DAPK1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description death-associated protein kinase 1|Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 1612)
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Genes

346 genes differentially expressed following the DAPK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.43076
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.43076
SLC46A2 solute carrier family 46, member 2 3.43076
KLRK1 killer cell lectin-like receptor subfamily K, member 1 3.43076
MAGEA1 melanoma antigen family A1 3.43076
CD163 CD163 molecule 3.43076
PCDHB8 protocadherin beta 8 3.43076
TM4SF1 transmembrane 4 L six family member 1 3.43076
PCDHGB3 protocadherin gamma subfamily B, 3 3.43076
SLC25A41 solute carrier family 25, member 41 3.43076
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.43076
SCGN secretagogin, EF-hand calcium binding protein 3.43076
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 3.43076
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.43076
PTPRC protein tyrosine phosphatase, receptor type, C 3.43076
PCDHA7 protocadherin alpha 7 3.43076
HHEX hematopoietically expressed homeobox 3.43076
USH1G Usher syndrome 1G (autosomal recessive) 3.43076
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.43076
CD5 CD5 molecule 3.43076
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.43076
PARP3 poly (ADP-ribose) polymerase family, member 3 3.43076
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.43076
PAX3 paired box 3 3.43076
TYRP1 tyrosinase-related protein 1 3.43076
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 3.43076
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.43076
FAM9B family with sequence similarity 9, member B 3.43076
TPH1 tryptophan hydroxylase 1 3.43076
ANXA2R annexin A2 receptor 3.43076
CD22 CD22 molecule 3.43076
MRGPRX3 MAS-related GPR, member X3 3.43076
ANKRD30A ankyrin repeat domain 30A 3.43076
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.43076
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.43076
ICAM2 intercellular adhesion molecule 2 3.43076
GYS2 glycogen synthase 2 (liver) 3.43076
SPI1 Spi-1 proto-oncogene 3.43076
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.43076
TAL2 T-cell acute lymphocytic leukemia 2 3.43076
SFTPC surfactant protein C 3.43076
TDRD9 tudor domain containing 9 3.43076
RGPD3 RANBP2-like and GRIP domain containing 3 3.43076
KIF2B kinesin family member 2B 3.43076
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.43076
MISP mitotic spindle positioning 3.43076
HBZ hemoglobin, zeta 3.43076
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 3.43076
NLRP4 NLR family, pyrin domain containing 4 3.43076
WNT11 wingless-type MMTV integration site family, member 11 3.43076
SMIM39 small integral membrane protein 39 3.43076
TMEM275 transmembrane protein 275 3.43076
NECTIN4 nectin cell adhesion molecule 4 3.43076
TMOD4 tropomodulin 4 (muscle) 3.43076
HAO2 hydroxyacid oxidase 2 (long chain) 3.43076
PCDHGA9 protocadherin gamma subfamily A, 9 3.43076
AVPR1B arginine vasopressin receptor 1B 3.43076
CD300LF CD300 molecule-like family member f 3.43076
MGAT4D MGAT4 family, member D 3.43076
TMIGD1 transmembrane and immunoglobulin domain containing 1 3.43076
TMPRSS6 transmembrane protease, serine 6 3.43076
SPACDR sperm acrosome developmental regulator 3.43076
H2BW1 H2B.W histone 1 3.43076
SPMIP11 sperm microtubule inner protein 11 3.43076
EPCIP exosomal polycystin 1 interacting protein 3.43076
PRR20G proline rich 20G 3.43076
LINC02268 long intergenic non-protein coding RNA 2268 3.43076
C17ORF113 chromosome 17 open reading frame 113 3.43076
H2BC12L H2B clustered histone 12 like 3.43076
H3-7 H3.7 histone (putative) 3.43076
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 3.43076
SERTM2 serine rich and transmembrane domain containing 2 3.43076
CLEC20A C-type lectin domain containing 20A 3.43076
PAPOLB poly(A) polymerase beta (testis specific) 3.43076
XKR3 XK, Kell blood group complex subunit-related family, member 3 3.43076
CFC1 cripto, FRL-1, cryptic family 1 3.43076
PGC progastricsin (pepsinogen C) 3.43076
TPTE transmembrane phosphatase with tensin homology 3.43076
TLR1 toll-like receptor 1 3.43076
NHLRC4 NHL repeat containing 4 3.43076
IL5 interleukin 5 3.43076
C1ORF162 chromosome 1 open reading frame 162 3.43076
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 3.43076
MSX2 msh homeobox 2 3.43076
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.43076
CD48 CD48 molecule 3.43076
KLRF2 killer cell lectin-like receptor subfamily F, member 2 3.43076
FAM186B family with sequence similarity 186, member B 3.43076
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.43076
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.43076
CNTN6 contactin 6 3.43076
ZNF683 zinc finger protein 683 3.43076
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.43076
COX8C cytochrome c oxidase subunit VIIIC 3.43076
LRRC71 leucine rich repeat containing 71 3.43076
C7ORF57 chromosome 7 open reading frame 57 3.43076
RGS21 regulator of G-protein signaling 21 3.43076
CCR3 chemokine (C-C motif) receptor 3 3.43076
ZSWIM2 zinc finger, SWIM-type containing 2 3.43076
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.43076
GFI1B growth factor independent 1B transcription repressor 3.43076
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 3.43076
MAB21L1 mab-21-like 1 (C. elegans) 3.43076
TRIM55 tripartite motif containing 55 3.43076
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 3.43076
MUC13 mucin 13, cell surface associated 3.43076
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.43076
ISL2 ISL LIM homeobox 2 3.43076
COL17A1 collagen, type XVII, alpha 1 3.43076
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.43076
CALHM3 calcium homeostasis modulator 3 3.43076
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.43076
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 3.43076
COMP cartilage oligomeric matrix protein 3.43076
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 3.43076
CH25H cholesterol 25-hydroxylase 3.43076
ERICH4 glutamate-rich 4 3.43076
EDN1 endothelin 1 3.43076
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.43076
C11ORF97 chromosome 11 open reading frame 97 3.43076
CYSLTR1 cysteinyl leukotriene receptor 1 3.43076
MIEF2 mitochondrial elongation factor 2 3.43076
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.43076
COL6A5 collagen, type VI, alpha 5 3.43076
CATIP ciliogenesis associated TTC17 interacting protein 3.43076
GSC2 goosecoid homeobox 2 3.43076
LGALS12 lectin, galactoside-binding, soluble, 12 3.43076
ERVV-2 endogenous retrovirus group V, member 2 3.43076
POU4F3 POU class 4 homeobox 3 3.43076
POU4F1 POU class 4 homeobox 1 3.43076
OR8J1 olfactory receptor, family 8, subfamily J, member 1 3.43076
WNT10B wingless-type MMTV integration site family, member 10B 3.43076
GOLGA8K golgin A8 family, member K 3.43076
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.43076
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae) 3.43076
IDI2 isopentenyl-diphosphate delta isomerase 2 3.43076
DLX6 distal-less homeobox 6 3.43076
MLIP muscular LMNA-interacting protein 3.43076
TEX12 testis expressed 12 3.43076
SST somatostatin 3.43076
SAMD7 sterile alpha motif domain containing 7 3.43076
SPEF1 sperm flagellar 1 3.43076
TF transferrin 3.43076
TH tyrosine hydroxylase 3.43076
CFB complement factor B 3.43076
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.43076
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 3.43076
PSORS1C2 psoriasis susceptibility 1 candidate 2 3.43076
APOL3 apolipoprotein L, 3 3.43076
HMX3 H6 family homeobox 3 3.43076
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.43076
WDFY4 WDFY family member 4 3.43076
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 3.43076
HHIPL2 HHIP-like 2 3.43076
RNF224 ring finger protein 224 3.43076
PTCRA pre T-cell antigen receptor alpha 3.43076
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.43076
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 3.43076
AQP1 aquaporin 1 (Colton blood group) 3.43076
CLCA1 chloride channel accessory 1 3.43076
LRRC74A leucine rich repeat containing 74A 3.43076
ARGFX arginine-fifty homeobox 3.43076
ANGPTL6 angiopoietin-like 6 3.43076
IL17D interleukin 17D 3.43076
PRF1 perforin 1 (pore forming protein) 3.43076
BANF2 barrier to autointegration factor 2 3.43076
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.43076
LRRC43 leucine rich repeat containing 43 3.43076
ADAM29 ADAM metallopeptidase domain 29 3.43076
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.43076
OR3A3 olfactory receptor, family 3, subfamily A, member 3 3.43076
CIDEA cell death-inducing DFFA-like effector a 3.43076
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.43076
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.43076
LDLRAD2 low density lipoprotein receptor class A domain containing 2 3.40124
CALML4 calmodulin-like 4 3.28995
VASN vasorin 3.21186
XIRP2 xin actin binding repeat containing 2 3.0928
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.95953
LTC4S leukotriene C4 synthase 2.95953
GARNL3 GTPase activating Rap/RanGAP domain-like 3 2.87365
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.86586
STC1 stanniocalcin 1 2.78378
COMMD1 copper metabolism (Murr1) domain containing 1 2.74067
EXTL2 exostosin-like glycosyltransferase 2 2.73551
RAD1 RAD1 checkpoint DNA exonuclease 2.66851
SUSD5 sushi domain containing 5 2.61831
TTPAL tocopherol (alpha) transfer protein-like 2.61007
FIGNL1 fidgetin-like 1 2.60234
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.51362
DGKD diacylglycerol kinase, delta 130kDa 2.5028
SDC2 syndecan 2 2.4753
ZCCHC10 zinc finger, CCHC domain containing 10 2.47433
MRPS17 mitochondrial ribosomal protein S17 2.46335
TLCD4 TLC domain containing 4 2.46335
CNR1 cannabinoid receptor 1 (brain) 2.44472
H3C1 H3 clustered histone 1 2.43519
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.40615
CAPN9 calpain 9 2.40272
H1-3 H1.3 linker histone, cluster member 2.401
GYS1 glycogen synthase 1 (muscle) 2.39501
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 2.38456
ISM2 isthmin 2 2.36449
MRM2 mitochondrial rRNA methyltransferase 2 2.36148
KLHL4 kelch-like family member 4 2.35837
OLAH oleoyl-ACP hydrolase 2.29281
TTC8 tetratricopeptide repeat domain 8 2.28536
COA5 cytochrome c oxidase assembly factor 5 2.26335
CDIP1 cell death-inducing p53 target 1 2.25175
TMEM234 transmembrane protein 234 2.2506
RBMX RNA binding motif protein, X-linked 2.2477
ZNF561 zinc finger protein 561 2.24216
MYB v-myb avian myeloblastosis viral oncogene homolog 2.22239
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.21186
PARP8 poly (ADP-ribose) polymerase family, member 8 2.19757
PKD2 polycystic kidney disease 2 (autosomal dominant) 2.19337
WDR91 WD repeat domain 91 2.19091
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.16078
SEPTIN10 septin 10 2.13821
STAMBP STAM binding protein 2.13137
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 2.12953
RAB5B RAB5B, member RAS oncogene family 2.12953
H2AC14 H2A clustered histone 14 2.10753
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 2.08906
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.06592
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 2.05672
NDFIP1 Nedd4 family interacting protein 1 2.05501
PDGFB platelet-derived growth factor beta polypeptide 2.04812
PCNA proliferating cell nuclear antigen 2.03461
RAB9A RAB9A, member RAS oncogene family 2.00859
CISD2 CDGSH iron sulfur domain 2 2.00683
METRNL meteorin, glial cell differentiation regulator-like 2.00683
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.00683
PAK1IP1 PAK1 interacting protein 1 2.00544
EID2B EP300 interacting inhibitor of differentiation 2B 2.00144
CLDN11 claudin 11 2.00086

decreased expression

Symbol Name Standardized Value
CRHR1 corticotropin releasing hormone receptor 1 -3.43076
PRSS53 protease, serine, 53 -3.43076
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -3.43076
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -3.43076
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2 -3.43076
PEBP4 phosphatidylethanolamine-binding protein 4 -3.43076
CSMD1 CUB and Sushi multiple domains 1 -3.41626
LMOD2 leiomodin 2 (cardiac) -3.40124
TTC9B tetratricopeptide repeat domain 9B -3.40124
TUBB1 tubulin, beta 1 class VI -3.40124
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 -3.40124
GMNC geminin coiled-coil domain containing -3.40124
GRK7 G protein-coupled receptor kinase 7 -3.40124
HES2 hes family bHLH transcription factor 2 -3.40124
EDN3 endothelin 3 -3.40124
OR56A4 olfactory receptor, family 56, subfamily A, member 4 -3.40124
GOLGA8M golgin A8 family, member M -3.40124
RNF112 ring finger protein 112 -3.40124
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -3.40124
LOC107986837 uncharacterized LOC107986837 -3.40124
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -3.40124
AJM1 apical junction component 1 homolog -3.40124
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H -3.40124
GRAP GRB2-related adaptor protein -3.40124
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 -3.40124
CELA2A chymotrypsin-like elastase family, member 2A -3.40124
TACSTD2 tumor-associated calcium signal transducer 2 -3.40124
CATSPERD catsper channel auxiliary subunit delta -3.40124
CKM creatine kinase, muscle -3.40124
XKRX XK, Kell blood group complex subunit-related, X-linked -3.40124
FGR FGR proto-oncogene, Src family tyrosine kinase -3.40124
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -3.40124
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -3.31321
ATXN7L3 ataxin 7-like 3 -3.22467
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -3.0928
EED embryonic ectoderm development -3.0928
EZR ezrin -3.0471
TTC3 tetratricopeptide repeat domain 3 -3.02569
EPN3 epsin 3 -3.01942
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.97808
DAPK1 death-associated protein kinase 1 -2.96463
MXRA5 matrix-remodelling associated 5 -2.84449
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -2.83327
GLRX5 glutaredoxin 5 -2.79948
EBNA1BP2 EBNA1 binding protein 2 -2.69106
ADGRV1 adhesion G protein-coupled receptor V1 -2.69098
TNS3 tensin 3 -2.6736
PROK2 prokineticin 2 -2.60756
SETD1A SET domain containing 1A -2.60292
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.60283
RPH3AL rabphilin 3A-like (without C2 domains) -2.60234
SPP1 secreted phosphoprotein 1 -2.5989
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.59049
FGFR1OP2 FGFR1 oncogene partner 2 -2.58664
UVRAG UV radiation resistance associated -2.58664
IVD isovaleryl-CoA dehydrogenase -2.55547
ARL9 ADP-ribosylation factor-like 9 -2.55168
ZNF507 zinc finger protein 507 -2.52632
ZNF574 zinc finger protein 574 -2.46335
SEZ6 seizure related 6 homolog (mouse) -2.43392
SEC13 SEC13 homolog (S. cerevisiae) -2.40272
NR5A2 nuclear receptor subfamily 5, group A, member 2 -2.39225
IL18 interleukin 18 -2.39225
PDE8B phosphodiesterase 8B -2.3847
BTNL8 butyrophilin-like 8 -2.36148
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 -2.35837
SORBS1 sorbin and SH3 domain containing 1 -2.35306
EPSTI1 epithelial stromal interaction 1 (breast) -2.34975
TMEM82 transmembrane protein 82 -2.33984
FAM76A family with sequence similarity 76, member A -2.28561
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.28561
PURB purine-rich element binding protein B -2.28561
LCTL lactase-like -2.28536
ZBED5 zinc finger, BED-type containing 5 -2.28536
TULP2 tubby like protein 2 -2.27798
MCM9 minichromosome maintenance complex component 9 -2.25175
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -2.25175
RUNX3 runt-related transcription factor 3 -2.2477
SOX7 SRY (sex determining region Y)-box 7 -2.2477
AOC3 amine oxidase, copper containing 3 -2.2477
TMEM79 transmembrane protein 79 -2.22401
ICAM5 intercellular adhesion molecule 5, telencephalin -2.22401
CARMIL2 capping protein regulator and myosin 1 linker 2 -2.22401
CSMD2 CUB and Sushi multiple domains 2 -2.22401
TRIM73 tripartite motif containing 73 -2.22401
TYMS thymidylate synthetase -2.22225
ZBTB4 zinc finger and BTB domain containing 4 -2.22225
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -2.22225
INTS4 integrator complex subunit 4 -2.20813
MGAT4C MGAT4 family, member C -2.19794
ZBED4 zinc finger, BED-type containing 4 -2.17126
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 -2.16291
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits -2.13137
STRA6 stimulated by retinoic acid 6 -2.12205
ODC1 ornithine decarboxylase 1 -2.11364
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) -2.10979
DUSP5 dual specificity phosphatase 5 -2.10964
MCRS1 microspherule protein 1 -2.10635
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.10635
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) -2.07883
PAK5 p21 (RAC1) activated kinase 5 -2.06568
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 -2.05244
REX1BD required for excision 1-B domain containing -2.03461
KDM7A lysine (K)-specific demethylase 7A -2.03461
CENPL centromere protein L -2.02847
SKA2 spindle and kinetochore associated complex subunit 2 -2.02384
PLN phospholamban -2.02328
KLHDC9 kelch domain containing 9 -2.0152
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.00683
DCAF16 DDB1 and CUL4 associated factor 16 -2.00144