DC-59-NQ20_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, Vx-702, P38a kinase inhibitor targeting MAPK14 (Novartis, 10341154)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/10341154
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Genes

122 genes differentially expressed following the DC-59-NQ20_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 1.35576
KRT17 keratin 17, type I 1.34652
CSRP1 cysteine and glycine-rich protein 1 0.935066
MT1E metallothionein 1E 0.875074
TAGLN transgelin 0.652514
TIMP1 TIMP metallopeptidase inhibitor 1 0.64233
KRT34 keratin 34, type I 0.628369
OBSL1 obscurin-like 1 0.591293
MT1X metallothionein 1X 0.531193
GSN gelsolin 0.531193
CCDC85B coiled-coil domain containing 85B 0.509124
ZNHIT1 zinc finger, HIT-type containing 1 0.507452
ATOX1 antioxidant 1 copper chaperone 0.481918
SYTL3 synaptotagmin-like 3 0.472273
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.472273
RPL28 ribosomal protein L28 0.472273
RPL38 ribosomal protein L38 0.47154
CKB creatine kinase, brain 0.440868
RPL36 ribosomal protein L36 0.43716
A1BG alpha-1-B glycoprotein 0.431566
KRTAP2-3 keratin associated protein 2-3 0.428977
MRPL13 mitochondrial ribosomal protein L13 0.428977
METRN meteorin, glial cell differentiation regulator 0.414648
SF3B5 splicing factor 3b, subunit 5, 10kDa 0.410645
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.384481
RPL18 ribosomal protein L18 0.381404
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 0.379838
RPS15 ribosomal protein S15 0.3787
RPS18 ribosomal protein S18 0.372548
CCDC167 coiled-coil domain containing 167 0.369168
RPL37 ribosomal protein L37 0.369035
RPLP2 ribosomal protein, large, P2 0.368862
RPS27 ribosomal protein S27 0.362894
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.356837
OCIAD2 OCIA domain containing 2 0.354015
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.345322
SLC25A39 solute carrier family 25, member 39 0.312313
MRPS34 mitochondrial ribosomal protein S34 0.311871
UBL5 ubiquitin-like 5 0.305533
RPL8 ribosomal protein L8 0.300414
RPL37A ribosomal protein L37a 0.300414
BABAM2 BRISC and BRCA1 A complex member 2 0.287929
PAQR4 progestin and adipoQ receptor family member IV 0.287013
REEP2 receptor accessory protein 2 0.287013
SYP synaptophysin 0.285689
CST3 cystatin C 0.283211
TMSB10 thymosin beta 10 0.279348
CLU clusterin 0.272413
C19ORF81 chromosome 19 open reading frame 81 0.267449
IL18 interleukin 18 0.267284
OST4 oligosaccharyltransferase 4 homolog (S. cerevisiae) 0.260743
ETHE1 ethylmalonic encephalopathy 1 0.258364
RABAC1 Rab acceptor 1 (prenylated) 0.255331
RPS14 ribosomal protein S14 0.250036
LY6E lymphocyte antigen 6 complex, locus E 0.250036
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.24931
FXYD1 FXYD domain containing ion transport regulator 1 0.248668
CISD3 CDGSH iron sulfur domain 3 0.247071
CIAO2B cytosolic iron-sulfur assembly component 2B 0.24596
UQCC3 ubiquinol-cytochrome c reductase complex assembly factor 3 0.244764
MFGE8 milk fat globule-EGF factor 8 protein 0.241441
SERF2 small EDRK-rich factor 2 0.234141
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.230291
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.22979
HLA-B major histocompatibility complex, class I, B 0.222802
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.220259
GALK1 galactokinase 1 0.220259
RPL41 ribosomal protein L41 0.219548
TGFBI transforming growth factor, beta-induced, 68kDa 0.219548
PTPRF protein tyrosine phosphatase, receptor type, F 0.217987
TUSC2 tumor suppressor candidate 2 0.214676
TUFM Tu translation elongation factor, mitochondrial 0.21467
PPP1R35 protein phosphatase 1, regulatory subunit 35 0.210866
PIH1D1 PIH1 domain containing 1 0.206603
MRPL41 mitochondrial ribosomal protein L41 0.206603
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.205668
HLA-A major histocompatibility complex, class I, A 0.204913
CHLSN cholesin 0.204184
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.202015
GSTP1 glutathione S-transferase pi 1 0.201307

decreased expression

Symbol Name Standardized Value
DDIT4 DNA-damage-inducible transcript 4 -2.30878
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -1.34652
CLPTM1L CLPTM1-like -1.25733
CPA4 carboxypeptidase A4 -0.791522
CXCL14 chemokine (C-X-C motif) ligand 14 -0.688117
HAPLN1 hyaluronan and proteoglycan link protein 1 -0.652514
TNNT2 troponin T type 2 (cardiac) -0.527432
GLS2 glutaminase 2 (liver, mitochondrial) -0.481492
ANXA8L1 annexin A8-like 1 -0.446797
KPNB1 karyopherin (importin) beta 1 -0.44281
SERTAD4 SERTA domain containing 4 -0.44281
MAB21L4 mab-21 like 4 -0.440868
FOXS1 forkhead box S1 -0.431566
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.431566
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.384481
ANAPC16 anaphase promoting complex subunit 16 -0.369168
MEPCE methylphosphate capping enzyme -0.369168
SUMO2 small ubiquitin-like modifier 2 -0.362894
CAV1 caveolin 1, caveolae protein, 22kDa -0.352565
CBX5 chromobox homolog 5 -0.331203
GPC1 glypican 1 -0.314128
FOXN3 forkhead box N3 -0.291773
LRRC37B leucine rich repeat containing 37B -0.279424
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.273796
RNPS1 RNA binding protein S1, serine-rich domain -0.272413
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.262677
RRM2 ribonucleotide reductase M2 -0.258702
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.250249
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.250036
MAGED1 melanoma antigen family D1 -0.248736
RBM39 RNA binding motif protein 39 -0.237631
CUL2 cullin 2 -0.237277
EMC10 ER membrane protein complex subunit 10 -0.23205
MN1 meningioma (disrupted in balanced translocation) 1 -0.225331
FASN fatty acid synthase -0.220144
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.219548
ILF3 interleukin enhancer binding factor 3, 90kDa -0.215314
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -0.210866
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.206347
MCM3 minichromosome maintenance complex component 3 -0.205668
EI24 etoposide induced 2.4 -0.201307
WNT5B wingless-type MMTV integration site family, member 5B -0.201167