DC-50-QD52_1uM Gene Set
| Dataset |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
|
| Category |
transcriptomics
|
| Type |
drug perturbation |
| Description |
Dose=1uM, Cts-1027, MMP-14 (Membrane-Type Matrix Metalloproteinase 1) Inhibitors;MMP-12 (Macrophage Elastase) Inhibitors;MMP-13 (Collagenase 3) Inhibitors;MMP-9 (Gelatinase B) Inhibitors;MMP-3 (Stromelysin 1) Inhibitors;MMP-8 (Neutrophil Collagenase) Inhibitors;MMP-2 (Gelatinase A) Inhibitors targeting MMP14, MMP11, MMP15, MMP16, MMP17, MMP19, MMP23A, MMP20, MMP27, MMP28, MMP21 (Novartis, 3342298)
|
| External Link |
https://pubchem.ncbi.nlm.nih.gov/compound/3342298
|
| Similar Terms |
|
| Downloads & Tools |
|
Genes
31 genes differentially expressed following the DC-50-QD52_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
CCT7
|
chaperonin containing TCP1, subunit 7 (eta)
|
0.4551
|
|
POLR2L
|
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
|
0.352518
|
|
PHPT1
|
phosphohistidine phosphatase 1
|
0.284163
|
|
KRT17
|
keratin 17, type I
|
0.250326
|
|
RPS15
|
ribosomal protein S15
|
0.250326
|
|
ABHD14B
|
abhydrolase domain containing 14B
|
0.22424
|
|
RPL35
|
ribosomal protein L35
|
0.204147
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
FUBP1
|
far upstream element (FUSE) binding protein 1
|
-0.4551
|
|
DNAJC7
|
DnaJ (Hsp40) homolog, subfamily C, member 7
|
-0.426936
|
|
RBBP6
|
retinoblastoma binding protein 6
|
-0.411027
|
|
MAP3K7
|
mitogen-activated protein kinase kinase kinase 7
|
-0.348176
|
|
REEP4
|
receptor accessory protein 4
|
-0.316084
|
|
DBF4
|
DBF4 zinc finger
|
-0.308544
|
|
RAP1A
|
RAP1A, member of RAS oncogene family
|
-0.308544
|
|
RARG
|
retinoic acid receptor, gamma
|
-0.284163
|
|
DZIP1
|
DAZ interacting zinc finger protein 1
|
-0.281187
|
|
CMIP
|
c-Maf inducing protein
|
-0.281187
|
|
ITPRIP
|
inositol 1,4,5-trisphosphate receptor interacting protein
|
-0.268617
|
|
MGME1
|
mitochondrial genome maintenance exonuclease 1
|
-0.267204
|
|
MFSD5
|
major facilitator superfamily domain containing 5
|
-0.260627
|
|
EP300
|
E1A binding protein p300
|
-0.257568
|
|
BORCS6
|
BLOC-1 related complex subunit 6
|
-0.248761
|
|
CENPU
|
centromere protein U
|
-0.247068
|
|
YBX3
|
Y box binding protein 3
|
-0.247068
|
|
VLDLR
|
very low density lipoprotein receptor
|
-0.239972
|
|
PER1
|
period circadian clock 1
|
-0.222657
|
|
AKAP9
|
A kinase (PRKA) anchor protein 9
|
-0.222657
|
|
SIRAL2
|
SIR2 antiphage like 2
|
-0.215777
|
|
SEC16A
|
SEC16 homolog A (S. cerevisiae)
|
-0.211069
|
|
MMADHC
|
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
|
-0.206049
|
|
TIGD6
|
tigger transposable element derived 6
|
-0.206049
|
