DC-50-QD52_0.01uM Gene Set
| Dataset |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
|
| Category |
transcriptomics
|
| Type |
drug perturbation |
| Description |
Dose=0.01uM, Cts-1027, MMP-14 (Membrane-Type Matrix Metalloproteinase 1) Inhibitors;MMP-12 (Macrophage Elastase) Inhibitors;MMP-13 (Collagenase 3) Inhibitors;MMP-9 (Gelatinase B) Inhibitors;MMP-3 (Stromelysin 1) Inhibitors;MMP-8 (Neutrophil Collagenase) Inhibitors;MMP-2 (Gelatinase A) Inhibitors targeting MMP14, MMP11, MMP15, MMP16, MMP17, MMP19, MMP23A, MMP20, MMP27, MMP28, MMP21 (Novartis, 3342298)
|
| External Link |
https://pubchem.ncbi.nlm.nih.gov/compound/3342298
|
| Similar Terms |
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| Downloads & Tools |
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Genes
16 genes differentially expressed following the DC-50-QD52_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
MMP28
|
matrix metallopeptidase 28
|
0.385058
|
|
NDUFA11
|
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
|
0.357498
|
|
RPS15
|
ribosomal protein S15
|
0.297375
|
|
BLVRB
|
biliverdin reductase B
|
0.214882
|
|
KPNA5
|
karyopherin alpha 5 (importin alpha 6)
|
0.212394
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
HNRNPD
|
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
|
-0.392731
|
|
POLR1B
|
polymerase (RNA) I polypeptide B, 128kDa
|
-0.392731
|
|
KDM4B
|
lysine (K)-specific demethylase 4B
|
-0.359655
|
|
GRPEL1
|
GrpE-like 1, mitochondrial (E. coli)
|
-0.342357
|
|
SND1
|
staphylococcal nuclease and tudor domain containing 1
|
-0.273102
|
|
ATP6AP1
|
ATPase, H+ transporting, lysosomal accessory protein 1
|
-0.273102
|
|
RAB5IF
|
RAB5 interacting factor
|
-0.214882
|
|
DHRS2
|
dehydrogenase/reductase (SDR family) member 2
|
-0.214882
|
|
PITPNA
|
phosphatidylinositol transfer protein, alpha
|
-0.212183
|
|
COPA
|
coatomer protein complex, subunit alpha
|
-0.207625
|
|
USF2
|
upstream transcription factor 2, c-fos interacting
|
-0.207625
|
