DD-55-SD64_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, 4-(8-(3-Nitrophenyl)-1,7-naphthyridin-6-yl)benzoic acid, Phosphodiesterase IV Inhibitors targeting PDE4C (Novartis, 9999276)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9999276
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Genes

88 genes differentially expressed following the DD-55-SD64_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 1.77844
APRT adenine phosphoribosyltransferase 1.45172
LGALS1 lectin, galactoside-binding, soluble, 1 0.764638
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.730222
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.658324
CSNK2B casein kinase 2, beta polypeptide 0.628167
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.605557
RPL18A ribosomal protein L18a 0.560974
RPS29 ribosomal protein S29 0.491473
ROMO1 reactive oxygen species modulator 1 0.490545
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.381844
ELOB elongin B 0.381844
ATP5IF1 ATP synthase inhibitory factor subunit 1 0.381844
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.370007
SF3B6 splicing factor 3b, subunit 6, 14kDa 0.346074
RPL37 ribosomal protein L37 0.346074
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.335401
RPS9 ribosomal protein S9 0.325821
CDC20 cell division cycle 20 0.324935
RPS13 ribosomal protein S13 0.324154
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.319475
COX5B cytochrome c oxidase subunit Vb 0.315171
TMEM258 transmembrane protein 258 0.310894
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.305308
RPL35 ribosomal protein L35 0.296866
C19ORF33 chromosome 19 open reading frame 33 0.282434
UBE2T ubiquitin-conjugating enzyme E2T 0.278966
RPLP2 ribosomal protein, large, P2 0.277478
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 0.277082
TMSB10 thymosin beta 10 0.275963
PFDN5 prefoldin subunit 5 0.271477
PTTG1 pituitary tumor-transforming 1 0.260784
ATP5F1E ATP synthase F1 subunit epsilon 0.257437
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.254338
RPS15 ribosomal protein S15 0.242836
IFI27L2 interferon, alpha-inducible protein 27-like 2 0.240122
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.238401
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 0.236052
PHPT1 phosphohistidine phosphatase 1 0.229832
MRPL41 mitochondrial ribosomal protein L41 0.226651
RPL28 ribosomal protein L28 0.226234
RPA3 replication protein A3, 14kDa 0.225228
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 0.224585
SSR4 signal sequence receptor, delta 0.224585
RPS27A ribosomal protein S27a 0.224585
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.224585
RPL36 ribosomal protein L36 0.221628
RPS27 ribosomal protein S27 0.221628
RPS18 ribosomal protein S18 0.218571
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.218571
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.214326
MRPS21 mitochondrial ribosomal protein S21 0.21322
RPL30 ribosomal protein L30 0.212658
MRPL13 mitochondrial ribosomal protein L13 0.211843
C12ORF57 chromosome 12 open reading frame 57 0.211292
ATP5PO ATP synthase peripheral stalk subunit OSCP 0.210405
ANXA2 annexin A2 0.209804
VTA1 vesicle (multivesicular body) trafficking 1 0.209804
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.209804
UXT ubiquitously-expressed, prefoldin-like chaperone 0.208945

decreased expression

Symbol Name Standardized Value
KIF23 kinesin family member 23 -0.603284
IFFO2 intermediate filament family orphan 2 -0.530386
FSCN1 fascin actin-bundling protein 1 -0.453251
PTDSS1 phosphatidylserine synthase 1 -0.348461
SSH1 slingshot protein phosphatase 1 -0.346074
ATAD3A ATPase family, AAA domain containing 3A -0.289397
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.286588
LDLR low density lipoprotein receptor -0.281088
PGM1 phosphoglucomutase 1 -0.278331
PCBP1 poly(rC) binding protein 1 -0.278331
PKM pyruvate kinase, muscle -0.277082
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -0.271477
WFS1 Wolfram syndrome 1 (wolframin) -0.269378
HM13 histocompatibility (minor) 13 -0.257811
ZNHIT6 zinc finger, HIT-type containing 6 -0.249262
ESYT1 extended synaptotagmin-like protein 1 -0.232955
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.226651
FLNC filamin C, gamma -0.222239
COL1A1 collagen, type I, alpha 1 -0.218571
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -0.217789
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -0.214326
SCRN1 secernin 1 -0.209804
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.209804
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.2081
ARL5B ADP-ribosylation factor-like 5B -0.203278
YBX3 Y box binding protein 3 -0.203278
LIN28A lin-28 homolog A (C. elegans) -0.201035
TMED3 transmembrane emp24 protein transport domain containing 3 -0.201035