DC-05-LU10_0.1uM Gene Set

Dataset	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category	transcriptomics
Type	drug perturbation
Description	Dose=0.1uM, (S)-3-{[1-(2-Fluoro-Phenyl)-5-Hydroxy-1h-Pyrazole-3-Carbonyl]-Amino}-3-O-Tolyl-Propionic Acid targeting CTSA (Novartis, 60182322)
External Link	https://pubchem.ncbi.nlm.nih.gov/compound/60182322
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Genes

8 genes differentially expressed following the DC-05-LU10_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol	Name	Standardized Value
NDUFB7	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa	0.260904
LSM7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	0.233289
TIMP1	TIMP metallopeptidase inhibitor 1	0.213131
TIMM17B	translocase of inner mitochondrial membrane 17 homolog B (yeast)	0.212351
TAGLN	transgelin	0.204014
ELOB	elongin B	0.204014

decreased expression

Symbol	Name	Standardized Value
SNRNP35	small nuclear ribonucleoprotein 35kDa (U11/U12)	-0.218062
PPP1R14C	protein phosphatase 1, regulatory (inhibitor) subunit 14C	-0.213131