DC-59-NQ20_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, Vx-702, P38a kinase inhibitor targeting MAPK14 (Novartis, 10341154)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10341154
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Genes

210 genes differentially expressed following the DC-59-NQ20_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
S100A2 S100 calcium binding protein A2 2.08721
RPS15 ribosomal protein S15 2.00147
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.95691
MT1E metallothionein 1E 1.70077
ROMO1 reactive oxygen species modulator 1 1.66324
TAGLN transgelin 1.6493
RPL37A ribosomal protein L37a 1.60159
UBC ubiquitin C 1.58733
KRT17 keratin 17, type I 1.54522
GSTP1 glutathione S-transferase pi 1 1.52719
ATOX1 antioxidant 1 copper chaperone 1.40533
C19ORF33 chromosome 19 open reading frame 33 1.28765
SSR4 signal sequence receptor, delta 1.21326
RPS14 ribosomal protein S14 1.17263
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 1.12793
MZT2B mitotic spindle organizing protein 2B 1.0413
S100A6 S100 calcium binding protein A6 0.988331
TIMP1 TIMP metallopeptidase inhibitor 1 0.968467
RPL28 ribosomal protein L28 0.963297
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.934875
RPS27 ribosomal protein S27 0.923997
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.923997
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.918039
MLF2 myeloid leukemia factor 2 0.902357
BLVRB biliverdin reductase B 0.87896
RPLP2 ribosomal protein, large, P2 0.862196
RPL38 ribosomal protein L38 0.803307
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.787097
IL18 interleukin 18 0.767001
MYL12B myosin, light chain 12B, regulatory 0.754254
RPL18A ribosomal protein L18a 0.729025
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.685102
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.683551
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.674096
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.665937
LGALS1 lectin, galactoside-binding, soluble, 1 0.637529
MICALL1 MICAL-like 1 0.623534
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.621233
RPLP1 ribosomal protein, large, P1 0.617579
TAGLN2 transgelin 2 0.611602
RPS3 ribosomal protein S3 0.606772
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.584832
PYCR1 pyrroline-5-carboxylate reductase 1 0.580837
COX5B cytochrome c oxidase subunit Vb 0.580837
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.570067
MRPL52 mitochondrial ribosomal protein L52 0.562042
CSRP1 cysteine and glycine-rich protein 1 0.558091
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 0.51867
RPS5 ribosomal protein S5 0.517915
HSPB1 heat shock 27kDa protein 1 0.509018
KISS1 KiSS-1 metastasis-suppressor 0.489609
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 0.483304
PCSK7 proprotein convertase subtilisin/kexin type 7 0.477401
MT2A metallothionein 2A 0.469804
TRIP6 thyroid hormone receptor interactor 6 0.461836
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 0.456429
FIBCD1 fibrinogen C domain containing 1 0.451575
ISG15 ISG15 ubiquitin-like modifier 0.451283
TMEM258 transmembrane protein 258 0.447103
MTLN mitoregulin 0.434621
TSPO translocator protein (18kDa) 0.430811
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.426917
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.420849
OCIAD2 OCIA domain containing 2 0.39678
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.391925
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.391643
MFGE8 milk fat globule-EGF factor 8 protein 0.391643
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.388387
TXNRD2 thioredoxin reductase 2 0.388042
MRPS34 mitochondrial ribosomal protein S34 0.385632
TRAP1 TNF receptor-associated protein 1 0.376453
RUVBL2 RuvB-like AAA ATPase 2 0.375735
SCO2 SCO2 cytochrome c oxidase assembly protein 0.371946
MRPL36 mitochondrial ribosomal protein L36 0.370678
OLFML3 olfactomedin-like 3 0.370678
C12ORF57 chromosome 12 open reading frame 57 0.362088
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.35772
ALPL alkaline phosphatase, liver/bone/kidney 0.3574
GSDMD gasdermin D 0.356406
MAP7D1 MAP7 domain containing 1 0.353924
RPL35A ribosomal protein L35a 0.343638
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.343066
MRPL14 mitochondrial ribosomal protein L14 0.341126
CD81 CD81 molecule 0.340611
SNU13 small nuclear ribonucleoprotein 13 0.339884
SHISA5 shisa family member 5 0.338644
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.337224
GALE UDP-galactose-4-epimerase 0.334789
CST3 cystatin C 0.329094
MZT2A mitotic spindle organizing protein 2A 0.326788
RPS19 ribosomal protein S19 0.326571
OAZ1 ornithine decarboxylase antizyme 1 0.326032
PRDX2 peroxiredoxin 2 0.326032
PTPRF protein tyrosine phosphatase, receptor type, F 0.324429
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.323903
DGCR6L DiGeorge syndrome critical region gene 6-like 0.315112
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 0.311365
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.308851
TWF2 twinfilin actin binding protein 2 0.307264
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.307101
NF2 neurofibromin 2 (merlin) 0.307101
EIF3G eukaryotic translation initiation factor 3, subunit G 0.306599
FES FES proto-oncogene, tyrosine kinase 0.303187
P4HB prolyl 4-hydroxylase, beta polypeptide 0.301015
RPS29 ribosomal protein S29 0.300292
RPL31 ribosomal protein L31 0.295052
PHB2 prohibitin 2 0.292551
ARC activity-regulated cytoskeleton-associated protein 0.292188
MYDGF myeloid-derived growth factor 0.288933
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.286545
ZNRD2 zinc ribbon domain containing 2 0.286545
C5ORF46 chromosome 5 open reading frame 46 0.281028
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.2799
NOP16 NOP16 nucleolar protein 0.278939
RPL15 ribosomal protein L15 0.278852
RPS7 ribosomal protein S7 0.276763
SYTL3 synaptotagmin-like 3 0.274625
TMEM160 transmembrane protein 160 0.272317
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.272274
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.271798
HMGA1 high mobility group AT-hook 1 0.271798
PTGES2 prostaglandin E synthase 2 0.271423
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.268852
RBM38 RNA binding motif protein 38 0.260692
TMEM256 transmembrane protein 256 0.250521
RPS9 ribosomal protein S9 0.250243
GALK1 galactokinase 1 0.250104
CLIC1 chloride intracellular channel 1 0.248762
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.243051
CLMB calcimembrin 0.241409
GUK1 guanylate kinase 1 0.240136
MYL9 myosin, light chain 9, regulatory 0.238255
ASL argininosuccinate lyase 0.236506
ZDHHC8 zinc finger, DHHC-type containing 8 0.234913
METRN meteorin, glial cell differentiation regulator 0.233064
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 0.232305
GPX1 glutathione peroxidase 1 0.228374
METTL26 methyltransferase like 26 0.228352
NTHL1 nth endonuclease III-like 1 (E. coli) 0.228055
TRPM2 transient receptor potential cation channel, subfamily M, member 2 0.22147
LRRC75A leucine rich repeat containing 75A 0.220159
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.219809
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 0.219579
ZNF221 zinc finger protein 221 0.2191
TMEM9 transmembrane protein 9 0.217296
ZFAND2A zinc finger, AN1-type domain 2A 0.213489
APEH acylaminoacyl-peptide hydrolase 0.213254
CCDC85B coiled-coil domain containing 85B 0.210586
PAIP2 poly(A) binding protein interacting protein 2 0.206205
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.20576
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.204959
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit 0.201983

decreased expression

Symbol Name Standardized Value
MCM3 minichromosome maintenance complex component 3 -0.87896
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.761145
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.736952
PKM pyruvate kinase, muscle -0.678592
RRM2 ribonucleotide reductase M2 -0.665075
XPO1 exportin 1 -0.591109
KPNB1 karyopherin (importin) beta 1 -0.59061
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.553856
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.528019
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.518322
CLPTM1L CLPTM1-like -0.514033
CENPF centromere protein F, 350/400kDa -0.47736
TLN1 talin 1 -0.417328
PGK1 phosphoglycerate kinase 1 -0.416955
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.400775
SENP1 SUMO1/sentrin specific peptidase 1 -0.376453
SMIM10L1 small integral membrane protein 10 like 1 -0.373719
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.373719
RAN RAN, member RAS oncogene family -0.369007
SARAF store-operated calcium entry-associated regulatory factor -0.359689
RPS4X ribosomal protein S4, X-linked -0.356406
YBX1 Y box binding protein 1 -0.334917
PCLAF PCNA clamp associated factor -0.315946
DDIT4 DNA-damage-inducible transcript 4 -0.303187
MAGEA1 melanoma antigen family A1 -0.282607
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.278939
TMSB4X thymosin beta 4, X-linked -0.274625
MEPCE methylphosphate capping enzyme -0.274625
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.273038
CCN2 cellular communication network factor 2 -0.260692
HSPA1A heat shock 70kDa protein 1A -0.256797
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.251341
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.250714
FTH1 ferritin, heavy polypeptide 1 -0.250267
EIF1 eukaryotic translation initiation factor 1 -0.24909
TUBB6 tubulin, beta 6 class V -0.247059
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.246931
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.246902
CNN2 calponin 2 -0.245536
ACTN1 actinin, alpha 1 -0.243917
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.239952
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.239952
FEN1 flap structure-specific endonuclease 1 -0.239609
HINT1 histidine triad nucleotide binding protein 1 -0.23921
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.234821
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) -0.232305
ZNF740 zinc finger protein 740 -0.230906
RPL9 ribosomal protein L9 -0.224648
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.222177
PTMA prothymosin, alpha -0.222177
INTS4 integrator complex subunit 4 -0.219796
MUSK muscle, skeletal, receptor tyrosine kinase -0.216459
SIN3A SIN3 transcription regulator family member A -0.213842
URI1 URI1, prefoldin-like chaperone -0.209548
RPL27A ribosomal protein L27a -0.206743
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.203741
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.201983
SFPQ splicing factor proline/glutamine-rich -0.200783