DACH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description dachshund family transcription factor 1|This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 1602)
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Genes

341 genes differentially expressed following the DACH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MYBPHL myosin binding protein H-like 3.25179
OSR2 odd-skipped related transciption factor 2 3.25179
APLN apelin 3.25179
XCL1 chemokine (C motif) ligand 1 3.25179
NFAM1 NFAT activating protein with ITAM motif 1 3.25179
PBOV1 prostate and breast cancer overexpressed 1 3.25179
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.25179
TDRD6 tudor domain containing 6 3.25179
C9ORF152 chromosome 9 open reading frame 152 3.25179
OR51L1 olfactory receptor, family 51, subfamily L, member 1 3.25179
TM4SF20 transmembrane 4 L six family member 20 3.25179
HES4 hes family bHLH transcription factor 4 3.25179
HGD homogentisate 1,2-dioxygenase 3.25179
MYO7B myosin VIIB 3.25179
ZNF503 zinc finger protein 503 3.25179
SCGN secretagogin, EF-hand calcium binding protein 3.25179
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.25179
SCN2A sodium channel, voltage gated, type II alpha subunit 3.25179
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.25179
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.25179
TSGA13 testis specific, 13 3.25179
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.25179
UMODL1 uromodulin-like 1 3.25179
CD68 CD68 molecule 3.25179
ATG4A autophagy related 4A, cysteine peptidase 3.25179
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.25179
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.25179
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.25179
TMEM132C transmembrane protein 132C 3.25179
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.25179
LHX1 LIM homeobox 1 3.25179
GRM6 glutamate receptor, metabotropic 6 3.25179
ACADL acyl-CoA dehydrogenase, long chain 3.25179
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.25179
TSHZ1 teashirt zinc finger homeobox 1 3.25179
TAS2R13 taste receptor, type 2, member 13 3.25179
LACTBL1 lactamase, beta-like 1 3.25179
MEIKIN meiotic kinetochore factor 3.25179
COPZ2 coatomer protein complex, subunit zeta 2 3.25179
ADAT3 adenosine deaminase, tRNA-specific 3 3.25179
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.25179
MISP mitotic spindle positioning 3.25179
TREML2 triggering receptor expressed on myeloid cells-like 2 3.25179
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 3.25179
ATOH1 atonal homolog 1 (Drosophila) 3.25179
NLRP11 NLR family, pyrin domain containing 11 3.25179
HNF4A hepatocyte nuclear factor 4, alpha 3.25179
OR1R1 olfactory receptor family 1 subfamily R member 1 3.25179
PCDHGA9 protocadherin gamma subfamily A, 9 3.25179
UNC93A unc-93 homolog A (C. elegans) 3.25179
PROP1 PROP paired-like homeobox 1 3.25179
LTB4R2 leukotriene B4 receptor 2 3.25179
PNLIPRP1 pancreatic lipase-related protein 1 3.25179
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.25179
ACER1 alkaline ceramidase 1 3.25179
FMO1 flavin containing monooxygenase 1 3.25179
C9ORF43 chromosome 9 open reading frame 43 3.25179
ALDOB aldolase B, fructose-bisphosphate 3.25179
CRACDL CRACD like 3.25179
AJM1 apical junction component 1 homolog 3.25179
OR56B2 olfactory receptor family 56 subfamily B member 2 3.25179
EXOC1L exocyst complex component 1 like 3.25179
WASH8P WAS protein family homolog 8, pseudogene 3.25179
MCTS2 MCTS family member 2 3.25179
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.25179
PEAK3 PEAK family member 3 3.25179
CFAP276 cilia and flagella associated protein 276 3.25179
CHCT1 CHD1 helical C-terminal domain containing 1 3.25179
CFAP100 cilia and flagella associated protein 100 3.25179
MYZAP myocardial zonula adherens protein 3.25179
C1QTNF9B C1q and tumor necrosis factor related protein 9B 3.25179
INSRR insulin receptor-related receptor 3.25179
RNF113B ring finger protein 113B 3.25179
MIA melanoma inhibitory activity 3.25179
TLR4 toll-like receptor 4 3.25179
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.25179
ULBP1 UL16 binding protein 1 3.25179
OLAH oleoyl-ACP hydrolase 3.25179
FAM43B family with sequence similarity 43, member B 3.25179
EDAR ectodysplasin A receptor 3.25179
S100G S100 calcium binding protein G 3.25179
C7ORF57 chromosome 7 open reading frame 57 3.25179
CAPN8 calpain 8 3.25179
TMEM40 transmembrane protein 40 3.25179
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.25179
RTL1 retrotransposon-like 1 3.25179
ZNF705D zinc finger protein 705D 3.25179
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.25179
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 3.25179
SMCP sperm mitochondria-associated cysteine-rich protein 3.25179
NPIPB8 nuclear pore complex interacting protein family, member B8 3.25179
VCX3A variable charge, X-linked 3A 3.25179
HBA2 hemoglobin, alpha 2 3.25179
NLRP6 NLR family, pyrin domain containing 6 3.25179
PAGE4 P antigen family, member 4 (prostate associated) 3.25179
RESP18 regulated endocrine-specific protein 18 3.25179
BTNL3 butyrophilin-like 3 3.25179
UTS2B urotensin 2B 3.25179
FCRLB Fc receptor-like B 3.25179
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.25179
CDC20B cell division cycle 20B 3.25179
DLX6 distal-less homeobox 6 3.25179
ZBP1 Z-DNA binding protein 1 3.25179
C18ORF63 chromosome 18 open reading frame 63 3.25179
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.25179
CD28 CD28 molecule 3.25179
IGFBP7 insulin-like growth factor binding protein 7 3.25179
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.25179
RSAD2 radical S-adenosyl methionine domain containing 2 3.25179
CCNI2 cyclin I family, member 2 3.25179
RBBP8NL RBBP8 N-terminal like 3.25179
ARR3 arrestin 3, retinal (X-arrestin) 3.25179
MORN5 MORN repeat containing 5 3.25179
IFITM5 interferon induced transmembrane protein 5 3.25179
HRCT1 histidine rich carboxyl terminus 1 3.25179
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 3.25179
C11ORF16 chromosome 11 open reading frame 16 3.25179
C8G complement component 8, gamma polypeptide 3.25179
CALR3 calreticulin 3 3.25179
F2RL2 coagulation factor II (thrombin) receptor-like 2 3.25179
ITGA10 integrin, alpha 10 3.25179
ANKRD55 ankyrin repeat domain 55 3.25179
GCOM1 GRINL1A complex locus 1 3.25179
CATSPERH catsper channel auxiliary subunit eta 3.25179
CTAGE9 CTAGE family, member 9 3.25179
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.25179
CRYBB2 crystallin, beta B2 3.25179
DPRX divergent-paired related homeobox 3.25179
MEFV Mediterranean fever 3.25179
MYADML2 myeloid-associated differentiation marker-like 2 3.25179
IL25 interleukin 25 3.25179
ZNF648 zinc finger protein 648 3.25179
FAM25A family with sequence similarity 25, member A 3.25179
CCDC170 coiled-coil domain containing 170 3.25179
ADGRF4 adhesion G protein-coupled receptor F4 3.25179
POTEF POTE ankyrin domain family, member F 3.25179
DEFB134 defensin, beta 134 3.25179
FGF10 fibroblast growth factor 10 3.25179
OR52N2 olfactory receptor, family 52, subfamily N, member 2 3.25179
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.25179
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.25179
TTC36 tetratricopeptide repeat domain 36 3.25179
TGM4 transglutaminase 4 3.25179
BTLA B and T lymphocyte associated 3.25179
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 3.25179
PHACTR3 phosphatase and actin regulator 3 3.25179
OR4M2 olfactory receptor, family 4, subfamily M, member 2 3.25179
SMIM10 small integral membrane protein 10 3.25179
SHOX short stature homeobox 3.25179
SFTA2 surfactant associated 2 3.25179
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.25179
MFSD6L major facilitator superfamily domain containing 6-like 3.25179
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.25179
DRC7 dynein regulatory complex subunit 7 3.25179
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 3.25179
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 3.25179
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.25179
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.25179
GJC2 gap junction protein, gamma 2, 47kDa 3.25179
BTG4 B-cell translocation gene 4 3.25179
KIF4B kinesin family member 4B 3.25179
DEFB110 defensin, beta 110 3.25179
MAGEA11 melanoma antigen family A11 3.25179
CNOT9 CCR4-NOT transcription complex subunit 9 3.15376
FLAD1 flavin adenine dinucleotide synthetase 1 3.15201
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.14411
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 3.13486
NEO1 neogenin 1 2.93324
LRRC1 leucine rich repeat containing 1 2.87949
COL9A2 collagen, type IX, alpha 2 2.8006
PDCD7 programmed cell death 7 2.76709
SLC46A1 solute carrier family 46 (folate transporter), member 1 2.73361
TRMO tRNA methyltransferase O 2.71328
ZBTB26 zinc finger and BTB domain containing 26 2.67329
STC1 stanniocalcin 1 2.54389
NSG2 neuronal vesicle trafficking associated 2 2.47516
CPNE5 copine V 2.47189
ANO3 anoctamin 3 2.47189
NXPH2 neurexophilin 2 2.45958
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.45162
BCL7B B-cell CLL/lymphoma 7B 2.44592
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 2.43846
CA8 carbonic anhydrase VIII 2.43846
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 2.42147
TEX10 testis expressed 10 2.38631
CNTNAP2 contactin associated protein-like 2 2.38033
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 2.36756
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.33667
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 2.31724
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.31724
SH3KBP1 SH3-domain kinase binding protein 1 2.30885
AMD1 adenosylmethionine decarboxylase 1 2.30108
ZNF528 zinc finger protein 528 2.29772
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 2.2951
ATP13A3 ATPase type 13A3 2.28802
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 2.28636
IQCN IQ motif containing N 2.21277
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 2.20759
ZSCAN12 zinc finger and SCAN domain containing 12 2.20759
VN1R1 vomeronasal 1 receptor 1 2.19485
ALX3 ALX homeobox 3 2.19485
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.19485
FBLN7 fibulin 7 2.19485
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.19485
SCP2 sterol carrier protein 2 2.19485
PLAU plasminogen activator, urokinase 2.19485
STRIT1 small transmembrane regulator of ion transport 1 2.19485
DCTN1 dynactin 1 2.19485
PCDHA1 protocadherin alpha 1 2.19485
USP22 ubiquitin specific peptidase 22 2.16123
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.15353
HACL1 2-hydroxyacyl-CoA lyase 1 2.15353
SNCAIP synuclein, alpha interacting protein 2.12975
TCTN1 tectonic family member 1 2.12069
TNS2 tensin 2 2.12069
PARD3B par-3 family cell polarity regulator beta 2.11645
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 2.11502
CXCR4 chemokine (C-X-C motif) receptor 4 2.11502
AMIGO2 adhesion molecule with Ig-like domain 2 2.11502
LIN28A lin-28 homolog A (C. elegans) 2.11497
IER5 immediate early response 5 2.10026
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 2.09047
MADD MAP-kinase activating death domain 2.08623
UBR5 ubiquitin protein ligase E3 component n-recognin 5 2.07841
TMEM259 transmembrane protein 259 2.07691
KLF13 Kruppel-like factor 13 2.0635
UNC5D unc-5 homolog D (C. elegans) 2.06017
MMP26 matrix metallopeptidase 26 2.04828
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 2.03262
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 2.03075
GPATCH3 G patch domain containing 3 2.0238
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.01582
KLHL12 kelch-like family member 12 2.00595
IPO11 importin 11 2.00591

decreased expression

Symbol Name Standardized Value
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -3.25179
ASCL2 achaete-scute family bHLH transcription factor 2 -3.25179
ZBED6 zinc finger, BED-type containing 6 -3.25179
CHAD chondroadherin -3.25179
CD300A CD300a molecule -3.25179
HHIPL2 HHIP-like 2 -3.25179
ACKR4 atypical chemokine receptor 4 -3.25179
FZD9 frizzled class receptor 9 -3.25179
RORC RAR-related orphan receptor C -3.25179
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 -3.25179
APOB apolipoprotein B -3.25179
SNAI2 snail family zinc finger 2 -3.25179
CD300LF CD300 molecule-like family member f -3.25179
GPR20 G protein-coupled receptor 20 -3.25179
YPEL4 yippee-like 4 (Drosophila) -3.25179
AVPR1B arginine vasopressin receptor 1B -3.25179
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -3.25179
GDF9 growth differentiation factor 9 -3.25179
VCX3B variable charge, X-linked 3B -3.25179
ZC3H11C zinc finger CCCH-type containing 11C -3.25179
NDRG1 N-myc downstream regulated 1 -3.25179
PHB2 prohibitin 2 -3.25179
GDNF glial cell derived neurotrophic factor -3.25179
LRG1 leucine-rich alpha-2-glycoprotein 1 -3.25179
DUSP23 dual specificity phosphatase 23 -3.25179
SEMG1 semenogelin I -3.25179
GOLGA8R golgin A8 family, member R -3.25179
HSPA1L heat shock 70kDa protein 1-like -3.25179
CRHR1 corticotropin releasing hormone receptor 1 -3.25179
KRT222 keratin 222, type II -3.25179
ZNF750 zinc finger protein 750 -3.25179
CFP complement factor properdin -3.25179
CNR2 cannabinoid receptor 2 (macrophage) -3.25179
KLK14 kallikrein-related peptidase 14 -3.25179
COL17A1 collagen, type XVII, alpha 1 -3.25179
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 -3.25179
CCDC102A coiled-coil domain containing 102A -2.94827
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.94212
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide -2.91384
BOD1 biorientation of chromosomes in cell division 1 -2.91063
FRS3 fibroblast growth factor receptor substrate 3 -2.89318
RAB25 RAB25, member RAS oncogene family -2.86926
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.85729
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.85729
RTRAF RNA transcription, translation and transport factor -2.82263
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.74563
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -2.68221
JPT2 Jupiter microtubule associated homolog 2 -2.67329
LPAR3 lysophosphatidic acid receptor 3 -2.66802
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.53231
OR3A2 olfactory receptor, family 3, subfamily A, member 2 -2.50935
ZSCAN32 zinc finger and SCAN domain containing 32 -2.50935
FBRS fibrosin -2.50935
ZNHIT3 zinc finger, HIT-type containing 3 -2.50251
MRPS31 mitochondrial ribosomal protein S31 -2.49833
NISCH nischarin -2.46062
NAGA N-acetylgalactosaminidase, alpha- -2.45958
NELL2 NEL-like 2 (chicken) -2.43239
LUC7L2 LUC7-like 2 (S. cerevisiae) -2.40817
LRP5 low density lipoprotein receptor-related protein 5 -2.38403
OLFM2 olfactomedin 2 -2.36855
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.36108
FLT3 fms-related tyrosine kinase 3 -2.34399
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -2.31699
PELI3 pellino E3 ubiquitin protein ligase family member 3 -2.31296
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.31043
NBPF8 neuroblastoma breakpoint family, member 8 -2.30846
JAKMIP1 janus kinase and microtubule interacting protein 1 -2.29772
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -2.25735
GLCCI1 glucocorticoid induced 1 -2.25716
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.22684
TMEM64 transmembrane protein 64 -2.22595
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.2123
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.20724
SF3B4 splicing factor 3b, subunit 4, 49kDa -2.16373
RAMACL RNA guanine-7 methyltransferase activating subunit like -2.16373
IL6ST-DT IL6ST divergent transcript -2.16373
RAB27B RAB27B, member RAS oncogene family -2.16373
TCF3 transcription factor 3 -2.16123
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -2.12346
VPS13B vacuolar protein sorting 13 homolog B (yeast) -2.12137
SRRM2 serine/arginine repetitive matrix 2 -2.11502
ODAD3 outer dynein arm docking complex subunit 3 -2.10176
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -2.10026
SLC35F1 solute carrier family 35, member F1 -2.10026
PHAF1 phagosome assembly factor 1 -2.09583
CPE carboxypeptidase E -2.0807
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -2.07927
CLDN10 claudin 10 -2.07841
PNISR PNN-interacting serine/arginine-rich protein -2.07691
MYCBPAP MYCBP associated protein -2.07691
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -2.06763
GPRASP2 G protein-coupled receptor associated sorting protein 2 -2.06407
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) -2.0635
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae) -2.03672
MTRF1 mitochondrial translational release factor 1 -2.03464
RPL12 ribosomal protein L12 -2.03297
AGBL5 ATP/GTP binding protein-like 5 -2.03262
OAT ornithine aminotransferase -2.03262
PRR13 proline rich 13 -2.03075
RO60 Ro60, Y RNA binding protein -2.0238
ZNF224 zinc finger protein 224 -2.0238
IL10RB interleukin 10 receptor, beta -2.00595
NUP54 nucleoporin 54kDa -2.00595
GOLGA6L9 golgin A6 family-like 9 -2.00595
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -2.00595
DPY19L4 dpy-19-like 4 (C. elegans) -2.00591