DBT Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description dihydrolipoamide branched chain transacylase E2|The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the branched-chain amino acids isoleucine, leucine, and valine. The BCKD complex is thought to be composed of a core of 24 transacylase (E2) subunits, and associated decarboxylase (E1), dehydrogenase (E3), and regulatory subunits. This gene encodes the transacylase (E2) subunit. Mutations in this gene result in maple syrup urine disease, type 2. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1629)
External Link http://www.ncbi.nlm.nih.gov/gene/1629
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Genes

353 interacting proteins for DBT from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
AASS aminoadipate-semialdehyde synthase
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACAD9 acyl-CoA dehydrogenase family, member 9
ACADVL acyl-CoA dehydrogenase, very long chain
ACOT9 acyl-CoA thioesterase 9
ACTB actin, beta
ADCK3 aarF domain containing kinase 3
ADI1 acireductone dioxygenase 1
AFG3L2 AFG3-like AAA ATPase 2
AGK acylglycerol kinase
AGO2 argonaute RISC catalytic component 2
AGO3 argonaute RISC catalytic component 3
AGO4 argonaute RISC catalytic component 4
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALDH1L2 aldehyde dehydrogenase 1 family, member L2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APC2 adenomatosis polyposis coli 2
APLF aprataxin and PNKP like factor
ARF4 ADP-ribosylation factor 4
ATAD3A ATPase family, AAA domain containing 3A
ATAD3B ATPase family, AAA domain containing 3B
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
C10ORF2 chromosome 10 open reading frame 2
C1QBP complement component 1, q subcomponent binding protein
C6ORF203 chromosome 6 open reading frame 203
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CECR5 cat eye syndrome chromosome region, candidate 5
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9
CLNS1A chloride channel, nucleotide-sensitive, 1A
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COX4I1 cytochrome c oxidase subunit IV isoform 1
CPT2 carnitine palmitoyltransferase 2
DAP3 death associated protein 3
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
ECH1 enoyl CoA hydratase 1, peroxisomal
ECI1 enoyl-CoA delta isomerase 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1G eukaryotic translation elongation factor 1 gamma
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
EMD emerin
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
ERLIN2 ER lipid raft associated 2
ETFA electron-transfer-flavoprotein, alpha polypeptide
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FASTKD1 FAST kinase domains 1
FASTKD2 FAST kinase domains 2
FBL fibrillarin
FLAD1 flavin adenine dinucleotide synthetase 1
FLNA filamin A, alpha
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GALK1 galactokinase 1
GLDC glycine dehydrogenase (decarboxylating)
GLUD1 glutamate dehydrogenase 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRSF1 G-rich RNA sequence binding factor 1
GTPBP10 GTP-binding protein 10 (putative)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIST1H2AB histone cluster 1, H2ab
HIST1H2BL histone cluster 1, H2bl
HK1 hexokinase 1
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPL heterogeneous nuclear ribonucleoprotein L
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICT1 immature colon carcinoma transcript 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
ILF2 interleukin enhancer binding factor 2
IMMT inner membrane protein, mitochondrial
IPO8 importin 8
ISCA1 iron-sulfur cluster assembly 1
JAK1 Janus kinase 1
KARS lysyl-tRNA synthetase
KIAA0391 KIAA0391
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LONP1 lon peptidase 1, mitochondrial
LRPPRC leucine-rich pentatricopeptide repeat containing
MALSU1 mitochondrial assembly of ribosomal large subunit 1
MBL2 mannose-binding lectin (protein C) 2, soluble
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCU mitochondrial calcium uniporter
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
METTL17 methyltransferase like 17
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type
MOGS mannosyl-oligosaccharide glucosidase
MOV10 Mov10 RISC complex RNA helicase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL1 mitochondrial ribosomal protein L1
MRPL10 mitochondrial ribosomal protein L10
MRPL11 mitochondrial ribosomal protein L11
MRPL12 mitochondrial ribosomal protein L12
MRPL13 mitochondrial ribosomal protein L13
MRPL14 mitochondrial ribosomal protein L14
MRPL15 mitochondrial ribosomal protein L15
MRPL16 mitochondrial ribosomal protein L16
MRPL17 mitochondrial ribosomal protein L17
MRPL18 mitochondrial ribosomal protein L18
MRPL19 mitochondrial ribosomal protein L19
MRPL2 mitochondrial ribosomal protein L2
MRPL20 mitochondrial ribosomal protein L20
MRPL21 mitochondrial ribosomal protein L21
MRPL22 mitochondrial ribosomal protein L22
MRPL23 mitochondrial ribosomal protein L23
MRPL24 mitochondrial ribosomal protein L24
MRPL27 mitochondrial ribosomal protein L27
MRPL28 mitochondrial ribosomal protein L28
MRPL3 mitochondrial ribosomal protein L3
MRPL32 mitochondrial ribosomal protein L32
MRPL37 mitochondrial ribosomal protein L37
MRPL38 mitochondrial ribosomal protein L38
MRPL39 mitochondrial ribosomal protein L39
MRPL4 mitochondrial ribosomal protein L4
MRPL40 mitochondrial ribosomal protein L40
MRPL41 mitochondrial ribosomal protein L41
MRPL43 mitochondrial ribosomal protein L43
MRPL44 mitochondrial ribosomal protein L44
MRPL46 mitochondrial ribosomal protein L46
MRPL47 mitochondrial ribosomal protein L47
MRPL48 mitochondrial ribosomal protein L48
MRPL49 mitochondrial ribosomal protein L49
MRPL50 mitochondrial ribosomal protein L50
MRPL51 mitochondrial ribosomal protein L51
MRPL53 mitochondrial ribosomal protein L53
MRPL54 mitochondrial ribosomal protein L54
MRPL55 mitochondrial ribosomal protein L55
MRPL9 mitochondrial ribosomal protein L9
MRPS10 mitochondrial ribosomal protein S10
MRPS11 mitochondrial ribosomal protein S11
MRPS14 mitochondrial ribosomal protein S14
MRPS15 mitochondrial ribosomal protein S15
MRPS16 mitochondrial ribosomal protein S16
MRPS17 mitochondrial ribosomal protein S17
MRPS18A mitochondrial ribosomal protein S18A
MRPS18B mitochondrial ribosomal protein S18B
MRPS2 mitochondrial ribosomal protein S2
MRPS21 mitochondrial ribosomal protein S21
MRPS22 mitochondrial ribosomal protein S22
MRPS23 mitochondrial ribosomal protein S23
MRPS24 mitochondrial ribosomal protein S24
MRPS25 mitochondrial ribosomal protein S25
MRPS26 mitochondrial ribosomal protein S26
MRPS27 mitochondrial ribosomal protein S27
MRPS28 mitochondrial ribosomal protein S28
MRPS30 mitochondrial ribosomal protein S30
MRPS31 mitochondrial ribosomal protein S31
MRPS34 mitochondrial ribosomal protein S34
MRPS35 mitochondrial ribosomal protein S35
MRPS5 mitochondrial ribosomal protein S5
MRPS6 mitochondrial ribosomal protein S6
MRPS7 mitochondrial ribosomal protein S7
MRPS9 mitochondrial ribosomal protein S9
MRRF mitochondrial ribosome recycling factor
MTG1 mitochondrial ribosome-associated GTPase 1
MTIF2 mitochondrial translational initiation factor 2
MTPAP mitochondrial poly(A) polymerase
MUT methylmalonyl CoA mutase
MYCBP MYC binding protein
MYH9 myosin, heavy chain 9, non-muscle
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NGRN neugrin, neurite outgrowth associated
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOA1 nitric oxide associated 1
NONO non-POU domain containing, octamer-binding
NSUN4 NOP2/Sun domain family, member 4
OAT ornithine aminotransferase
OTUD4 OTU deubiquitinase 4
OXA1L oxidase (cytochrome c) assembly 1-like
PABPC1 poly(A) binding protein, cytoplasmic 1
PABPC3 poly(A) binding protein, cytoplasmic 3
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PARK2 parkin RBR E3 ubiquitin protein ligase
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PCCB propionyl CoA carboxylase, beta polypeptide
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PGAM5 phosphoglycerate mutase family member 5
PHB prohibitin
PHB2 prohibitin 2
PMPCA peptidase (mitochondrial processing) alpha
PMPCB peptidase (mitochondrial processing) beta
PNPT1 polyribonucleotide nucleotidyltransferase 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLRMT polymerase (RNA) mitochondrial (DNA directed)
PRDX1 peroxiredoxin 1
PRDX4 peroxiredoxin 4
PRDX5 peroxiredoxin 5
PRMT5 protein arginine methyltransferase 5
PRPF31 pre-mRNA processing factor 31
PSPC1 paraspeckle component 1
PTCD1 pentatricopeptide repeat domain 1
PTCD3 pentatricopeptide repeat domain 3
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTS 6-pyruvoyltetrahydropterin synthase
PUS1 pseudouridylate synthase 1
PUSL1 pseudouridylate synthase-like 1
PXN paxillin
PYCR2 pyrroline-5-carboxylate reductase family, member 2
QPCTL glutaminyl-peptide cyclotransferase-like
RALY RALY heterogeneous nuclear ribonucleoprotein
RALYL RALY RNA binding protein-like
RARS2 arginyl-tRNA synthetase 2, mitochondrial
RBFA ribosome binding factor A (putative)
RBM10 RNA binding motif protein 10
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RIBC2 RIB43A domain with coiled-coils 2
RNMTL1 RNA methyltransferase like 1
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPL23 ribosomal protein L23
RPL24 ribosomal protein L24
RPL27 ribosomal protein L27
RPL27A ribosomal protein L27a
RPL31 ribosomal protein L31
RPL35 ribosomal protein L35
RPL38 ribosomal protein L38
RPL8 ribosomal protein L8
RPLP1 ribosomal protein, large, P1
RPS10P5 ribosomal protein S10 pseudogene 5
RPS11 ribosomal protein S11
RPS12 ribosomal protein S12
RPS18 ribosomal protein S18
RPS23 ribosomal protein S23
RPS24 ribosomal protein S24
RPS25 ribosomal protein S25
RPS26 ribosomal protein S26
RPS29 ribosomal protein S29
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS5 ribosomal protein S5
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
RPS9 ribosomal protein S9
RPUSD3 RNA pseudouridylate synthase domain containing 3
RPUSD4 RNA pseudouridylate synthase domain containing 4
RUVBL2 RuvB-like AAA ATPase 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFXN1 sideroflexin 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A18 solute carrier family 25 (glutamate carrier), member 18
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLIRP SRA stem-loop interacting RNA binding protein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SNRPE small nuclear ribonucleoprotein polypeptide E
SPIN1 spindlin 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRRM2 serine/arginine repetitive matrix 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STK38 serine/threonine kinase 38
STOML2 stomatin (EPB72)-like 2
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SUN2 Sad1 and UNC84 domain containing 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TEFM transcription elongation factor, mitochondrial
TFAM transcription factor A, mitochondrial
TFB1M transcription factor B1, mitochondrial
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast)
TMLHE trimethyllysine hydroxylase, epsilon
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNRC6A trinucleotide repeat containing 6A
TNRC6B trinucleotide repeat containing 6B
TOP1 topoisomerase (DNA) I
TRIM21 tripartite motif containing 21
TRMT10C tRNA methyltransferase 10 homolog C (S. cerevisiae)
TRUB2 TruB pseudouridine (psi) synthase family member 2
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUFM Tu translation elongation factor, mitochondrial
UBC ubiquitin C
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP16 ubiquitin specific peptidase 16
VARS2 valyl-tRNA synthetase 2, mitochondrial
VDAC1 voltage-dependent anion channel 1
VDAC3 voltage-dependent anion channel 3
WBSCR16 Williams-Beuren syndrome chromosome region 16
WDR77 WD repeat domain 77
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
YBX1 Y box binding protein 1
YME1L1 YME1-like 1 ATPase