DD-16-GL76_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, Memantine, NMDA Antagonists targeting GRIN2A, GRIN2B (Novartis, 4054)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/4054
Similar Terms
Downloads & Tools

Genes

24 genes differentially expressed following the DD-16-GL76_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
APRT adenine phosphoribosyltransferase 0.517882
PHPT1 phosphohistidine phosphatase 1 0.478549
RPS15 ribosomal protein S15 0.408293
SCAND1 SCAN domain containing 1 0.322206
SSR4 signal sequence receptor, delta 0.301863
LOC112694756 uncharaterized LOC112694756 0.293253
COX5B cytochrome c oxidase subunit Vb 0.277598
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.277598
RBM38 RNA binding motif protein 38 0.25787
RPL18 ribosomal protein L18 0.237453
BLVRB biliverdin reductase B 0.216292
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.216144
KRT17 keratin 17, type I 0.216144
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.216144
RPL38 ribosomal protein L38 0.216144
HSPB1 heat shock 27kDa protein 1 0.215689
UCK2 uridine-cytidine kinase 2 0.211819
PPP4C protein phosphatase 4, catalytic subunit 0.210512
FIBP fibroblast growth factor (acidic) intracellular binding protein 0.201063

decreased expression

Symbol Name Standardized Value
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -0.478549
GLRX5 glutaredoxin 5 -0.301863
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.261074
CCNG1 cyclin G1 -0.2499
AFF4 AF4/FMR2 family, member 4 -0.215689