DD-55-SD64_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, 4-(8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl)benzoic acid, Phosphodiesterase IV Inhibitors targeting PDE4C (Novartis, 9999276)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9999276
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Genes

50 genes differentially expressed following the DD-55-SD64_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
APRT adenine phosphoribosyltransferase 1.81633
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 1.69422
RPL18A ribosomal protein L18a 0.825747
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.686809
ATOX1 antioxidant 1 copper chaperone 0.686809
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.485321
KRT81 keratin 81, type II 0.460144
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 0.452149
CSNK2B casein kinase 2, beta polypeptide 0.443853
VTA1 vesicle (multivesicular body) trafficking 1 0.42054
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.401703
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.385843
RPS27 ribosomal protein S27 0.338449
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.31619
HSPB1 heat shock 27kDa protein 1 0.314088
PHPT1 phosphohistidine phosphatase 1 0.310585
SSR4 signal sequence receptor, delta 0.309671
RPS5 ribosomal protein S5 0.304962
MZT2B mitotic spindle organizing protein 2B 0.28369
PRDX5 peroxiredoxin 5 0.27966
RPS15 ribosomal protein S15 0.27966
MTLN mitoregulin 0.27966
ROMO1 reactive oxygen species modulator 1 0.262238
RPLP1 ribosomal protein, large, P1 0.262238
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.262238
RPS18 ribosomal protein S18 0.258176
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.257831
RPL15 ribosomal protein L15 0.256115
RPP21 ribonuclease P/MRP 21kDa subunit 0.242105
MT1X metallothionein 1X 0.237824
LGALS1 lectin, galactoside-binding, soluble, 1 0.236354
CENPX centromere protein X 0.226494
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.226494
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.223021
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 0.215962
FES FES proto-oncogene, tyrosine kinase 0.211512
RPL28 ribosomal protein L28 0.208205
RPL18 ribosomal protein L18 0.207221
METTL26 methyltransferase like 26 0.205338
MICOS13 mitochondrial contact site and cristae organizing system subunit 13 0.203937

decreased expression

Symbol Name Standardized Value
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.337237
MAGEA4 melanoma antigen family A4 -0.271779
CDC23 cell division cycle 23 -0.242105
SRSF2 serine/arginine-rich splicing factor 2 -0.238695
EIF4E eukaryotic translation initiation factor 4E -0.232224
MAGEA12 melanoma antigen family A12 -0.229591
FOXF2 forkhead box F2 -0.225066
MAGEA3 melanoma antigen family A3 -0.222246
XPO1 exportin 1 -0.215289
AP5M1 adaptor-related protein complex 5, mu 1 subunit -0.202028