DAXX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description death-domain associated protein|This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] (NCBI Entrez Gene Database, 1616)
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Genes

316 genes differentially expressed following the DAXX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GJA4 gap junction protein, alpha 4, 37kDa 2.41067
NOD2 nucleotide-binding oligomerization domain containing 2 2.41067
ERVK3-1 endogenous retrovirus group K3, member 1 2.41067
IL5RA interleukin 5 receptor, alpha 2.41067
DUSP10 dual specificity phosphatase 10 2.41067
PROB1 proline-rich basic protein 1 2.41067
WT1 Wilms tumor 1 2.41067
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.41067
CSMD3 CUB and Sushi multiple domains 3 2.41067
ADAM33 ADAM metallopeptidase domain 33 2.41067
PRL prolactin 2.41067
UPB1 ureidopropionase, beta 2.41067
ATXN7L2 ataxin 7-like 2 2.41067
HRH1 histamine receptor H1 2.41067
ELF4 E74-like factor 4 (ets domain transcription factor) 2.41067
LRRD1 leucine-rich repeats and death domain containing 1 2.41067
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.41067
CHADL chondroadherin-like 2.41067
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.41067
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.41067
PRELP proline/arginine-rich end leucine-rich repeat protein 2.41067
PDIA2 protein disulfide isomerase family A, member 2 2.41067
OR2A42 olfactory receptor, family 2, subfamily A, member 42 2.41067
MANSC4 MANSC domain containing 4 2.41067
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.41067
CHGB chromogranin B 2.41067
DLX4 distal-less homeobox 4 2.41067
ADAT3 adenosine deaminase, tRNA-specific 3 2.41067
S100A1 S100 calcium binding protein A1 2.41067
PNOC prepronociceptin 2.41067
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.41067
CHD5 chromodomain helicase DNA binding protein 5 2.41067
CPLX3 complexin 3 2.41067
TMC3 transmembrane channel-like 3 2.41067
OVCH2 ovochymase 2 (gene/pseudogene) 2.41067
ETV2 ets variant 2 2.41067
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.41067
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 2.41067
ASB12 ankyrin repeat and SOCS box containing 12 2.41067
ALPK2 alpha-kinase 2 2.41067
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.41067
THRSP thyroid hormone responsive 2.41067
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.41067
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.41067
RGL4 ral guanine nucleotide dissociation stimulator-like 4 2.41067
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.41067
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.41067
PTGER3 prostaglandin E receptor 3 (subtype EP3) 2.41067
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.41067
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.41067
SPMIP11 sperm microtubule inner protein 11 2.41067
C3AR1 complement component 3a receptor 1 2.41067
HPSE heparanase 2.41067
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 2.41067
SPI1 Spi-1 proto-oncogene 2.41067
FIMP1 fertilization-influencing membrane protein 1 2.41067
FMO2 flavin containing monooxygenase 2 (non-functional) 2.41067
PDF peptide deformylase (mitochondrial) 2.41067
MYZAP myocardial zonula adherens protein 2.41067
SRPK3 SRSF protein kinase 3 2.41067
RASD2 RASD family, member 2 2.41067
MAB21L4 mab-21 like 4 2.41067
CHCT1 CHD1 helical C-terminal domain containing 1 2.41067
SPMIP9 sperm microtubule inner protein 9 2.41067
DRC5 dynein regulatory complex subunit 5 2.41067
DUSP13B dual specificity phosphatase 13B 2.41067
CCDC194 coiled-coil domain containing 194 2.41067
GNG5B G protein subunit gamma 5B 2.41067
SMIM31 small integral membrane protein 31 2.41067
TUBB8B tubulin beta 8B 2.41067
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.41067
CFAP107 cilia and flagella associated protein 107 2.41067
CFAP206 cilia and flagella associated protein 206 2.41067
ZNF441 zinc finger protein 441 2.41067
LEKR1 leucine, glutamate and lysine rich 1 2.41067
CLEC6A C-type lectin domain family 6, member A 2.41067
PRRT4 proline-rich transmembrane protein 4 2.41067
BMI1 BMI1 proto-oncogene, polycomb ring finger 2.41067
SCRT2 scratch family zinc finger 2 2.41067
SIM2 single-minded family bHLH transcription factor 2 2.41067
COL6A6 collagen, type VI, alpha 6 2.41067
CCR6 chemokine (C-C motif) receptor 6 2.41067
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.41067
CLDN5 claudin 5 2.41067
VIT vitrin 2.41067
TMEM229A transmembrane protein 229A 2.41067
SPDYE17 speedy/RINGO cell cycle regulator family member E17 2.41067
CDKN2A cyclin-dependent kinase inhibitor 2A 2.41067
C4ORF50 chromosome 4 open reading frame 50 2.41067
SYT15 synaptotagmin XV 2.41067
CNTN3 contactin 3 (plasmacytoma associated) 2.41067
ASIC1 acid sensing (proton gated) ion channel 1 2.41067
PLEK2 pleckstrin 2 2.41067
FGFBP1 fibroblast growth factor binding protein 1 2.41067
ABHD15 abhydrolase domain containing 15 2.41067
PLB1 phospholipase B1 2.41067
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.41067
OVOL1 ovo-like zinc finger 1 2.41067
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.41067
APOH apolipoprotein H (beta-2-glycoprotein I) 2.41067
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.41067
ZSCAN10 zinc finger and SCAN domain containing 10 2.41067
HPX hemopexin 2.41067
SPINK9 serine peptidase inhibitor, Kazal type 9 2.41067
CD52 CD52 molecule 2.41067
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.41067
DRD3 dopamine receptor D3 2.41067
C2CD4B C2 calcium-dependent domain containing 4B 2.41067
C2CD4A C2 calcium-dependent domain containing 4A 2.41067
PCDHGA7 protocadherin gamma subfamily A, 7 2.41067
DCLK3 doublecortin-like kinase 3 2.41067
CYSLTR1 cysteinyl leukotriene receptor 1 2.41067
PCDHGB5 protocadherin gamma subfamily B, 5 2.41067
PCDHGB2 protocadherin gamma subfamily B, 2 2.41067
EBF4 early B-cell factor 4 2.41067
TMEM132D transmembrane protein 132D 2.41067
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.41067
EFCAB9 EF-hand calcium binding domain 9 2.41067
CCDC171 coiled-coil domain containing 171 2.41067
BTNL8 butyrophilin-like 8 2.41067
PABPC4L poly(A) binding protein, cytoplasmic 4-like 2.41067
CLRN1 clarin 1 2.41067
MUC16 mucin 16, cell surface associated 2.41067
KISS1 KiSS-1 metastasis-suppressor 2.41067
CERK ceramide kinase 2.41067
ORM1 orosomucoid 1 2.41067
MYADML2 myeloid-associated differentiation marker-like 2 2.41067
INSL6 insulin-like 6 2.41067
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.41067
LAMB3 laminin, beta 3 2.41067
CCNA1 cyclin A1 2.41067
LRRN4 leucine rich repeat neuronal 4 2.41067
CXORF58 chromosome X open reading frame 58 2.41067
TTC22 tetratricopeptide repeat domain 22 2.41067
LRRC28 leucine rich repeat containing 28 2.41067
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.41067
PLCD4 phospholipase C, delta 4 2.41067
CER1 cerberus 1, DAN family BMP antagonist 2.41067
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.41067
FBXO40 F-box protein 40 2.41067
ZFP92 ZFP92 zinc finger protein 2.41067
KLK3 kallikrein-related peptidase 3 2.41067
FGR FGR proto-oncogene, Src family tyrosine kinase 2.41067
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.41067
ZNF750 zinc finger protein 750 2.41067
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.41067
CTSS cathepsin S 2.41067
GSDMA gasdermin A 2.41067
SCN3B sodium channel, voltage gated, type III beta subunit 2.41067
PRAP1 proline-rich acidic protein 1 2.41067
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 2.41067
MST1R macrophage stimulating 1 receptor 2.41067
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.41067
TMEM86B transmembrane protein 86B 2.41067
C5ORF46 chromosome 5 open reading frame 46 2.41067
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.41067
HIC1 hypermethylated in cancer 1 2.41067
GRAP2 GRB2-related adaptor protein 2 2.41067
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.41067
TGM5 transglutaminase 5 2.41067
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae) 2.41067
AHSG alpha-2-HS-glycoprotein 2.41067
GPR171 G protein-coupled receptor 171 2.41067
MEIOB meiosis specific with OB domains 2.41067
AOC1 amine oxidase, copper containing 1 2.41067
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.41067
ZNF641 zinc finger protein 641 2.41067
DEFB134 defensin, beta 134 2.41067
TGM1 transglutaminase 1 2.41067
DES desmin 2.41067
ABHD17B abhydrolase domain containing 17B 2.41067
SLC10A4 solute carrier family 10, member 4 2.41067
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 2.41067
DMTN dematin actin binding protein 2.41067
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.41067
LEP leptin 2.41067
MIXL1 Mix paired-like homeobox 2.41067
BTBD19 BTB (POZ) domain containing 19 2.41067
PTGDR prostaglandin D2 receptor (DP) 2.41067
ANKRD33 ankyrin repeat domain 33 2.41067
ENDOD1 endonuclease domain containing 1 2.41067
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.41067
MMRN2 multimerin 2 2.41067
CSNK2A2 casein kinase 2, alpha prime polypeptide 2.40907
PCSK5 proprotein convertase subtilisin/kexin type 5 2.38525
PABPN1 poly(A) binding protein, nuclear 1 2.37854
NACAD NAC alpha domain containing 2.37385
CATSPERG catsper channel auxiliary subunit gamma 2.36735
DSC3 desmocollin 3 2.30286
MPDZ multiple PDZ domain protein 2.28869
STAG1 stromal antigen 1 2.27539
CFAP251 cilia and flagella associated protein 251 2.25289
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 2.25048
MYO18A myosin XVIIIA 2.23414
GIP gastric inhibitory polypeptide 2.21849
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 2.21849
PIAS1 protein inhibitor of activated STAT, 1 2.21768
AGO4 argonaute RISC catalytic component 4 2.21768
SKI SKI proto-oncogene 2.20023
RPTOR regulatory associated protein of MTOR, complex 1 2.17765
ALPK3 alpha-kinase 3 2.17703
AKAP17A A kinase (PRKA) anchor protein 17A 2.10533
RHOXF1 Rhox homeobox family, member 1 2.10533
TTC7A tetratricopeptide repeat domain 7A 2.10327
LAMC3 laminin, gamma 3 2.10245
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 2.0983
CADM1 cell adhesion molecule 1 2.0983
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 2.08314
KATNB1 katanin p80 (WD repeat containing) subunit B 1 2.07862
TIPIN TIMELESS interacting protein 2.0694
SDC1 syndecan 1 2.06425
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.04208
ZSWIM3 zinc finger, SWIM-type containing 3 2.01575
KLHL13 kelch-like family member 13 2.00806
ZFPM2 zinc finger protein, FOG family member 2 2.00481
WDR53 WD repeat domain 53 2.00481

decreased expression

Symbol Name Standardized Value
MYOCOS myocilin opposite strand -2.41067
CC2D2A coiled-coil and C2 domain containing 2A -2.41067
BAAT bile acid CoA:amino acid N-acyltransferase -2.41067
CA10 carbonic anhydrase X -2.41067
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -2.41067
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.41067
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.41067
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.41067
RUMY4 RUMY family member 4 -2.41067
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.41067
ATOH7 atonal homolog 7 (Drosophila) -2.41067
TMEM218 transmembrane protein 218 -2.41067
CHD6 chromodomain helicase DNA binding protein 6 -2.41067
OVCH1 ovochymase 1 -2.41067
ZNF878 zinc finger protein 878 -2.41067
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) -2.41067
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.41067
MAST1 microtubule associated serine/threonine kinase 1 -2.41067
PGAP3 post-GPI attachment to proteins 3 -2.41067
SPOCD1 SPOC domain containing 1 -2.41067
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -2.41067
CCN3 cellular communication network factor 3 -2.41067
EFNB1 ephrin-B1 -2.41067
FAM149B1 family with sequence similarity 149, member B1 -2.41067
ACTL6B actin-like 6B -2.41067
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.41067
NOXA1 NADPH oxidase activator 1 -2.41067
SAMD15 sterile alpha motif domain containing 15 -2.41067
ADGRG1 adhesion G protein-coupled receptor G1 -2.41067
AKR1E2 aldo-keto reductase family 1, member E2 -2.41067
NUBP1 nucleotide binding protein 1 -2.41067
BBS5 Bardet-Biedl syndrome 5 -2.41067
SCRG1 stimulator of chondrogenesis 1 -2.41067
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 -2.41067
SPDYE12 speedy/RINGO cell cycle regulator family member E12 -2.41067
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.41067
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.41067
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.41067
MSRB1 methionine sulfoxide reductase B1 -2.41067
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase -2.41067
BAG4 BCL2-associated athanogene 4 -2.41067
OMG oligodendrocyte myelin glycoprotein -2.41067
SVIP small VCP/p97-interacting protein -2.41067
MEIS2 Meis homeobox 2 -2.41067
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.41067
YAF2 YY1 associated factor 2 -2.41067
TMEM102 transmembrane protein 102 -2.41067
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.41067
SPATA18 spermatogenesis associated 18 -2.41067
C11ORF96 chromosome 11 open reading frame 96 -2.41067
GPRIN2 G protein regulated inducer of neurite outgrowth 2 -2.41067
KIF21A kinesin family member 21A -2.41067
NPFFR1 neuropeptide FF receptor 1 -2.41067
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.41067
BAIAP2L2 BAI1-associated protein 2-like 2 -2.41067
MAPK14 mitogen-activated protein kinase 14 -2.41067
CTF1 cardiotrophin 1 -2.41067
PPP1R37 protein phosphatase 1, regulatory subunit 37 -2.41067
C22ORF23 chromosome 22 open reading frame 23 -2.41067
A1CF APOBEC1 complementation factor -2.41067
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha -2.41067
POLM polymerase (DNA directed), mu -2.41067
LRRC38 leucine rich repeat containing 38 -2.41067
PEX11A peroxisomal biogenesis factor 11 alpha -2.41067
GEMIN8 gem (nuclear organelle) associated protein 8 -2.41067
ICAM1 intercellular adhesion molecule 1 -2.41067
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -2.41067
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) -2.37854
FOXO4 forkhead box O4 -2.3543
KIAA1191 KIAA1191 -2.33788
KLRD1 killer cell lectin-like receptor subfamily D, member 1 -2.32933
TOR4A torsin family 4, member A -2.32933
CPNE9 copine family member IX -2.32291
MESD mesoderm development LRP chaperone -2.30371
TMEM127 transmembrane protein 127 -2.21835
TOM1L2 target of myb1-like 2 (chicken) -2.21768
ENG endoglin -2.21768
HARS1 histidyl-tRNA synthetase 1 -2.19006
RNF111 ring finger protein 111 -2.13691
KLC1 kinesin light chain 1 -2.1321
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -2.13101
PKN2 protein kinase N2 -2.11212
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.10245
SPATA6 spermatogenesis associated 6 -2.0983
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -2.09325
TTC1 tetratricopeptide repeat domain 1 -2.07837
SMIM19 small integral membrane protein 19 -2.06953
EIF1 eukaryotic translation initiation factor 1 -2.06723
EXD2 exonuclease 3'-5' domain containing 2 -2.06425
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.05359
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.04209
CCDC142 coiled-coil domain containing 142 -2.04209
ATG9B autophagy related 9B -2.04209
RENBP renin binding protein -2.04209
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -2.04209
ALDOC aldolase C, fructose-bisphosphate -2.03652
LPAR2 lysophosphatidic acid receptor 2 -2.02876
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.0274
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -2.01575
IGSF3 immunoglobulin superfamily, member 3 -2.01312