DC-05-LU10_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, (S)-3-{[1-(2-Fluoro-Phenyl)-5-Hydroxy-1h-Pyrazole-3-Carbonyl]-Amino}-3-O-Tolyl-Propionic Acid targeting CTSA (Novartis, 60182322)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/60182322
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Genes

222 genes differentially expressed following the DC-05-LU10_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RPS5 ribosomal protein S5 0.447589
RPL18A ribosomal protein L18a 0.447589
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.435156
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.420424
RPS14 ribosomal protein S14 0.389697
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.38662
RPL18 ribosomal protein L18 0.380811
LGALS1 lectin, galactoside-binding, soluble, 1 0.357171
MZT2B mitotic spindle organizing protein 2B 0.357171
HMGA1 high mobility group AT-hook 1 0.357171
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.353027
RPL37A ribosomal protein L37a 0.340352
C19ORF33 chromosome 19 open reading frame 33 0.331266
RPL8 ribosomal protein L8 0.330165
METTL26 methyltransferase like 26 0.330057
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.319745
CST3 cystatin C 0.316897
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.314732
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.314732
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.312787
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.305301
ATP5F1D ATP synthase F1 subunit delta 0.304922
KRT17 keratin 17, type I 0.304824
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 0.304092
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.301685
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.299553
MRPL12 mitochondrial ribosomal protein L12 0.298026
PHPT1 phosphohistidine phosphatase 1 0.294263
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.291198
ZNF358 zinc finger protein 358 0.288683
PTOV1 prostate tumor overexpressed 1 0.288112
RPS3 ribosomal protein S3 0.286884
OAZ1 ornithine decarboxylase antizyme 1 0.285719
LMNA lamin A/C 0.283461
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.278336
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.277307
NINJ1 ninjurin 1 0.276105
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.272396
FES FES proto-oncogene, tyrosine kinase 0.272253
PITX1 paired-like homeodomain 1 0.268922
RPS15 ribosomal protein S15 0.263282
MZT2A mitotic spindle organizing protein 2A 0.262781
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.259073
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 0.259073
GPX1 glutathione peroxidase 1 0.25603
LY6E lymphocyte antigen 6 complex, locus E 0.254366
RPL28 ribosomal protein L28 0.253711
HSPB1 heat shock 27kDa protein 1 0.253478
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.252548
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.250419
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.249357
CD81 CD81 molecule 0.249357
RPL36 ribosomal protein L36 0.249175
MCRIP1 MAPK regulated corepressor interacting protein 1 0.247205
RABAC1 Rab acceptor 1 (prenylated) 0.245393
CCDC85B coiled-coil domain containing 85B 0.241738
RPS19 ribosomal protein S19 0.237309
TAGLN transgelin 0.237309
GUK1 guanylate kinase 1 0.23699
TMEM132A transmembrane protein 132A 0.234665
TMEM205 transmembrane protein 205 0.234665
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 0.234665
SCAND1 SCAN domain containing 1 0.234665
TBC1D22A TBC1 domain family, member 22A 0.233844
RNASEH1 ribonuclease H1 0.232281
UBB ubiquitin B 0.231362
PPIE peptidylprolyl isomerase E (cyclophilin E) 0.231362
GALE UDP-galactose-4-epimerase 0.22929
C12ORF57 chromosome 12 open reading frame 57 0.228975
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.22792
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.226087
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 0.224527
MAP7D1 MAP7 domain containing 1 0.224527
BCL7C B-cell CLL/lymphoma 7C 0.224454
CENPM centromere protein M 0.224219
CIB1 calcium and integrin binding 1 (calmyrin) 0.223554
MAN2B1 mannosidase, alpha, class 2B, member 1 0.219403
GALK1 galactokinase 1 0.215117
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.213394
EGFL7 EGF-like-domain, multiple 7 0.213004
FAM174C family with sequence similarity 174 member C 0.213004
TBRG4 transforming growth factor beta regulator 4 0.212332
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.212146
MYL9 myosin, light chain 9, regulatory 0.211255
DGCR6L DiGeorge syndrome critical region gene 6-like 0.211143
MYDGF myeloid-derived growth factor 0.210795
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.20771
VEGFB vascular endothelial growth factor B 0.207504
CAPNS1 calpain, small subunit 1 0.206904
FSCN1 fascin actin-bundling protein 1 0.205428
CISD3 CDGSH iron sulfur domain 3 0.204826
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.203704
MRPS25 mitochondrial ribosomal protein S25 0.20238
TFDP1 transcription factor Dp-1 0.200901

decreased expression

Symbol Name Standardized Value
ZNF7 zinc finger protein 7 -0.688611
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.577212
VIM vimentin -0.447589
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.447589
ZFP36L1 ZFP36 ring finger protein-like 1 -0.435156
MRPL15 mitochondrial ribosomal protein L15 -0.435156
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.435156
PPA1 pyrophosphatase (inorganic) 1 -0.430984
ZBTB25 zinc finger and BTB domain containing 25 -0.429355
NOL11 nucleolar protein 11 -0.410865
LDHB lactate dehydrogenase B -0.389697
FKBP1A FK506 binding protein 1A, 12kDa -0.383122
VMP1 vacuole membrane protein 1 -0.380811
RPS13 ribosomal protein S13 -0.368944
B2M beta-2-microglobulin -0.357171
RAB9A RAB9A, member RAS oncogene family -0.357171
RPL9 ribosomal protein L9 -0.356279
NKTR natural killer cell triggering receptor -0.353584
SBDS Shwachman-Bodian-Diamond syndrome -0.340352
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.340352
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.331624
AZIN2 antizyme inhibitor 2 -0.330057
TMEM50B transmembrane protein 50B -0.330057
SRSF2 serine/arginine-rich splicing factor 2 -0.330057
RAB2B RAB2B, member RAS oncogene family -0.329265
THRAP3 thyroid hormone receptor associated protein 3 -0.328306
CTSV cathepsin V -0.324514
MT1E metallothionein 1E -0.314732
EIF3E eukaryotic translation initiation factor 3, subunit E -0.314732
DHFR dihydrofolate reductase -0.314732
BEST1 bestrophin 1 -0.314732
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.314732
EIF4E eukaryotic translation initiation factor 4E -0.305301
PGK1 phosphoglycerate kinase 1 -0.305301
TRAF5 TNF receptor-associated factor 5 -0.304824
SRGAP2C SLIT-ROBO Rho GTPase activating protein 2C -0.304824
CAND1 cullin-associated and neddylation-dissociated 1 -0.289174
PBK PDZ binding kinase -0.289174
MRE11 MRE11 homolog, double strand break repair nuclease -0.28661
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.285719
BRD7 bromodomain containing 7 -0.283637
RPL23 ribosomal protein L23 -0.283364
RNF38 ring finger protein 38 -0.283046
ATP5PB ATP synthase peripheral stalk-membrane subunit b -0.277307
LRRC37B leucine rich repeat containing 37B -0.276953
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.270359
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase -0.270359
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -0.269909
C11ORF58 chromosome 11 open reading frame 58 -0.268922
C2ORF42 chromosome 2 open reading frame 42 -0.264486
EDN1 endothelin 1 -0.263123
SEC23A Sec23 homolog A (S. cerevisiae) -0.262781
TXNDC17 thioredoxin domain containing 17 -0.262036
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.256706
RPS27A ribosomal protein S27a -0.256442
RPP40 ribonuclease P/MRP 40kDa subunit -0.256442
PFN2 profilin 2 -0.256318
MORF4L1 mortality factor 4 like 1 -0.255615
SPTSSA serine palmitoyltransferase, small subunit A -0.251515
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -0.251515
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -0.251515
RPS20 ribosomal protein S20 -0.251242
TM9SF2 transmembrane 9 superfamily member 2 -0.249736
ATP5PO ATP synthase peripheral stalk subunit OSCP -0.245494
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.245393
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -0.244665
RPS3A ribosomal protein S3A -0.24443
ZNF266 zinc finger protein 266 -0.238735
SSBP1 single-stranded DNA binding protein 1, mitochondrial -0.238495
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.238191
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -0.236604
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.236604
TMEM41B transmembrane protein 41B -0.235489
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.235489
CENPW centromere protein W -0.235489
NFE2L2 nuclear factor, erythroid 2-like 2 -0.234033
SLC38A2 solute carrier family 38, member 2 -0.233561
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.232516
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 -0.231876
UBASH3B ubiquitin associated and SH3 domain containing B -0.231692
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -0.231362
RRM2 ribonucleotide reductase M2 -0.231362
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -0.231362
PRDX4 peroxiredoxin 4 -0.231362
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.231362
C12ORF75 chromosome 12 open reading frame 75 -0.231362
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.231362
TMEM263 transmembrane protein 263 -0.230434
COX7C cytochrome c oxidase subunit VIIc -0.22929
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.226575
OXSR1 oxidative stress responsive 1 -0.225788
RPL4 ribosomal protein L4 -0.225428
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.224687
RPL23A ribosomal protein L23a -0.222819
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 -0.222465
CCNI cyclin I -0.222149
SRSF10 serine/arginine-rich splicing factor 10 -0.221861
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.218146
DYNLL1 dynein, light chain, LC8-type 1 -0.21807
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -0.216618
QSER1 glutamine and serine rich 1 -0.215117
HSPA12A heat shock 70kDa protein 12A -0.215117
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -0.214376
MOB4 MOB family member 4, phocein -0.214376
FTH1 ferritin, heavy polypeptide 1 -0.213781
RTRAF RNA transcription, translation and transport factor -0.213394
RAN RAN, member RAS oncogene family -0.213004
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.212332
CCNB2 cyclin B2 -0.212332
GRSF1 G-rich RNA sequence binding factor 1 -0.212056
CUL4B cullin 4B -0.211703
RFK riboflavin kinase -0.211104
FLCN folliculin -0.20918
ARID5B AT rich interactive domain 5B (MRF1-like) -0.209099
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.2088
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) -0.207297
RPL26 ribosomal protein L26 -0.206629
RPS24 ribosomal protein S24 -0.206629
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -0.206629
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.204826
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.204826
ENAH enabled homolog (Drosophila) -0.204715
NUP155 nucleoporin 155kDa -0.203748
LYRM7 LYR motif containing 7 -0.203704
SKP1 S-phase kinase-associated protein 1 -0.203268
SH3BGRL SH3 domain binding glutamate-rich protein like -0.200932
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.200269
ARF4 ADP-ribosylation factor 4 -0.200269