DC-17-EL33_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, 10-Methoxy-2,2,4-trimethyl-5-prop-2-enyl-1,5-dihydrochromeno[3,4-f]quinoline, Glucocorticoid Receptor (GR) Modulators targeting NR3C1 (Novartis, 9906282)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9906282
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Genes

14 genes differentially expressed following the DC-17-EL33_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.06856
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.534415
DAD1 defender against cell death 1 0.333505
KRT14 keratin 14, type I 0.230097
GNG5 guanine nucleotide binding protein (G protein), gamma 5 0.22528
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.22528
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.22528
RPL27A ribosomal protein L27a 0.219048

decreased expression

Symbol Name Standardized Value
REST RE1-silencing transcription factor -0.368408
C1QBP complement component 1, q subcomponent binding protein -0.355558
LRRC37B leucine rich repeat containing 37B -0.355558
CNN3 calponin 3, acidic -0.27373
RPS4X ribosomal protein S4, X-linked -0.249004
LTA4H leukotriene A4 hydrolase -0.22528