DC-99-NQ50_0.01uM Gene Set

Dataset	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category	transcriptomics
Type	drug perturbation
Description	Dose=0.01uM, 4-methyl-2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide, SCD inhibitor targeting SCD (Novartis, 25095148)
External Link	https://pubchem.ncbi.nlm.nih.gov/compound/25095148
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Genes

16 genes differentially expressed following the DC-99-NQ50_0.01uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol	Name	Standardized Value
FAU	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed	1.02528
ROMO1	reactive oxygen species modulator 1	0.369427
RPL37A	ribosomal protein L37a	0.331297
COX6A1	cytochrome c oxidase subunit VIa polypeptide 1	0.264267
RPLP2	ribosomal protein, large, P2	0.211684
RPS7	ribosomal protein S7	0.205978
RPS3	ribosomal protein S3	0.205978

decreased expression

Symbol	Name	Standardized Value
MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	-0.777474
RPL11	ribosomal protein L11	-0.391069
MAGED1	melanoma antigen family D1	-0.356803
BRD9	bromodomain containing 9	-0.353954
HLA-B	major histocompatibility complex, class I, B	-0.331297
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	-0.277136
KIAA0319L	KIAA0319-like	-0.260243
HDGFL3	HDGF like 3	-0.246858
FXYD6-FXYD2	FXYD6-FXYD2 readthrough	-0.221461