DA-75-KD59_1uM Gene Set
| Dataset |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
|
| Category |
transcriptomics
|
| Type |
drug perturbation |
| Description |
Dose=1uM, (2S,3R)-N1-((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-N4-hydroxy-3-(hydroxymethyl)-2-p-tolylsuccinamide, MMP-13 (Collagenase 3) Inhibitors;MMP-9 (Gelatinase B) Inhibitors;MMP-1 (Interstitial Collagenase) Inhibitors;ADAM17 (TNF-alpha-Converting Enzyme (TACE) Inhibitors);MMP-2 (Gelatinase A) Inhibitors targeting MMP1, MMP2, MMP9, MMP13, ADAM17 (Novartis, 9907830)
|
| External Link |
https://pubchem.ncbi.nlm.nih.gov/compound/9907830
|
| Similar Terms |
|
| Downloads & Tools |
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Genes
35 genes differentially expressed following the DA-75-KD59_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
BEST1
|
bestrophin 1
|
1.10586
|
|
FTL
|
ferritin, light polypeptide
|
1.01518
|
|
FTH1
|
ferritin, heavy polypeptide 1
|
1.01518
|
|
TRIM16
|
tripartite motif containing 16
|
1.01518
|
|
TXNRD1
|
thioredoxin reductase 1
|
0.788135
|
|
PGP
|
phosphoglycolate phosphatase
|
0.502127
|
|
CLPTM1L
|
CLPTM1-like
|
0.349303
|
|
SQSTM1
|
sequestosome 1
|
0.32128
|
|
NQO1
|
NAD(P)H dehydrogenase, quinone 1
|
0.2647
|
|
AKR1B1
|
aldo-keto reductase family 1, member B1 (aldose reductase)
|
0.2647
|
|
XAGE1A
|
X antigen family member 1A
|
0.255605
|
|
CLU
|
clusterin
|
0.232204
|
|
CRYAB
|
crystallin, alpha B
|
0.232204
|
|
AKR1C3
|
aldo-keto reductase family 1, member C3
|
0.223322
|
|
PRDX1
|
peroxiredoxin 1
|
0.223322
|
|
KIAA0319
|
KIAA0319
|
0.217071
|
|
MYL6
|
myosin, light chain 6, alkali, smooth muscle and non-muscle
|
0.204111
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
TGM2
|
transglutaminase 2
|
-2.06532
|
|
APOBEC3B
|
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
|
-1.13563
|
|
RAB34
|
RAB34, member RAS oncogene family
|
-0.843236
|
|
SREBF1
|
sterol regulatory element binding transcription factor 1
|
-0.841872
|
|
LOXL4
|
lysyl oxidase-like 4
|
-0.668998
|
|
KRT8
|
keratin 8, type II
|
-0.539552
|
|
ANXA11
|
annexin A11
|
-0.507121
|
|
CPA4
|
carboxypeptidase A4
|
-0.456154
|
|
KRTAP2-3
|
keratin associated protein 2-3
|
-0.436434
|
|
TINAGL1
|
tubulointerstitial nephritis antigen-like 1
|
-0.428707
|
|
KLK6
|
kallikrein-related peptidase 6
|
-0.415319
|
|
RNF187
|
ring finger protein 187
|
-0.372976
|
|
MDK
|
midkine (neurite growth-promoting factor 2)
|
-0.316432
|
|
UPP1
|
uridine phosphorylase 1
|
-0.25202
|
|
DNAJB1
|
DnaJ (Hsp40) homolog, subfamily B, member 1
|
-0.240489
|
|
ZXDB
|
zinc finger, X-linked, duplicated B
|
-0.240096
|
|
IFFO2
|
intermediate filament family orphan 2
|
-0.231216
|
|
PMEPA1
|
prostate transmembrane protein, androgen induced 1
|
-0.218653
|
