DDB1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description damage-specific DNA binding protein 1, 127kDa|The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 1642)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_DDB1
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Genes

241 co-expressed genes for DDB1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ABR active BCR-related
ACTL6A actin-like 6A
ACTN4 actinin, alpha 4
ADAM15 ADAM metallopeptidase domain 15
AFG3L2 AFG3-like AAA ATPase 2
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AHCYL1 adenosylhomocysteinase-like 1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALG3 ALG3, alpha-1,3- mannosyltransferase
ANKRD17 ankyrin repeat domain 17
AP3B1 adaptor-related protein complex 3, beta 1 subunit
ARCN1 archain 1
ATG9A autophagy related 9A
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATXN2 ataxin 2
ATXN2L ataxin 2-like
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
BAHD1 bromo adjacent homology domain containing 1
BECN1 beclin 1, autophagy related
BMS1 BMS1 ribosome biogenesis factor
BPHL biphenyl hydrolase-like (serine hydrolase)
BRD3 bromodomain containing 3
BRD8 bromodomain containing 8
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CANX calnexin
CAPZB capping protein (actin filament) muscle Z-line, beta
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CDC25C cell division cycle 25C
CDK2 cyclin-dependent kinase 2
CETN3 centrin, EF-hand protein, 3
CHD3 chromodomain helicase DNA binding protein 3
CIB1 calcium and integrin binding 1 (calmyrin)
CLSTN1 calsyntenin 1
CLTC clathrin, heavy chain (Hc)
CNOT3 CCR4-NOT transcription complex, subunit 3
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COPS6 COP9 signalosome subunit 6
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CS citrate synthase
CSNK1D casein kinase 1, delta
CSNK1G2 casein kinase 1, gamma 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTDNEP1 CTD nuclear envelope phosphatase 1
CUL1 cullin 1
CUL4B cullin 4B
DAP3 death associated protein 3
DAXX death-domain associated protein
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DENND4A DENN/MADD domain containing 4A
DEXI Dexi homolog (mouse)
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DOCK3 dedicator of cytokinesis 3
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DRG1 developmentally regulated GTP binding protein 1
EBP emopamil binding protein (sterol isomerase)
EHBP1 EH domain binding protein 1
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF6 eukaryotic translation initiation factor 6
ELK1 ELK1, member of ETS oncogene family
EML3 echinoderm microtubule associated protein like 3
EPRS glutamyl-prolyl-tRNA synthetase
ERCC2 excision repair cross-complementation group 2
ESYT1 extended synaptotagmin-like protein 1
EXTL3 exostosin-like glycosyltransferase 3
FAM189B family with sequence similarity 189, member B
FANCG Fanconi anemia, complementation group G
FDXR ferredoxin reductase
FOXK2 forkhead box K2
GLUD1 glutamate dehydrogenase 1
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GOLGA3 golgin A3
GPAA1 glycosylphosphatidylinositol anchor attachment 1
HLTF helicase-like transcription factor
HMGN4 high mobility group nucleosomal binding domain 4
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSPA8 heat shock 70kDa protein 8
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IDH3B isocitrate dehydrogenase 3 (NAD+) beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
ILF2 interleukin enhancer binding factor 2
ILK integrin-linked kinase
ILVBL ilvB (bacterial acetolactate synthase)-like
KAT2A K(lysine) acetyltransferase 2A
KDM3B lysine (K)-specific demethylase 3B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0195 KIAA0195
KPNA6 karyopherin alpha 6 (importin alpha 7)
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LRPPRC leucine-rich pentatricopeptide repeat containing
MARS methionyl-tRNA synthetase
MCM2 minichromosome maintenance complex component 2
MEA1 male-enhanced antigen 1
METAP1 methionyl aminopeptidase 1
MFN2 mitofusin 2
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLEC malectin
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MPST mercaptopyruvate sulfurtransferase
MRPL28 mitochondrial ribosomal protein L28
MTX1 metaxin 1
MYCBP MYC binding protein
NAP1L4 nucleosome assembly protein 1-like 4
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NCOR2 nuclear receptor corepressor 2
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NELFB negative elongation factor complex member B
NFRKB nuclear factor related to kappaB binding protein
NFYB nuclear transcription factor Y, beta
NONO non-POU domain containing, octamer-binding
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUP188 nucleoporin 188kDa
NUP62 nucleoporin 62kDa
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PARG poly (ADP-ribose) glycohydrolase
PARN poly(A)-specific ribonuclease
PARP2 poly (ADP-ribose) polymerase 2
PCBP3 poly(rC) binding protein 3
PCGF1 polycomb group ring finger 1
PCGF2 polycomb group ring finger 2
PDAP1 PDGFA associated protein 1
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PDIA4 protein disulfide isomerase family A, member 4
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1
PEX6 peroxisomal biogenesis factor 6
PHB prohibitin
PHB2 prohibitin 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLIN3 perilipin 3
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
PRDX4 peroxiredoxin 4
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKCSH protein kinase C substrate 80K-H
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF31 pre-mRNA processing factor 31
PRPF4 pre-mRNA processing factor 4
PRPF8 pre-mRNA processing factor 8
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTPRA protein tyrosine phosphatase, receptor type, A
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
RAB1A RAB1A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RABGGTA Rab geranylgeranyltransferase, alpha subunit
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANBP3 RAN binding protein 3
RERE arginine-glutamic acid dipeptide (RE) repeats
RING1 ring finger protein 1
RPA2 replication protein A2, 32kDa
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RUVBL2 RuvB-like AAA ATPase 2
SARS seryl-tRNA synthetase
SART3 squamous cell carcinoma antigen recognized by T cells 3
SCARB1 scavenger receptor class B, member 1
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SEC23IP SEC23 interacting protein
SEC31A SEC31 homolog A (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SEPT7 septin 7
SERP1 stress-associated endoplasmic reticulum protein 1
SFSWAP splicing factor, suppressor of white-apricot family
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2B1 SH2B adaptor protein 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMAD2 SMAD family member 2
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMC5 structural maintenance of chromosomes 5
SMNDC1 survival motor neuron domain containing 1
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae)
SPRN shadow of prion protein homolog (zebrafish)
SRRT serrate, RNA effector molecule
SS18 synovial sarcoma translocation, chromosome 18
SSB Sjogren syndrome antigen B (autoantigen La)
SSR1 signal sequence receptor, alpha
SSRP1 structure specific recognition protein 1
STARD7 StAR-related lipid transfer (START) domain containing 7
STK19 serine/threonine kinase 19
STX3 syntaxin 3
SUMO2 small ubiquitin-like modifier 2
SUMO4 small ubiquitin-like modifier 4
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBL2 transducin (beta)-like 2
TCEA1 transcription elongation factor A (SII), 1
TCOF1 Treacher Collins-Franceschetti syndrome 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX261 testis expressed 261
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TMED1 transmembrane emp24 protein transport domain containing 1
TOMM34 translocase of outer mitochondrial membrane 34
TP53BP1 tumor protein p53 binding protein 1
TPR translocated promoter region, nuclear basket protein
TRIM27 tripartite motif containing 27
TRIP13 thyroid hormone receptor interactor 13
TRRAP transformation/transcription domain-associated protein
TSTA3 tissue specific transplantation antigen P35B
TTI1 TELO2 interacting protein 1
TUBGCP2 tubulin, gamma complex associated protein 2
TXLNA taxilin alpha
UBE2A ubiquitin-conjugating enzyme E2A
UBE3C ubiquitin protein ligase E3C
UFD1L ubiquitin fusion degradation 1 like (yeast)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAMP3 vesicle-associated membrane protein 3
VARS valyl-tRNA synthetase
VGLL4 vestigial-like family member 4
WDR18 WD repeat domain 18
WDR62 WD repeat domain 62
XPO6 exportin 6
XPO7 exportin 7
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF271P zinc finger protein 271, pseudogene
ZNHIT3 zinc finger, HIT-type containing 3
ZPR1 ZPR1 zinc finger