DCC Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description DCC netrin 1 receptor|This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 1630)
External Link http://www.ncbi.nlm.nih.gov/gene/1630
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143 interacting proteins for DCC from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ALB albumin
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
AR androgen receptor
BARD1 BRCA1 associated RING domain 1
BBC3 BCL2 binding component 3
CABLES1 Cdk5 and Abl enzyme substrate 1
CAMTA1 calmodulin binding transcription activator 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CEP44 centrosomal protein 44kDa
CLCA2 chloride channel accessory 2
CNOT1 CCR4-NOT transcription complex, subunit 1
CROT carnitine O-octanoyltransferase
DGKG diacylglycerol kinase, gamma 90kDa
DICER1 dicer 1, ribonuclease type III
DMD dystrophin
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
E2F1 E2F transcription factor 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF4E eukaryotic translation initiation factor 4E
EIF4E3 eukaryotic translation initiation factor 4E family member 3
EIF5A2 eukaryotic translation initiation factor 5A2
EZR ezrin
F2 coagulation factor II (thrombin)
FYN FYN proto-oncogene, Src family tyrosine kinase
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GRAP2 GRB2-related adaptor protein 2
HBA2 hemoglobin, alpha 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB5 integrin, beta 5
JARID2 jumonji, AT rich interactive domain 2
KIAA1551 KIAA1551
KRT1 keratin 1, type II
KRT10 keratin 10, type I
LAT linker for activation of T cells
LDB3 LIM domain binding 3
MAP1B microtubule-associated protein 1B
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK3 myosin light chain kinase 3
MYO10 myosin X
NCK1 NCK adaptor protein 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NLRC4 NLR family, CARD domain containing 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NTN1 netrin 1
NTN4 netrin 4
PALB2 partner and localizer of BRCA2
PCED1B PC-esterase domain containing 1B
PDZRN4 PDZ domain containing ring finger 4
PEG3 paternally expressed 3
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNA phosphatidylinositol transfer protein, alpha
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRSS1 protease, serine, 1 (trypsin 1)
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RANBP3 RAN binding protein 3
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOU ras homolog family member U
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL10A ribosomal protein L10a
RPL13 ribosomal protein L13
RPL23 ribosomal protein L23
RPL28 ribosomal protein L28
RPL38 ribosomal protein L38
RPL5 ribosomal protein L5
RPS10 ribosomal protein S10
RPS13 ribosomal protein S13
RPS23 ribosomal protein S23
RPS24 ribosomal protein S24
RPS4X ribosomal protein S4, X-linked
RPS6 ribosomal protein S6
SCN5A sodium channel, voltage gated, type V alpha subunit
SETX senataxin
SGOL2 shugoshin-like 2 (S. pombe)
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLA2 Src-like-adaptor 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLIT1 slit homolog 1 (Drosophila)
SLIT2 slit homolog 2 (Drosophila)
SLIT3 slit homolog 3 (Drosophila)
SORBS3 sorbin and SH3 domain containing 3
SPAST spastin
SPATA31A7 SPATA31 subfamily A, member 7
SRC SRC proto-oncogene, non-receptor tyrosine kinase
THRAP3 thyroid hormone receptor associated protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN2 talin 2
TRAPPC11 trafficking protein particle complex 11
TRIO trio Rho guanine nucleotide exchange factor
TTN titin
UBC ubiquitin C
VASP vasodilator-stimulated phosphoprotein