DC-50-QD52_10uM Gene Set
| Dataset |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
|
| Category |
transcriptomics
|
| Type |
drug perturbation |
| Description |
Dose=10uM, Cts-1027, MMP-14 (Membrane-Type Matrix Metalloproteinase 1) Inhibitors;MMP-12 (Macrophage Elastase) Inhibitors;MMP-13 (Collagenase 3) Inhibitors;MMP-9 (Gelatinase B) Inhibitors;MMP-3 (Stromelysin 1) Inhibitors;MMP-8 (Neutrophil Collagenase) Inhibitors;MMP-2 (Gelatinase A) Inhibitors targeting MMP14, MMP11, MMP15, MMP16, MMP17, MMP19, MMP23A, MMP20, MMP27, MMP28, MMP21 (Novartis, 3342298)
|
| External Link |
https://pubchem.ncbi.nlm.nih.gov/compound/3342298
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| Similar Terms |
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| Downloads & Tools |
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Genes
9 genes differentially expressed following the DC-50-QD52_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
CCT7
|
chaperonin containing TCP1, subunit 7 (eta)
|
0.625564
|
|
DDIT4
|
DNA-damage-inducible transcript 4
|
0.406584
|
|
SF3B6
|
splicing factor 3b, subunit 6, 14kDa
|
0.339569
|
|
ABHD14B
|
abhydrolase domain containing 14B
|
0.255142
|
|
NDUFS4
|
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
|
0.2448
|
|
RNF138
|
ring finger protein 138, E3 ubiquitin protein ligase
|
0.214678
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
PITHD1
|
PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
|
-0.276942
|
|
CPSF6
|
cleavage and polyadenylation specific factor 6, 68kDa
|
-0.255142
|
|
RBM39
|
RNA binding motif protein 39
|
-0.202032
|
