|
0.232867
|
|
RPS11
|
ribosomal protein S11
|
0.217067
|
|
EEF1A1
|
eukaryotic translation elongation factor 1 alpha 1
|
0.206304
|
|
UQCRC1
|
ubiquinol-cytochrome c reductase core protein I
|
0.204391
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
ZNF789
|
zinc finger protein 789
|
-0.217067
|
