DC-59-NQ20_0.01uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.01uM, Vx-702, P38a kinase inhibitor targeting MAPK14 (Novartis, 10341154)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10341154
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Genes

209 genes differentially expressed following the DC-59-NQ20_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
CCT7 chaperonin containing TCP1, subunit 7 (eta) 1.70026
RPL37A ribosomal protein L37a 1.26043
UBB ubiquitin B 0.959004
RPS21 ribosomal protein S21 0.813811
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.813811
RPS15 ribosomal protein S15 0.79513
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.754373
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.743446
C19ORF33 chromosome 19 open reading frame 33 0.737447
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.708396
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.701071
KRT17 keratin 17, type I 0.679533
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.679533
TBCB tubulin folding cofactor B 0.679533
RPLP2 ribosomal protein, large, P2 0.67817
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.662683
RPL38 ribosomal protein L38 0.662683
ROMO1 reactive oxygen species modulator 1 0.648744
ATOX1 antioxidant 1 copper chaperone 0.64625
SEM1 SEM1 26S proteasome subunit 0.628959
RPS29 ribosomal protein S29 0.623494
RPS5 ribosomal protein S5 0.600548
RPL18 ribosomal protein L18 0.593793
TAGLN transgelin 0.566666
SF3B5 splicing factor 3b, subunit 5, 10kDa 0.558266
TMEM109 transmembrane protein 109 0.55396
RPS27 ribosomal protein S27 0.529899
HSPB1 heat shock 27kDa protein 1 0.520296
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.520296
CST3 cystatin C 0.51994
TMEM9 transmembrane protein 9 0.508933
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 0.508868
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.49251
TIMP1 TIMP metallopeptidase inhibitor 1 0.482449
TPM2 tropomyosin 2 (beta) 0.470275
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.461053
RPS3 ribosomal protein S3 0.461053
MVP major vault protein 0.461053
RPL8 ribosomal protein L8 0.455457
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.45253
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.43961
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.438346
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.428926
PHPT1 phosphohistidine phosphatase 1 0.424859
RPL41 ribosomal protein L41 0.423375
LGALS1 lectin, galactoside-binding, soluble, 1 0.421299
MYDGF myeloid-derived growth factor 0.417976
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.415708
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.406347
SCAND1 SCAN domain containing 1 0.405946
LOC112694756 uncharaterized LOC112694756 0.405946
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 0.402843
TMEM256 transmembrane protein 256 0.402171
LMNA lamin A/C 0.396938
FOXP1 forkhead box P1 0.391355
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.383402
RPL35A ribosomal protein L35a 0.381628
MED10 mediator complex subunit 10 0.381628
GALE UDP-galactose-4-epimerase 0.381628
GAMT guanidinoacetate N-methyltransferase 0.381628
HDGF hepatoma-derived growth factor 0.376945
COMMD4 COMM domain containing 4 0.37522
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.37522
ASL argininosuccinate lyase 0.37522
EIF6 eukaryotic translation initiation factor 6 0.375018
C12ORF57 chromosome 12 open reading frame 57 0.373661
CLU clusterin 0.367999
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.363046
TUFM Tu translation elongation factor, mitochondrial 0.361316
RPS15A ribosomal protein S15a 0.35826
MTLN mitoregulin 0.341421
HMGA1 high mobility group AT-hook 1 0.341421
RPL28 ribosomal protein L28 0.338869
PHGDH phosphoglycerate dehydrogenase 0.337914
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.333167
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.333101
MRPL14 mitochondrial ribosomal protein L14 0.332037
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 0.328255
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.328017
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.327608
GSDMD gasdermin D 0.327331
GALK1 galactokinase 1 0.326017
TMEM205 transmembrane protein 205 0.313251
RABAC1 Rab acceptor 1 (prenylated) 0.312565
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.310831
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.310327
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.302747
TECR trans-2,3-enoyl-CoA reductase 0.30072
TNNI3 troponin I type 3 (cardiac) 0.299675
NF2 neurofibromin 2 (merlin) 0.298069
MZT2B mitotic spindle organizing protein 2B 0.295213
RPL36 ribosomal protein L36 0.290062
C1D C1D nuclear receptor corepressor 0.289115
ARL2 ADP-ribosylation factor-like 2 0.284113
RPS9 ribosomal protein S9 0.278187
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 0.278187
RPS14 ribosomal protein S14 0.276178
UBL5 ubiquitin-like 5 0.275174
CISD3 CDGSH iron sulfur domain 3 0.273147
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.27222
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 0.269513
PTGES2 prostaglandin E synthase 2 0.266979
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.265208
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.26506
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.264686
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.258675
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.25635
NHP2 NHP2 ribonucleoprotein 0.253238
YDJC YdjC homolog (bacterial) 0.252028
CLIC1 chloride intracellular channel 1 0.24925
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.248938
MRPL36 mitochondrial ribosomal protein L36 0.246047
CCNI cyclin I 0.242062
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.238942
C19ORF81 chromosome 19 open reading frame 81 0.238942
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.236729
UBA1 ubiquitin-like modifier activating enzyme 1 0.234473
MLF2 myeloid leukemia factor 2 0.23104
RPL18A ribosomal protein L18a 0.229642
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.229642
RPL39 ribosomal protein L39 0.228709
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 0.227917
EDF1 endothelial differentiation-related factor 1 0.225923
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 0.219867
RPLP1 ribosomal protein, large, P1 0.219268
CDC37 cell division cycle 37 0.217992
COX5B cytochrome c oxidase subunit Vb 0.215967
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.215844
PPP4C protein phosphatase 4, catalytic subunit 0.215458
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.213101
CENPM centromere protein M 0.210895
OBSL1 obscurin-like 1 0.210878
S100A6 S100 calcium binding protein A6 0.210868
FES FES proto-oncogene, tyrosine kinase 0.210868
BSG basigin (Ok blood group) 0.209547
FDXR ferredoxin reductase 0.209547
CALR calreticulin 0.209547
MRPL52 mitochondrial ribosomal protein L52 0.209437
PTOV1 prostate tumor overexpressed 1 0.209437
SCYL1 SCY1-like 1 (S. cerevisiae) 0.208243
ACD adrenocortical dysplasia homolog (mouse) 0.206009
KEAP1 kelch-like ECH-associated protein 1 0.203722
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 0.202827
NCSTN nicastrin 0.202004
DMAC1 distal membrane arm assembly component 1 0.20184
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.20184
MZT2A mitotic spindle organizing protein 2A 0.20184
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.20184
GPAA1 glycosylphosphatidylinositol anchor attachment 1 0.20184
KISS1 KiSS-1 metastasis-suppressor 0.20184
MFAP2 microfibrillar-associated protein 2 0.200774
TRIP6 thyroid hormone receptor interactor 6 0.200066
ZNHIT1 zinc finger, HIT-type containing 1 0.200066
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.200066

decreased expression

Symbol Name Standardized Value
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted -0.544512
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.502567
TCAIM T cell activation inhibitor, mitochondrial -0.486841
YBX3 Y box binding protein 3 -0.464324
SCPEP1 serine carboxypeptidase 1 -0.455457
LRRC37B leucine rich repeat containing 37B -0.451431
TLNRD1 talin rod domain containing 1 -0.43961
TPT1 tumor protein, translationally-controlled 1 -0.423135
RXYLT1 ribitol xylosyltransferase 1 -0.403306
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -0.394557
CEP70 centrosomal protein 70kDa -0.341631
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.341421
CAV1 caveolin 1, caveolae protein, 22kDa -0.339081
RPS8 ribosomal protein S8 -0.337914
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.328885
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.327595
BICD1 bicaudal D homolog 1 (Drosophila) -0.322
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.320007
FTH1 ferritin, heavy polypeptide 1 -0.316698
PRCC papillary renal cell carcinoma (translocation-associated) -0.307069
YBX1 Y box binding protein 1 -0.303564
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -0.294063
MRGBP MRG/MORF4L binding protein -0.293788
EIF1 eukaryotic translation initiation factor 1 -0.293659
EID1 EP300 interacting inhibitor of differentiation 1 -0.2846
RTRAF RNA transcription, translation and transport factor -0.277471
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.269368
MASTL microtubule associated serine/threonine kinase-like -0.263611
TMSB4X thymosin beta 4, X-linked -0.252028
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.250774
WBP11 WW domain binding protein 11 -0.248938
NSD3 nuclear receptor binding SET domain protein 3 -0.238316
RAB5IF RAB5 interacting factor -0.229642
C12ORF75 chromosome 12 open reading frame 75 -0.229126
EI24 etoposide induced 2.4 -0.227917
RTL8A retrotransposon Gag like 8A -0.227917
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.226349
RPL6 ribosomal protein L6 -0.219268
ARL2BP ADP-ribosylation factor-like 2 binding protein -0.219268
EXOSC3 exosome component 3 -0.213823
TARDBP TAR DNA binding protein -0.213572
DENND1A DENN/MADD domain containing 1A -0.210868
MAP3K7CL MAP3K7 C-terminal like -0.210868
VTI1B vesicle transport through interaction with t-SNAREs 1B -0.210868
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.20984
ATXN2 ataxin 2 -0.209376
RPS6 ribosomal protein S6 -0.208785
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -0.208214
GLRX5 glutaredoxin 5 -0.208001
MOGAT2 monoacylglycerol O-acyltransferase 2 -0.20184
MAGEA1 melanoma antigen family A1 -0.20184
STK17A serine/threonine kinase 17a -0.20184
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.201606
MAPK9 mitogen-activated protein kinase 9 -0.200696
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.200066