DAXX Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description death-domain associated protein|This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] (NCBI Entrez Gene Database, 1616)
External Link http://www.ncbi.nlm.nih.gov/gene/1616
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136 interacting proteins for DAXX from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
AIRE autoimmune regulator
AR androgen receptor
ASF1A anti-silencing function 1A histone chaperone
ASF1B anti-silencing function 1B histone chaperone
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRX alpha thalassemia/mental retardation syndrome X-linked
AXIN1 axin 1
BID BH3 interacting domain death agonist
BTBD6 BTB (POZ) domain containing 6
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA12 carbonic anhydrase XII
CALCOCO2 calcium binding and coiled-coil domain 2
CARM1 coactivator-associated arginine methyltransferase 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CHAF1A chromatin assembly factor 1, subunit A (p150)
CREB1 cAMP responsive element binding protein 1
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL3 cullin 3
DAPK3 death-associated protein kinase 3
DBF4 DBF4 zinc finger
DEK DEK proto-oncogene
DMAP1 DNA methyltransferase 1 associated protein 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ESRRG estrogen-related receptor gamma
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADD Fas (TNFRSF6)-associated via death domain
FANCA Fanconi anemia, complementation group A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FKBP14 FK506 binding protein 14, 22 kDa
FTH1 ferritin, heavy polypeptide 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GRK5 G protein-coupled receptor kinase 5
H3F3A H3 histone, family 3A
HABP4 hyaluronan binding protein 4
HAT1 histone acetyltransferase 1
HBA2 hemoglobin, alpha 2
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
HIPK3 homeodomain interacting protein kinase 3
HIRA histone cell cycle regulator
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H3A histone cluster 2, H3a
HSF1 heat shock transcription factor 1
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
KPNA4 karyopherin alpha 4 (importin alpha 3)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAX MYC associated factor X
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCRS1 microspherule protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MST1 macrophage stimulating 1
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NASP nuclear autoantigenic sperm protein (histone-binding)
NBN nibrin
NCF2 neutrophil cytosolic factor 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PARK7 parkinson protein 7
PAX3 paired box 3
PAX5 paired box 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAGL1 pleiomorphic adenoma gene-like 1
PML promyelocytic leukemia
PRMT1 protein arginine methyltransferase 1
RAD50 RAD50 homolog (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RPL13 ribosomal protein L13
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERBP1 SERPINE1 mRNA binding protein 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD4 SMAD family member 4
SNW1 SNW domain containing 1
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPN sialophorin
SPOP speckle-type POZ protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCF3 transcription factor 3
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRAF3 TNF receptor-associated factor 3
TRIM21 tripartite motif containing 21
TRIM27 tripartite motif containing 27
TSG101 tumor susceptibility 101
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2I ubiquitin-conjugating enzyme E2I
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZDHHC17 zinc finger, DHHC-type containing 17