DAP Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description death-associated protein|This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 1611)
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Genes

344 genes differentially expressed following the DAP gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TRH thyrotropin-releasing hormone 3.19516
LCN12 lipocalin 12 3.19516
CPB1 carboxypeptidase B1 (tissue) 3.19516
ANKK1 ankyrin repeat and kinase domain containing 1 3.19516
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.19516
DLL4 delta-like 4 (Drosophila) 3.19516
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.19516
SETSIP SET-like protein 3.19516
FAM216B family with sequence similarity 216, member B 3.19516
C9ORF152 chromosome 9 open reading frame 152 3.19516
PCDH8 protocadherin 8 3.19516
RAPSN receptor-associated protein of the synapse 3.19516
SOX17 SRY (sex determining region Y)-box 17 3.19516
PGBDF plakoglobin binding and degradation factor 3.19516
SIRPB2 signal-regulatory protein beta 2 3.19516
IL5RA interleukin 5 receptor, alpha 3.19516
FOLR2 folate receptor 2 (fetal) 3.19516
CA6 carbonic anhydrase VI 3.19516
TRIM77 tripartite motif containing 77 3.19516
THRSP thyroid hormone responsive 3.19516
LGALS4 lectin, galactoside-binding, soluble, 4 3.19516
ACY3 aminoacylase 3 3.19516
PITX3 paired-like homeodomain 3 3.19516
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.19516
IRX4 iroquois homeobox 4 3.19516
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.19516
DEFB123 defensin, beta 123 3.19516
NLRP5 NLR family, pyrin domain containing 5 3.19516
VWC2L von Willebrand factor C domain containing protein 2-like 3.19516
FOXG1 forkhead box G1 3.19516
R3HDML R3H domain containing-like 3.19516
ZC2HC1B zinc finger, C2HC-type containing 1B 3.19516
RBP4 retinol binding protein 4, plasma 3.19516
RTP4 receptor (chemosensory) transporter protein 4 3.19516
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.19516
SPAG8 sperm associated antigen 8 3.19516
ZNF804A zinc finger protein 804A 3.19516
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.19516
SMCO1 single-pass membrane protein with coiled-coil domains 1 3.19516
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.19516
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.19516
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.19516
GPR55 G protein-coupled receptor 55 3.19516
CATSPERH catsper channel auxiliary subunit eta 3.19516
TFF2 trefoil factor 2 3.19516
PROX2 prospero homeobox 2 3.19516
SAG S-antigen; retina and pineal gland (arrestin) 3.19516
MYL10 myosin, light chain 10, regulatory 3.19516
RTL1 retrotransposon-like 1 3.19516
VSIG8 V-set and immunoglobulin domain containing 8 3.19516
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 3.19516
GATA1 GATA binding protein 1 (globin transcription factor 1) 3.19516
STMN4 stathmin-like 4 3.19516
AVPR1A arginine vasopressin receptor 1A 3.19516
GBP2 guanylate binding protein 2, interferon-inducible 3.19516
CIMIP4 ciliary microtubule inner protein 4 3.19516
TBC1D3I TBC1 domain family member 3I 3.19516
H3C13 H3 clustered histone 13 3.19516
MEIOSIN meiosis initiator 3.19516
GSTT4 glutathione S-transferase theta 4 3.19516
H1-8 H1.8 linker histone 3.19516
CFAP65 cilia and flagella associated protein 65 3.19516
H1-6 H1.6 linker histone, cluster member 3.19516
GATA5 GATA binding protein 5 3.19516
BEST3 bestrophin 3 3.19516
TMEM95 transmembrane protein 95 3.19516
SECTM1 secreted and transmembrane 1 3.19516
FRMD7 FERM domain containing 7 3.19516
TBX20 T-box 20 3.19516
MEP1B meprin A, beta 3.19516
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.19516
SBK3 SH3 domain binding kinase family, member 3 3.19516
LAX1 lymphocyte transmembrane adaptor 1 3.19516
PCDHB11 protocadherin beta 11 3.19516
DSG1 desmoglein 1 3.19516
IL31RA interleukin 31 receptor A 3.19516
WNT9B wingless-type MMTV integration site family, member 9B 3.19516
FGFBP2 fibroblast growth factor binding protein 2 3.19516
FMR1NB fragile X mental retardation 1 neighbor 3.19516
GTSF1 gametocyte specific factor 1 3.19516
DEFB104A defensin, beta 104A 3.19516
SCRT1 scratch family zinc finger 1 3.19516
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.19516
CXCL11 chemokine (C-X-C motif) ligand 11 3.19516
ZNF503 zinc finger protein 503 3.19516
PHACTR3 phosphatase and actin regulator 3 3.19516
ODF1 outer dense fiber of sperm tails 1 3.19516
TRIM50 tripartite motif containing 50 3.19516
CD52 CD52 molecule 3.19516
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.19516
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.19516
RNASE13 ribonuclease, RNase A family, 13 (non-active) 3.19516
PCDHGA3 protocadherin gamma subfamily A, 3 3.19516
CDHR5 cadherin-related family member 5 3.19516
ANKRD63 ankyrin repeat domain 63 3.19516
CXCR2 chemokine (C-X-C motif) receptor 2 3.19516
HHATL hedgehog acyltransferase-like 3.19516
C11ORF96 chromosome 11 open reading frame 96 3.19516
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 3.19516
GPR12 G protein-coupled receptor 12 3.19516
ZBP1 Z-DNA binding protein 1 3.19516
CCL27 chemokine (C-C motif) ligand 27 3.19516
NUPR1 nuclear protein, transcriptional regulator, 1 3.19516
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.19516
NPY2R neuropeptide Y receptor Y2 3.19516
ADAM18 ADAM metallopeptidase domain 18 3.19516
CCNA1 cyclin A1 3.19516
TYR tyrosinase 3.19516
GSC2 goosecoid homeobox 2 3.19516
GCGR glucagon receptor 3.19516
QRFP pyroglutamylated RFamide peptide 3.19516
PRSS33 protease, serine, 33 3.19516
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.19516
PRR33 proline rich 33 3.19516
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 3.19516
KLK15 kallikrein-related peptidase 15 3.19516
C8ORF89 chromosome 8 open reading frame 89 3.19516
PLA1A phospholipase A1 member A 3.19516
CLEC18C C-type lectin domain family 18, member C 3.19516
C17ORF99 chromosome 17 open reading frame 99 3.19516
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.19516
ANXA8 annexin A8 3.19516
RUFY4 RUN and FYVE domain containing 4 3.19516
NTSR2 neurotensin receptor 2 3.19516
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.19516
MAEL maelstrom spermatogenic transposon silencer 3.19516
EPX eosinophil peroxidase 3.19516
ADGRF1 adhesion G protein-coupled receptor F1 3.19516
PXT1 peroxisomal, testis specific 1 3.19516
NPAS4 neuronal PAS domain protein 4 3.19516
GRAPL GRB2-related adaptor protein-like 3.19516
MOBP myelin-associated oligodendrocyte basic protein 3.19516
FOXP3 forkhead box P3 3.19516
TMEM45B transmembrane protein 45B 3.19516
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.19516
LYZL2 lysozyme-like 2 3.19516
NEU4 sialidase 4 3.19516
ANXA1 annexin A1 3.19516
TSPAN32 tetraspanin 32 3.19516
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.19516
TAS2R46 taste receptor, type 2, member 46 3.19516
PLA2G4D phospholipase A2, group IVD (cytosolic) 3.19516
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.19516
C11ORF42 chromosome 11 open reading frame 42 3.16443
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 3.04653
MARVELD1 MARVEL domain containing 1 3.03021
SWI5 SWI5 recombination repair homolog (yeast) 3.01549
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.99999
RFC2 replication factor C (activator 1) 2, 40kDa 2.99999
OTOF otoferlin 2.99999
HMGXB4 HMG box domain containing 4 2.96143
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.82882
C2ORF42 chromosome 2 open reading frame 42 2.78856
ZYX zyxin 2.6865
ZNF16 zinc finger protein 16 2.59376
RIPOR3 RIPOR family member 3 2.57983
HNF4A hepatocyte nuclear factor 4, alpha 2.55601
DVL2 dishevelled segment polarity protein 2 2.49322
MRPL55 mitochondrial ribosomal protein L55 2.46455
NAP1L4 nucleosome assembly protein 1-like 4 2.45261
RGS7 regulator of G-protein signaling 7 2.42964
GLA galactosidase, alpha 2.42116
UNC5C unc-5 homolog C (C. elegans) 2.4115
CSNK1G3 casein kinase 1, gamma 3 2.40032
CD80 CD80 molecule 2.39581
AOC1 amine oxidase, copper containing 1 2.3902
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 2.37597
CSMD3 CUB and Sushi multiple domains 3 2.34861
LTBP2 latent transforming growth factor beta binding protein 2 2.34861
OSR2 odd-skipped related transciption factor 2 2.33608
OOEP oocyte expressed protein 2.32002
CTTNBP2 cortactin binding protein 2 2.30942
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 2.28098
ACOT2 acyl-CoA thioesterase 2 2.27913
BTF3 basic transcription factor 3 2.2075
PARP16 poly (ADP-ribose) polymerase family, member 16 2.20325
NCKAP5L NCK-associated protein 5-like 2.19961
RAB11FIP4 RAB11 family interacting protein 4 (class II) 2.17961
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 2.16478
NBDY negative regulator of P-body association 2.1566
SNRPG small nuclear ribonucleoprotein polypeptide G 2.13835
SETD6 SET domain containing 6 2.13743
GOLGA6L9 golgin A6 family-like 9 2.1331
BRCA1 breast cancer 1, early onset 2.1331
PVALB parvalbumin 2.1331
NOMO3 NODAL modulator 3 2.12414
PNMA6A paraneoplastic Ma antigen family member 6A 2.11625
SS18 synovial sarcoma translocation, chromosome 18 2.10932
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.10721
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.10721
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.10009
GLP1R glucagon-like peptide 1 receptor 2.09925
FNDC10 fibronectin type III domain containing 10 2.0966
TEX9 testis expressed 9 2.0966
THAP3 THAP domain containing, apoptosis associated protein 3 2.09304
ZNF248 zinc finger protein 248 2.09303
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.08464
TTBK1 tau tubulin kinase 1 2.08464
DYNLT2 dynein light chain Tctex-type 2 2.08464
LRRC75A leucine rich repeat containing 75A 2.08464
PDPN podoplanin 2.07408
SEC61B Sec61 beta subunit 2.06879
GAB2 GRB2-associated binding protein 2 2.0684
DOCK11 dedicator of cytokinesis 11 2.05392
CCDC150 coiled-coil domain containing 150 2.04295
RNF146 ring finger protein 146 2.03709
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.02983
BCL10 B-cell CLL/lymphoma 10 2.02279
MMS22L MMS22-like, DNA repair protein 2.01721
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 2.015
ITGB4 integrin, beta 4 2.015
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 2.01453
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.01453
LRRC34 leucine rich repeat containing 34 2.00852
SAR1A secretion associated, Ras related GTPase 1A 2.00852

decreased expression

Symbol Name Standardized Value
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -3.19516
MRPL1 mitochondrial ribosomal protein L1 -3.19516
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -3.19516
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -3.19516
COQ6 coenzyme Q6 monooxygenase -3.19516
ACTR8 ARP8 actin-related protein 8 homolog (yeast) -3.19516
ACP4 acid phosphatase 4 -3.19516
KIRREL2 kin of IRRE like 2 (Drosophila) -3.19516
H3C4 H3 clustered histone 4 -3.19516
CAMTA2 calmodulin binding transcription activator 2 -3.02934
C3ORF80 chromosome 3 open reading frame 80 -2.99999
MUC20 mucin 20, cell surface associated -2.99999
TRPC5OS TRPC5 opposite strand -2.99999
FAM181B family with sequence similarity 181, member B -2.99999
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 -2.99999
GPR78 G protein-coupled receptor 78 -2.99999
DSPP dentin sialophosphoprotein -2.99999
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -2.99999
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.99999
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -2.99999
GH2 growth hormone 2 -2.99999
SPATA31H1 SPATA31 subfamily H member 1 -2.99999
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -2.99999
TNS1-AS1 TNS1 antisense RNA 1 -2.99999
CFAP90 cilia and flagella associated protein 90 -2.99999
CCN5 cellular communication network factor 5 -2.99999
ALDOB aldolase B, fructose-bisphosphate -2.99999
MCHR1 melanin-concentrating hormone receptor 1 -2.99999
AANAT aralkylamine N-acetyltransferase -2.99999
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.99999
TMEM190 transmembrane protein 190 -2.99999
ARMC8 armadillo repeat containing 8 -2.99999
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.99999
NXPE1 neurexophilin and PC-esterase domain family, member 1 -2.99999
PCDHA3 protocadherin alpha 3 -2.99999
ACTL10 actin-like 10 -2.99999
NUTM2A NUT family member 2A -2.99999
GOLGA6C golgin A6 family, member C -2.99999
NT5C1B 5'-nucleotidase, cytosolic IB -2.99999
TTC9B tetratricopeptide repeat domain 9B -2.99999
F11 coagulation factor XI -2.99999
TEX19 testis expressed 19 -2.99999
RSAD2 radical S-adenosyl methionine domain containing 2 -2.99999
FKBP1C FK506 binding protein 1C -2.99999
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.99999
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -2.99999
SPEF1 sperm flagellar 1 -2.99999
CFB complement factor B -2.99999
EGLN2 egl-9 family hypoxia-inducible factor 2 -2.98359
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.88297
C19ORF73 chromosome 19 open reading frame 73 -2.88297
KLHDC8A kelch domain containing 8A -2.863
IGSF1 immunoglobulin superfamily, member 1 -2.863
SCARA5 scavenger receptor class A, member 5 -2.863
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 -2.863
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.81974
COL4A2 collagen, type IV, alpha 2 -2.7664
OPA1 optic atrophy 1 (autosomal dominant) -2.74698
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.69306
EPAS1 endothelial PAS domain protein 1 -2.60446
PI4KB phosphatidylinositol 4-kinase, catalytic, beta -2.57983
RBP5 retinol binding protein 5, cellular -2.53035
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 -2.47921
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -2.46455
MITF microphthalmia-associated transcription factor -2.43797
CBX4 chromobox homolog 4 -2.42964
INHA inhibin, alpha -2.39581
MED24 mediator complex subunit 24 -2.39581
SYT14 synaptotagmin XIV -2.38265
GOLIM4 golgi integral membrane protein 4 -2.37826
RIC8B RIC8 guanine nucleotide exchange factor B -2.37702
BMERB1 bMERB domain containing 1 -2.34861
RGPD6 RANBP2-like and GRIP domain containing 6 -2.3403
JADE2 jade family PHD finger 2 -2.3379
IPO11 importin 11 -2.33704
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -2.32984
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.32506
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -2.31418
HNRNPA1L3 heterogeneous nuclear ribonucleoprotein A1 like 3 -2.30575
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 -2.30155
ZNF625 zinc finger protein 625 -2.29524
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 -2.28165
AGBL1 ATP/GTP binding protein-like 1 -2.28013
ZBED8L ZBED8 like -2.27913
KLHL36 kelch-like family member 36 -2.25766
ZFR2 zinc finger RNA binding protein 2 -2.22238
PCDHGB7 protocadherin gamma subfamily B, 7 -2.22016
RAD18 RAD18 E3 ubiquitin protein ligase -2.21886
PLAC8 placenta-specific 8 -2.21397
C11ORF86 chromosome 11 open reading frame 86 -2.21397
ZBBX zinc finger, B-box domain containing -2.21397
ZNF14 zinc finger protein 14 -2.21397
RGPD1 RANBP2-like and GRIP domain containing 1 -2.21397
NCMAP noncompact myelin associated protein -2.21397
ARHGAP31 Rho GTPase activating protein 31 -2.2075
DUSP3 dual specificity phosphatase 3 -2.20001
DNLZ DNL-type zinc finger -2.20001
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae) -2.17961
CERT1 ceramide transporter 1 -2.17961
ZSCAN9 zinc finger and SCAN domain containing 9 -2.17961
ZNF605 zinc finger protein 605 -2.17506
ISG15 ISG15 ubiquitin-like modifier -2.17506
SEC62 SEC62 homolog (S. cerevisiae) -2.16478
AACS acetoacetyl-CoA synthetase -2.1566
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -2.14079
FXYD3 FXYD domain containing ion transport regulator 3 -2.13835
SYCP3 synaptonemal complex protein 3 -2.13835
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) -2.1331
RBM17 RNA binding motif protein 17 -2.12414
MMD2 monocyte to macrophage differentiation-associated 2 -2.10721
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.1069
RAB9B RAB9B, member RAS oncogene family -2.1069
SOS1 son of sevenless homolog 1 (Drosophila) -2.1069
SREBF1 sterol regulatory element binding transcription factor 1 -2.10009
ZNF774 zinc finger protein 774 -2.0966
LOXL4 lysyl oxidase-like 4 -2.0966
FBLN7 fibulin 7 -2.0966
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.0966
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.0966
CHMP6 charged multivesicular body protein 6 -2.08464
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.08464
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 -2.08464
NCOA3 nuclear receptor coactivator 3 -2.0684
MTLN mitoregulin -2.05452
GEMIN8 gem (nuclear organelle) associated protein 8 -2.0454
TCF24 transcription factor 24 -2.02333
KIF5B kinesin family member 5B -2.015
RAMAC RNA guanine-7 methyltransferase activating subunit -2.00771
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.00582