DCA_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/DCA_UP.V1_UP
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Genes

376 genes differentially expressed following the DCA_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADAM19 ADAM metallopeptidase domain 19
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
AHSP alpha hemoglobin stabilizing protein
AIF1 allograft inflammatory factor 1
AK4P3 adenylate kinase 4 pseudogene 3
AK5 adenylate kinase 5
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANKRD53 ankyrin repeat domain 53
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ATF6 activating transcription factor 6
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
AURKB aurora kinase B
BCAS4 breast carcinoma amplified sequence 4
BEST1 bestrophin 1
BFSP1 beaded filament structural protein 1, filensin
BMX BMX non-receptor tyrosine kinase
BTN3A1 butyrophilin, subfamily 3, member A1
C10ORF10 chromosome 10 open reading frame 10
C1ORF105 chromosome 1 open reading frame 105
C22ORF31 chromosome 22 open reading frame 31
CA6 carbonic anhydrase VI
CABIN1 calcineurin binding protein 1
CACNG5 calcium channel, voltage-dependent, gamma subunit 5
CAPN11 calpain 11
CASP2 caspase 2, apoptosis-related cysteine peptidase
CATSPERB catsper channel auxiliary subunit beta
CCDC71 coiled-coil domain containing 71
CCDC87 coiled-coil domain containing 87
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2
CD1B CD1b molecule
CD27 CD27 molecule
CD70 CD70 molecule
CD82 CD82 molecule
CDC45 cell division cycle 45
CETN1 centrin, EF-hand protein, 1
CFAP70 cilia and flagella associated protein 70
CLCN2 chloride channel, voltage-sensitive 2
CLEC7A C-type lectin domain family 7, member A
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNGB3 cyclic nucleotide gated channel beta 3
COBL cordon-bleu WH2 repeat protein
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
COPG2 coatomer protein complex, subunit gamma 2
COPZ2 coatomer protein complex, subunit zeta 2
CORT cortistatin
CREB5 cAMP responsive element binding protein 5
CRIP2 cysteine-rich protein 2
CRYGB crystallin, gamma B
CST2 cystatin SA
CTSG cathepsin G
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43
DCXR dicarbonyl/L-xylulose reductase
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAL4 dynein, axonemal, light chain 4
DPP6 dipeptidyl-peptidase 6
EFS embryonal Fyn-associated substrate
EIF3FP2 eukaryotic translation initiation factor 3, subunit F pseudogene 2
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EPHB6 EPH receptor B6
EXO5 exonuclease 5
EYA2 EYA transcriptional coactivator and phosphatase 2
F2 coagulation factor II (thrombin)
FAM215A family with sequence similarity 215, member A (non-protein coding)
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF22 fibroblast growth factor 22
FGF6 fibroblast growth factor 6
FMO6P flavin containing monooxygenase 6 pseudogene
FRMPD1 FERM and PDZ domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GIPR gastric inhibitory polypeptide receptor
GLS2 glutaminase 2 (liver, mitochondrial)
GPA33 glycoprotein A33 (transmembrane)
GPR45 G protein-coupled receptor 45
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GRM5 glutamate receptor, metabotropic 5
HCG9 HLA complex group 9 (non-protein coding)
HHLA1 HERV-H LTR-associating 1
HIST1H2BI histone cluster 1, H2bi
HOXC5 homeobox C5
HTN1 histatin 1
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA10 interferon, alpha 10
IGKV3D-15 immunoglobulin kappa variable 3D-15 (gene/pseudogene)
IGLV2-14 immunoglobulin lambda variable 2-14
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL36RN interleukin 36 receptor antagonist
INO80B INO80 complex subunit B
INSL3 insulin-like 3 (Leydig cell)
IRGC immunity-related GTPase family, cinema
IRX4 iroquois homeobox 4
ITGA8 integrin, alpha 8
KIAA0513 KIAA0513
KIAA1107 KIAA1107
KIF17 kinesin family member 17
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL3 kelch-like family member 3
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KREMEN2 kringle containing transmembrane protein 2
KRT13 keratin 13, type I
LAMC3 laminin, gamma 3
LGALS7 lectin, galactoside-binding, soluble, 7
LIMD1 LIM domains containing 1
LINC00341 long intergenic non-protein coding RNA 341
LOC79999 uncharacterized LOC79999
LPAR3 lysophosphatidic acid receptor 3
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAPK8 mitogen-activated protein kinase 8
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
MCTP2 multiple C2 domains, transmembrane 2
MDK midkine (neurite growth-promoting factor 2)
MIR600HG MIR600 host gene
MOGAT2 monoacylglycerol O-acyltransferase 2
MX1 MX dynamin-like GTPase 1
MYCT1 myc target 1
MYOZ3 myozenin 3
NPC1L1 NPC1-like 1
NRXN2 neurexin 2
NTN3 netrin 3
OR3A2 olfactory receptor, family 3, subfamily A, member 2
OVGP1 oviductal glycoprotein 1, 120kDa
OXCT2 3-oxoacid CoA transferase 2
PAK1IP1 PAK1 interacting protein 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIGV phosphatidylinositol glycan anchor biosynthesis, class V
PLA2G2F phospholipase A2, group IIF
PLAA phospholipase A2-activating protein
PNMT phenylethanolamine N-methyltransferase
PQLC3 PQ loop repeat containing 3
PRDM14 PR domain containing 14
PRO2964 uncharacterized protein PRO2964
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTGFR prostaglandin F receptor (FP)
PTPRT protein tyrosine phosphatase, receptor type, T
RAI1 retinoic acid induced 1
RIMS2 regulating synaptic membrane exocytosis 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPE65 retinal pigment epithelium-specific protein 65kDa
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RRP7BP ribosomal RNA processing 7 homolog B (S. cerevisiae), pseudogene
SARDH sarcosine dehydrogenase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHCBP1L SHC SH2-domain binding protein 1-like
SIX1 SIX homeobox 1
SLC22A14 solute carrier family 22, member 14
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SMA4 glucuronidase, beta pseudogene
SNX17 sorting nexin 17
SOS2 son of sevenless homolog 2 (Drosophila)
SPIN2A spindlin family, member 2A
TACR3 tachykinin receptor 3
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEX13B testis expressed 13B
TNNT2 troponin T type 2 (cardiac)
TNS4 tensin 4
TSKS testis-specific serine kinase substrate
TTLL3 tubulin tyrosine ligase-like family member 3
TYRO3 TYRO3 protein tyrosine kinase
USF2 upstream transcription factor 2, c-fos interacting
USP29 ubiquitin specific peptidase 29
USP6NL USP6 N-terminal like
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WASL Wiskott-Aldrich syndrome-like
WDR25 WD repeat domain 25
WISP1 WNT1 inducible signaling pathway protein 1
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
ZNF117 zinc finger protein 117
ZNF157 zinc finger protein 157
ZNF185 zinc finger protein 185 (LIM domain)
ZNF639 zinc finger protein 639
ZNF750 zinc finger protein 750
ZNF91 zinc finger protein 91
ZSCAN12 zinc finger and SCAN domain containing 12
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACIN1 apoptotic chromatin condensation inducer 1
ADGRF5 adhesion G protein-coupled receptor F5
ADM2 adrenomedullin 2
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALK anaplastic lymphoma receptor tyrosine kinase
ANAPC10 anaphase promoting complex subunit 10
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANKRD46 ankyrin repeat domain 46
ARHGAP15 Rho GTPase activating protein 15
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ASIC4 acid sensing (proton gated) ion channel family member 4
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP10D ATPase, class V, type 10D
AUNIP aurora kinase A and ninein interacting protein
C10ORF12 chromosome 10 open reading frame 12
C1ORF109 chromosome 1 open reading frame 109
C2CD2L C2CD2-like
CA5A carbonic anhydrase VA, mitochondrial
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CDH16 cadherin 16, KSP-cadherin
CDK10 cyclin-dependent kinase 10
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDON cell adhesion associated, oncogene regulated
CHEK2 checkpoint kinase 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLIC5 chloride intracellular channel 5
CMC1 C-x(9)-C motif containing 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNTLN centlein, centrosomal protein
COL21A1 collagen, type XXI, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CST7 cystatin F (leukocystatin)
CTAG2 cancer/testis antigen 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
DCAF13 DDB1 and CUL4 associated factor 13
DCAF17 DDB1 and CUL4 associated factor 17
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
ENO3 enolase 3 (beta, muscle)
ETNPPL ethanolamine-phosphate phospho-lyase
FAM204A family with sequence similarity 204, member A
FAM222B family with sequence similarity 222, member B
FGF9 fibroblast growth factor 9
FGR FGR proto-oncogene, Src family tyrosine kinase
FLJ10038 uncharacterized protein FLJ10038
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GALR3 galanin receptor 3
GMPR guanosine monophosphate reductase
GPR137B G protein-coupled receptor 137B
GPR19 G protein-coupled receptor 19
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRAMD4 GRAM domain containing 4
GRID2 glutamate receptor, ionotropic, delta 2
GSDMD gasdermin D
HIST1H3D histone cluster 1, H3d
IFNA5 interferon, alpha 5
IFNG interferon, gamma
IGLJ3 immunoglobulin lambda joining 3
IL10RA interleukin 10 receptor, alpha
INSL5 insulin-like 5
IP6K2 inositol hexakisphosphate kinase 2
IPCEF1 interaction protein for cytohesin exchange factors 1
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
JOSD1 Josephin domain containing 1
KATNBL1 katanin p80 subunit B-like 1
KCTD3 potassium channel tetramerization domain containing 3
KIAA0894 KIAA0894 protein
KLHL1 kelch-like family member 1
KRT1 keratin 1, type II
KRT24 keratin 24, type I
KRT5 keratin 5, type II
LAMA3 laminin, alpha 3
LAT linker for activation of T cells
LIN7B lin-7 homolog B (C. elegans)
LONP2 lon peptidase 2, peroxisomal
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC14 leucine rich repeat containing 14
LRRC37A2 leucine rich repeat containing 37, member A2
MAGEB3 melanoma antigen family B3
MAGEH1 melanoma antigen family H1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MATN4 matrilin 4
MCTP1 multiple C2 domains, transmembrane 1
MED23 mediator complex subunit 23
MFGE8 milk fat globule-EGF factor 8 protein
MFSD12 major facilitator superfamily domain containing 12
MGC2889 uncharacterized protein MGC2889
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSH5 mutS homolog 5
MTRF1 mitochondrial translational release factor 1
MYL10 myosin, light chain 10, regulatory
N4BP2L2 NEDD4 binding protein 2-like 2
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NFASC neurofascin
NOL8 nucleolar protein 8
NOTCH2NL notch 2 N-terminal like
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUMB numb homolog (Drosophila)
NUP62 nucleoporin 62kDa
NXF2 nuclear RNA export factor 2
OR11A1 olfactory receptor, family 11, subfamily A, member 1
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PES1 pescadillo ribosomal biogenesis factor 1
PEX19 peroxisomal biogenesis factor 19
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PKP1 plakophilin 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLK3 polo-like kinase 3
POGLUT1 protein O-glucosyltransferase 1
POR P450 (cytochrome) oxidoreductase
PPCDC phosphopantothenoylcysteine decarboxylase
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R17 protein phosphatase 1, regulatory subunit 17
PRPF38B pre-mRNA processing factor 38B
PRRX2 paired related homeobox 2
PTPRG protein tyrosine phosphatase, receptor type, G
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RALGDS ral guanine nucleotide dissociation stimulator
RASL10A RAS-like, family 10, member A
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBM14 RNA binding motif protein 14
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RS1 retinoschisin 1
RSG1 REM2 and RAB-like small GTPase 1
S100A14 S100 calcium binding protein A14
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETBP1 SET binding protein 1
SETD4 SET domain containing 4
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SHOX2 short stature homeobox 2
SIAH2 siah E3 ubiquitin protein ligase 2
SIRPB1 signal-regulatory protein beta 1
SKIL SKI-like proto-oncogene
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC22A17 solute carrier family 22, member 17
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC35F6 solute carrier family 35, member F6
SLC38A3 solute carrier family 38, member 3
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SNCB synuclein, beta
SNX24 sorting nexin 24
SP140L SP140 nuclear body protein-like
SPC25 SPC25, NDC80 kinetochore complex component
SPRR1A small proline-rich protein 1A
STAG3 stromal antigen 3
STARD3 StAR-related lipid transfer (START) domain containing 3
STEAP1B STEAP family member 1B
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBX6 T-box 6
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TCL1A T-cell leukemia/lymphoma 1A
TCL1B T-cell leukemia/lymphoma 1B
TDRD7 tudor domain containing 7
TG thyroglobulin
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM115 transmembrane protein 115
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNRC18 trinucleotide repeat containing 18
TRIM52 tripartite motif containing 52
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TXLNA taxilin alpha
UPK1A uroplakin 1A
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WDR91 WD repeat domain 91
YIPF3 Yip1 domain family, member 3
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZCCHC24 zinc finger, CCHC domain containing 24
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF248 zinc finger protein 248
ZNF286A zinc finger protein 286A
ZNF32 zinc finger protein 32
ZNF652 zinc finger protein 652
ZNF821 zinc finger protein 821
ZNF84 zinc finger protein 84