DA-79-ZD74_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, Acacetin, Melanin Inhibitors;Xanthine Oxidase Inhibitors targeting XDH (Novartis, 5280442)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5280442
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Genes

11 genes differentially expressed following the DA-79-ZD74_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RRM2 ribonucleotide reductase M2 2.09285
MT1X metallothionein 1X 0.919776
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.74366
ARF1 ADP-ribosylation factor 1 0.697428
RPS18 ribosomal protein S18 0.596619
S100A2 S100 calcium binding protein A2 0.575259
THOC6 THO complex 6 0.326763
STOML2 stomatin (EPB72)-like 2 0.297278
C6ORF58 chromosome 6 open reading frame 58 0.275938

decreased expression

Symbol Name Standardized Value
NME1-NME2 NME1-NME2 readthrough -0.267155
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.206222