DC-59-NQ20_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, Vx-702, P38a kinase inhibitor targeting MAPK14 (Novartis, 10341154)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10341154
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Genes

240 genes differentially expressed following the DC-59-NQ20_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 2.24602
RPL37A ribosomal protein L37a 1.92122
RPS15 ribosomal protein S15 1.86752
RPS14 ribosomal protein S14 1.64053
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 1.54676
RPS27 ribosomal protein S27 1.493
ROMO1 reactive oxygen species modulator 1 1.47228
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 1.42649
UBC ubiquitin C 1.3518
TAGLN transgelin 1.27982
RPL38 ribosomal protein L38 1.26548
CCT7 chaperonin containing TCP1, subunit 7 (eta) 1.12954
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 1.02514
MLF2 myeloid leukemia factor 2 1.00444
ATOX1 antioxidant 1 copper chaperone 0.923407
RPLP2 ribosomal protein, large, P2 0.918827
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.913416
GSTP1 glutathione S-transferase pi 1 0.905599
RPS5 ribosomal protein S5 0.846174
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.840367
LGALS1 lectin, galactoside-binding, soluble, 1 0.840367
RPL18 ribosomal protein L18 0.805602
BLVRB biliverdin reductase B 0.799337
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.794051
TIMP1 TIMP metallopeptidase inhibitor 1 0.767505
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.757322
HDGF hepatoma-derived growth factor 0.748526
MICALL1 MICAL-like 1 0.699436
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.691848
KRT17 keratin 17, type I 0.667218
RPS29 ribosomal protein S29 0.655186
COX5B cytochrome c oxidase subunit Vb 0.650737
RPL35A ribosomal protein L35a 0.642231
SSR4 signal sequence receptor, delta 0.632711
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.616628
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.606955
ZNRD2 zinc ribbon domain containing 2 0.601263
RPS3 ribosomal protein S3 0.601263
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.601118
GALM galactose mutarotase (aldose 1-epimerase) 0.598977
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.584553
RPL28 ribosomal protein L28 0.558975
MT1E metallothionein 1E 0.554165
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.552229
MRPL13 mitochondrial ribosomal protein L13 0.539862
YDJC YdjC homolog (bacterial) 0.521997
RUVBL2 RuvB-like AAA ATPase 2 0.512777
S100A6 S100 calcium binding protein A6 0.506115
HSPB1 heat shock 27kDa protein 1 0.492517
MVP major vault protein 0.49148
RPL18A ribosomal protein L18a 0.488752
MYL12B myosin, light chain 12B, regulatory 0.487317
NF2 neurofibromin 2 (merlin) 0.474896
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.472492
TAGLN2 transgelin 2 0.464664
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.463284
C19ORF33 chromosome 19 open reading frame 33 0.448589
IPO4 importin 4 0.417008
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.410482
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.409163
TRAP1 TNF receptor-associated protein 1 0.407678
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.402907
P4HB prolyl 4-hydroxylase, beta polypeptide 0.396737
RNF181 ring finger protein 181 0.38343
TMEM160 transmembrane protein 160 0.38343
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.377995
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.376927
GDI1 GDP dissociation inhibitor 1 0.376927
METRN meteorin, glial cell differentiation regulator 0.373994
RPL31 ribosomal protein L31 0.371626
TMEM9 transmembrane protein 9 0.371341
RPS16 ribosomal protein S16 0.368841
C12ORF57 chromosome 12 open reading frame 57 0.364636
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.358445
PTGES2 prostaglandin E synthase 2 0.345704
GSDMD gasdermin D 0.338471
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.334224
MTLN mitoregulin 0.333367
MICALL2 MICAL-like 2 0.332996
CHURC1-FNTB CHURC1-FNTB readthrough 0.330582
HSPA8 heat shock 70kDa protein 8 0.327321
TBCB tubulin folding cofactor B 0.323388
MZT2B mitotic spindle organizing protein 2B 0.320796
CCNB1 cyclin B1 0.317845
EIF6 eukaryotic translation initiation factor 6 0.317627
MRPL52 mitochondrial ribosomal protein L52 0.314049
RUNX1 runt-related transcription factor 1 0.312059
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.309607
PCSK7 proprotein convertase subtilisin/kexin type 7 0.308419
RPS7 ribosomal protein S7 0.306033
OLFML3 olfactomedin-like 3 0.304277
PYCR1 pyrroline-5-carboxylate reductase 1 0.302677
MRPL40 mitochondrial ribosomal protein L40 0.302062
RPL41 ribosomal protein L41 0.297368
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.288452
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.288188
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.28361
TPM2 tropomyosin 2 (beta) 0.28361
TMEM205 transmembrane protein 205 0.276065
CREB3L4 cAMP responsive element binding protein 3-like 4 0.273528
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 0.265643
FES FES proto-oncogene, tyrosine kinase 0.261768
TNNI3 troponin I type 3 (cardiac) 0.25952
PCOLCE procollagen C-endopeptidase enhancer 0.257216
RPSA ribosomal protein SA 0.255989
RPL15 ribosomal protein L15 0.255512
NHP2 NHP2 ribonucleoprotein 0.253578
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 0.251492
CCND3 cyclin D3 0.246957
RPS21 ribosomal protein S21 0.246824
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 0.24334
CHLSN cholesin 0.240371
MANBAL mannosidase, beta A, lysosomal-like 0.239499
ATP5F1A ATP synthase F1 subunit alpha 0.236513
PRDX5 peroxiredoxin 5 0.229003
LMNA lamin A/C 0.226511
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.226511
MYDGF myeloid-derived growth factor 0.222333
NOTCH2 notch 2 0.222256
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.220567
MCM4 minichromosome maintenance complex component 4 0.220325
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.220325
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.217862
EIF3K eukaryotic translation initiation factor 3, subunit K 0.217758
TMEM256 transmembrane protein 256 0.217593
TMEM109 transmembrane protein 109 0.21569
GSTO1 glutathione S-transferase omega 1 0.215595
ATP5MF ATP synthase membrane subunit f 0.214617
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.210374
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.210314
ZNF90 zinc finger protein 90 0.207391
BIRC5 baculoviral IAP repeat containing 5 0.202744
TRPM2 transient receptor potential cation channel, subfamily M, member 2 0.202641
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.202276
RABAC1 Rab acceptor 1 (prenylated) 0.200308

decreased expression

Symbol Name Standardized Value
DHRS2 dehydrogenase/reductase (SDR family) member 2 -1.51468
PKM pyruvate kinase, muscle -1.0394
TLN1 talin 1 -0.988134
ACTG1 actin gamma 1 -0.986944
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.805602
YBX1 Y box binding protein 1 -0.753058
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.714568
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.672581
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.649117
EIF1 eukaryotic translation initiation factor 1 -0.630216
SENP1 SUMO1/sentrin specific peptidase 1 -0.608972
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.601487
EIF3B eukaryotic translation initiation factor 3, subunit B -0.601263
MRGBP MRG/MORF4L binding protein -0.598977
MTCH1 mitochondrial carrier 1 -0.574396
SLBP stem-loop binding protein -0.53297
SPPL2A signal peptide peptidase like 2A -0.532174
TARDBP TAR DNA binding protein -0.530267
RRM2 ribonucleotide reductase M2 -0.515532
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.509574
KPNB1 karyopherin (importin) beta 1 -0.506115
ZNF395 zinc finger protein 395 -0.491805
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -0.471149
MCM3 minichromosome maintenance complex component 3 -0.44911
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.437665
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.43123
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.388425
POTEF POTE ankyrin domain family, member F -0.385459
LRRC37B leucine rich repeat containing 37B -0.385149
TPT1 tumor protein, translationally-controlled 1 -0.379422
FEN1 flap structure-specific endonuclease 1 -0.379301
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.379301
ACTN1 actinin, alpha 1 -0.375487
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -0.374392
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.371626
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -0.36998
AFG3L2 AFG3-like AAA ATPase 2 -0.354922
YBX3 Y box binding protein 3 -0.354163
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.350256
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.344625
ATN1 atrophin 1 -0.343892
ZNF580 zinc finger protein 580 -0.343892
MAGED1 melanoma antigen family D1 -0.339494
KLC1 kinesin light chain 1 -0.330688
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.330411
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) -0.327644
RAB43 RAB43, member RAS oncogene family -0.322033
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 -0.319474
RPL6 ribosomal protein L6 -0.315969
SPATS2L spermatogenesis associated, serine-rich 2-like -0.314527
SF1 splicing factor 1 -0.311485
UBAC1 UBA domain containing 1 -0.306123
MAGEA1 melanoma antigen family A1 -0.306033
RPL3 ribosomal protein L3 -0.305583
GLRX5 glutaredoxin 5 -0.301877
CFDP1 craniofacial development protein 1 -0.296342
EWSR1 EWS RNA-binding protein 1 -0.294131
RPS4X ribosomal protein S4, X-linked -0.294007
KCMF1 potassium channel modulatory factor 1 -0.290935
TMSB4X thymosin beta 4, X-linked -0.286046
CLPTM1L CLPTM1-like -0.286046
SFPQ splicing factor proline/glutamine-rich -0.278986
BCAP31 B-cell receptor-associated protein 31 -0.278971
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.278553
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -0.277223
RPL4 ribosomal protein L4 -0.275902
NACA nascent polypeptide-associated complex alpha subunit -0.273914
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.270944
PGK1 phosphoglycerate kinase 1 -0.268811
STIP1 stress-induced phosphoprotein 1 -0.265083
JTB jumping translocation breakpoint -0.258714
PRKCSH protein kinase C substrate 80K-H -0.257008
PTMA prothymosin, alpha -0.256604
ZBTB5 zinc finger and BTB domain containing 5 -0.255066
SMTN smoothelin -0.254871
SURF4 surfeit 4 -0.253243
METTL21A methyltransferase like 21A -0.251342
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -0.248627
TUBB6 tubulin, beta 6 class V -0.246824
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.244474
C1ORF43 chromosome 1 open reading frame 43 -0.240371
UBAP2 ubiquitin associated protein 2 -0.237434
RPL27A ribosomal protein L27a -0.233102
MAGEA4 melanoma antigen family A4 -0.227859
CTSB cathepsin B -0.225074
STAMBP STAM binding protein -0.222507
MAPK14 mitogen-activated protein kinase 14 -0.221651
MRPL43 mitochondrial ribosomal protein L43 -0.22125
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -0.21942
CENPF centromere protein F, 350/400kDa -0.214091
RAN RAN, member RAS oncogene family -0.213997
CASP3 caspase 3, apoptosis-related cysteine peptidase -0.213565
MIA3 melanoma inhibitory activity family, member 3 -0.212288
CCN2 cellular communication network factor 2 -0.210314
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) -0.210314
NONO non-POU domain containing, octamer-binding -0.209654
SMYD2 SET and MYND domain containing 2 -0.20965
GPBP1 GC-rich promoter binding protein 1 -0.20965
TRIR telomerase RNA component interacting RNase -0.209434
SMIM10L1 small integral membrane protein 10 like 1 -0.207378
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing -0.206123
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.203485
SND1 staphylococcal nuclease and tudor domain containing 1 -0.202947
USP40 ubiquitin specific peptidase 40 -0.201493
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.201381