DC-99-NQ50_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, 4-methyl-2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide, SCD inhibitor targeting SCD (Novartis, 25095148)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/25095148
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Genes

36 genes differentially expressed following the DC-99-NQ50_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.608229
LGALS1 lectin, galactoside-binding, soluble, 1 0.36747
RPS3 ribosomal protein S3 0.36747
DDTL D-dopachrome tautomerase-like 0.361503
RPS7 ribosomal protein S7 0.35708
RPL38 ribosomal protein L38 0.325069
RPS5 ribosomal protein S5 0.304001
RPL13A ribosomal protein L13a 0.292926
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.292926
ATP5PO ATP synthase peripheral stalk subunit OSCP 0.28109
RPS18 ribosomal protein S18 0.275853
ELOB elongin B 0.275606
RPL18 ribosomal protein L18 0.274991
RPL27 ribosomal protein L27 0.262056
RPL34 ribosomal protein L34 0.262056
IFI35 interferon-induced protein 35 0.262056
RPS21 ribosomal protein S21 0.261029
RPS12 ribosomal protein S12 0.254163
ATP5MF ATP synthase membrane subunit f 0.252202
RPL36 ribosomal protein L36 0.230898
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.226882
UPP1 uridine phosphorylase 1 0.226882
RPL37 ribosomal protein L37 0.212979
RPLP0 ribosomal protein, large, P0 0.206277
RPS14 ribosomal protein S14 0.201592

decreased expression

Symbol Name Standardized Value
TBC1D10A TBC1 domain family, member 10A -0.346303
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.292926
RALY RALY heterogeneous nuclear ribonucleoprotein -0.292926
CAVIN1 caveolae associated protein 1 -0.292926
ACTG1 actin gamma 1 -0.25802
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -0.254163
PKM pyruvate kinase, muscle -0.226882
POTEF POTE ankyrin domain family, member F -0.201592
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.201592
SPHK1 sphingosine kinase 1 -0.201592
RSAD1 radical S-adenosyl methionine domain containing 1 -0.200268