DC-17-EL33_10uM Gene Set

Dataset	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category	transcriptomics
Type	drug perturbation
Description	Dose=10uM, 10-Methoxy-2,2,4-trimethyl-5-prop-2-enyl-1,5-dihydrochromeno[3,4-f]quinoline, Glucocorticoid Receptor (GR) Modulators targeting NR3C1 (Novartis, 9906282)
External Link	https://pubchem.ncbi.nlm.nih.gov/compound/9906282
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Genes

8 genes differentially expressed following the DC-17-EL33_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol	Name	Standardized Value
MYL2	myosin, light chain 2, regulatory, cardiac, slow	0.830512
MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.237888
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.23658
MORF4L2	mortality factor 4 like 2	0.212447

decreased expression

Symbol	Name	Standardized Value
GPBP1	GC-rich promoter binding protein 1	-0.327669
MAGED1	melanoma antigen family D1	-0.308568
UBR7	ubiquitin protein ligase E3 component n-recognin 7 (putative)	-0.271792
TP53RK	TP53 regulating kinase	-0.21378