DDR1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description discoidin domain receptor tyrosine kinase 1|Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] (NCBI Entrez Gene Database, 780)
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Genes

331 genes differentially expressed following the DDR1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PCDHA8 protocadherin alpha 8 4.00068
IGFL2 IGF-like family member 2 4.00068
NANOS2 nanos homolog 2 (Drosophila) 4.00068
TMEM176A transmembrane protein 176A 4.00068
TRIM17 tripartite motif containing 17 4.00068
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 4.00068
DSG3 desmoglein 3 4.00068
PAX8 paired box 8 4.00068
CEP295NL CEP295 N-terminal like 4.00068
SIGLEC7 sialic acid binding Ig-like lectin 7 4.00068
CDH5 cadherin 5, type 2 (vascular endothelium) 4.00068
PLEK pleckstrin 4.00068
SOX1 SRY (sex determining region Y)-box 1 4.00068
CD300LG CD300 molecule-like family member g 4.00068
TBX21 T-box 21 4.00068
CCDC116 coiled-coil domain containing 116 4.00068
TMPRSS11F transmembrane protease, serine 11F 4.00068
FAM187B family with sequence similarity 187, member B 4.00068
FAM90A26 family with sequence similarity 90, member A26, pseudogene 4.00068
RNF17 ring finger protein 17 4.00068
CST11 cystatin 11 4.00068
CD6 CD6 molecule 4.00068
ASB10 ankyrin repeat and SOCS box containing 10 4.00068
RPE65 retinal pigment epithelium-specific protein 65kDa 4.00068
BHMT2 betaine--homocysteine S-methyltransferase 2 4.00068
DIO3 deiodinase, iodothyronine, type III 4.00068
BMP5 bone morphogenetic protein 5 4.00068
WIZ widely interspaced zinc finger motifs 4.00068
ACY3 aminoacylase 3 4.00068
SPACA3 sperm acrosome associated 3 4.00068
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 4.00068
HES2 hes family bHLH transcription factor 2 4.00068
STEAP4 STEAP family member 4 4.00068
MMP20 matrix metallopeptidase 20 4.00068
LRRC61 leucine rich repeat containing 61 4.00068
S100A1 S100 calcium binding protein A1 4.00068
ADAMTSL5 ADAMTS-like 5 4.00068
GADL1 glutamate decarboxylase-like 1 4.00068
C1ORF141 chromosome 1 open reading frame 141 4.00068
TDRD9 tudor domain containing 9 4.00068
LRRC10B leucine rich repeat containing 10B 4.00068
KHDC3L KH domain containing 3-like, subcortical maternal complex member 4.00068
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 4.00068
CPB1 carboxypeptidase B1 (tissue) 4.00068
GMNC geminin coiled-coil domain containing 4.00068
TMEM132C transmembrane protein 132C 4.00068
KLHL33 kelch-like family member 33 4.00068
CATSPERH catsper channel auxiliary subunit eta 4.00068
H3-5 H3.5 histone 4.00068
STING1 stimulator of interferon response cGAMP interactor 1 4.00068
C3AR1 complement component 3a receptor 1 4.00068
YIPF7 Yip1 domain family, member 7 4.00068
ROPN1L rhophilin associated tail protein 1-like 4.00068
CLDN14 claudin 14 4.00068
TRAPPC3L trafficking protein particle complex 3-like 4.00068
MYH7 myosin, heavy chain 7, cardiac muscle, beta 4.00068
FIMP1 fertilization-influencing membrane protein 1 4.00068
CCDC9B coiled-coil domain containing 9B 4.00068
PLAAT4 phospholipase A and acyltransferase 4 4.00068
DIPK1C divergent protein kinase domain 1C 4.00068
TEKTL1 tektin like 1 4.00068
TEX53 testis expressed 53 4.00068
LOC124906010 uncharacterized LOC124906010 4.00068
LOC124902436 talanin 4.00068
SERTM2 serine rich and transmembrane domain containing 2 4.00068
LHFPL7 LHFPL tetraspan subfamily member 7 4.00068
CFAP299 cilia and flagella associated protein 299 4.00068
DNAAF6 dynein axonemal assembly factor 6 4.00068
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 4.00068
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 4.00068
IQCF3 IQ motif containing F3 4.00068
KLRF2 killer cell lectin-like receptor subfamily F, member 2 4.00068
TBX3 T-box 3 4.00068
PDE1B phosphodiesterase 1B, calmodulin-dependent 4.00068
NHLRC4 NHL repeat containing 4 4.00068
IL3 interleukin 3 4.00068
ZNF575 zinc finger protein 575 4.00068
LOC124901872 uncharacterized LOC124901872 4.00068
NXPE2 neurexophilin and PC-esterase domain family, member 2 4.00068
CLDN2 claudin 2 4.00068
PRR18 proline rich 18 4.00068
C7ORF57 chromosome 7 open reading frame 57 4.00068
CLEC17A C-type lectin domain family 17, member A 4.00068
ASB9 ankyrin repeat and SOCS box containing 9 4.00068
BDKRB1 bradykinin receptor B1 4.00068
XKR3 XK, Kell blood group complex subunit-related family, member 3 4.00068
IMPG1 interphotoreceptor matrix proteoglycan 1 4.00068
CLEC6A C-type lectin domain family 6, member A 4.00068
NPIPB8 nuclear pore complex interacting protein family, member B8 4.00068
GDF7 growth differentiation factor 7 4.00068
OOSP1 oocyte secreted protein 1, pseudogene 4.00068
LRRC3C leucine rich repeat containing 3C 4.00068
PCDHB11 protocadherin beta 11 4.00068
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 4.00068
RAB40AL RAB40A, member RAS oncogene family-like 4.00068
VAV1 vav 1 guanine nucleotide exchange factor 4.00068
NT5C1B 5'-nucleotidase, cytosolic IB 4.00068
PALMD palmdelphin 4.00068
EBF2 early B-cell factor 2 4.00068
GP1BB glycoprotein Ib (platelet), beta polypeptide 4.00068
APOH apolipoprotein H (beta-2-glycoprotein I) 4.00068
PHOSPHO1 phosphatase, orphan 1 4.00068
F13B coagulation factor XIII, B polypeptide 4.00068
MAGEB17 melanoma antigen family B17 4.00068
ANKRD62 ankyrin repeat domain 62 4.00068
AGR2 anterior gradient 2 4.00068
NCR3 natural cytotoxicity triggering receptor 3 4.00068
ACSM1 acyl-CoA synthetase medium-chain family member 1 4.00068
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 4.00068
FZD1 frizzled class receptor 1 4.00068
RGR retinal G protein coupled receptor 4.00068
EPO erythropoietin 4.00068
ZNF132 zinc finger protein 132 4.00068
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 4.00068
GSTA1 glutathione S-transferase alpha 1 4.00068
SMLR1 small leucine-rich protein 1 4.00068
SEC14L3 SEC14-like 3 (S. cerevisiae) 4.00068
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 4.00068
DRD2 dopamine receptor D2 4.00068
CATIP ciliogenesis associated TTC17 interacting protein 4.00068
ODF1 outer dense fiber of sperm tails 1 4.00068
POU2AF1 POU class 2 associating factor 1 4.00068
HKDC1 hexokinase domain containing 1 4.00068
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 4.00068
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 4.00068
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 4.00068
GOLGA6B golgin A6 family, member B 4.00068
PRR35 proline rich 35 4.00068
AQP5 aquaporin 5 4.00068
FGR FGR proto-oncogene, Src family tyrosine kinase 4.00068
CSTA cystatin A (stefin A) 4.00068
ITGB7 integrin, beta 7 4.00068
POTEF POTE ankyrin domain family, member F 4.00068
NMBR neuromedin B receptor 4.00068
FKBP1C FK506 binding protein 1C 4.00068
BTG4 B-cell translocation gene 4 4.00068
SIRPG signal-regulatory protein gamma 4.00068
OR6B1 olfactory receptor, family 6, subfamily B, member 1 4.00068
WNT10B wingless-type MMTV integration site family, member 10B 4.00068
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 4.00068
RP1 retinitis pigmentosa 1 (autosomal dominant) 4.00068
NRGN neurogranin (protein kinase C substrate, RC3) 4.00068
GPR150 G protein-coupled receptor 150 4.00068
OR51I2 olfactory receptor, family 51, subfamily I, member 2 4.00068
LPA lipoprotein, Lp(a) 4.00068
MMP13 matrix metallopeptidase 13 4.00068
GALP galanin-like peptide 4.00068
GOLGA8R golgin A8 family, member R 4.00068
FGF6 fibroblast growth factor 6 4.00068
FGF17 fibroblast growth factor 17 4.00068
SMCO3 single-pass membrane protein with coiled-coil domains 3 4.00068
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 4.00068
DHRS9 dehydrogenase/reductase (SDR family) member 9 4.00068
PDX1 pancreatic and duodenal homeobox 1 4.00068
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 4.00068
TPH1 tryptophan hydroxylase 1 4.00068
PHACTR3 phosphatase and actin regulator 3 4.00068
RERGL RERG/RAS-like 4.00068
OR14A2 olfactory receptor, family 14, subfamily A, member 2 4.00068
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.97657
KLK14 kallikrein-related peptidase 14 3.56548
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 3.30048
ADGRF3 adhesion G protein-coupled receptor F3 3.30048
DPH6 diphthamine biosynthesis 6 3.15785
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.01966
INSL6 insulin-like 6 3.01966
CA9 carbonic anhydrase IX 3.01966
TDRD1 tudor domain containing 1 3.01966
SRL sarcalumenin 3.01966
CATSPERD catsper channel auxiliary subunit delta 3.01966
RFTN2 raftlin family member 2 3.01878
SLITRK3 SLIT and NTRK-like family, member 3 2.90119
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 2.87851
MELTF melanotransferrin 2.81975
LIFR leukemia inhibitory factor receptor alpha 2.72496
DBF4 DBF4 zinc finger 2.7156
CCDC93 coiled-coil domain containing 93 2.70304
RUFY2 RUN and FYVE domain containing 2 2.62155
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.61863
MED17 mediator complex subunit 17 2.57932
TUFT1 tuftelin 1 2.54768
ELK1 ELK1, member of ETS oncogene family 2.50513
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3 2.491
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.47717
COA8 cytochrome c oxidase assembly factor 8 2.47717
MYH11 myosin, heavy chain 11, smooth muscle 2.46676
NOCT nocturnin 2.45056
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 2.43488
TGM1 transglutaminase 1 2.43488
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 2.38801
MMP9 matrix metallopeptidase 9 2.37715
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.32478
ZNF774 zinc finger protein 774 2.31166
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 2.3104
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.30792
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.2847
CDH22 cadherin 22, type 2 2.2847
TRIB1 tribbles pseudokinase 1 2.27123
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 2.26331
GPS1 G protein pathway suppressor 1 2.26295
JPT1 Jupiter microtubule associated homolog 1 2.24937
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 2.24904
KALRN kalirin, RhoGEF kinase 2.24563
SNX4 sorting nexin 4 2.24563
ABI3BP ABI family, member 3 (NESH) binding protein 2.24536
LHFPL2 lipoma HMGIC fusion partner-like 2 2.24536
ZMAT5 zinc finger, matrin-type 5 2.23888
RPN1 ribophorin I 2.22743
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 2.22441
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 2.20946
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.19509
ZC2HC1C zinc finger, C2HC-type containing 1C 2.16991
FEM1A fem-1 homolog a (C. elegans) 2.1675
DYNLT3 dynein, light chain, Tctex-type 3 2.16287
EID2 EP300 interacting inhibitor of differentiation 2 2.13754
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 2.13709
MYO1D myosin ID 2.12353
R3HDM2 R3H domain containing 2 2.09668
TADA3 transcriptional adaptor 3 2.09218
TMSB15C thymosin beta 15C 2.08002
CTTNBP2NL CTTNBP2 N-terminal like 2.0604
EIF6 eukaryotic translation initiation factor 6 2.03927
CMC1 C-x(9)-C motif containing 1 2.0191
CDCA7L cell division cycle associated 7-like 2.01893
MRPL24 mitochondrial ribosomal protein L24 2.01893
CDK1 cyclin-dependent kinase 1 2.01729
NAF1 nuclear assembly factor 1 ribonucleoprotein 2.01198
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.00792
IFI27L2 interferon, alpha-inducible protein 27-like 2 2.00792

decreased expression

Symbol Name Standardized Value
GHRL ghrelin/obestatin prepropeptide -4.00068
CD86 CD86 molecule -4.00068
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -4.00068
ZNF471 zinc finger protein 471 -4.00068
CARNS1 carnosine synthase 1 -3.97657
TMEM229A transmembrane protein 229A -3.97657
THSD8 thrombospondin type 1 domain containing 8 -3.97657
CDKN2A cyclin-dependent kinase inhibitor 2A -3.97657
CNTFR ciliary neurotrophic factor receptor -3.97657
ACBD5 acyl-CoA binding domain containing 5 -3.97657
SYTL4 synaptotagmin-like 4 -3.97657
UBA7 ubiquitin-like modifier activating enzyme 7 -3.97657
NLRP6 NLR family, pyrin domain containing 6 -3.97657
SFTPD surfactant protein D -3.97657
SERF1A small EDRK-rich factor 1A (telomeric) -3.97657
NR4A3 nuclear receptor subfamily 4, group A, member 3 -3.97657
GDNF glial cell derived neurotrophic factor -3.97657
MOGAT3 monoacylglycerol O-acyltransferase 3 -3.97657
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -3.97657
PARP3 poly (ADP-ribose) polymerase family, member 3 -3.97657
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -3.97657
HAL histidine ammonia-lyase -3.97657
GDF9 growth differentiation factor 9 -3.97657
VAX2 ventral anterior homeobox 2 -3.97657
THBD thrombomodulin -3.97657
ISL1 ISL LIM homeobox 1 -3.97657
SHISA8 shisa family member 8 -3.97657
H3C14 H3 clustered histone 14 -3.97657
FLACC1 flagellum associated containing coiled-coil domains 1 -3.97657
C20ORF204 chromosome 20 open reading frame 204 -3.97657
SVOP SV2 related protein homolog (rat) -3.97657
ITGA11 integrin, alpha 11 -3.97657
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -3.97657
H4C12 H4 clustered histone 12 -3.97657
TMEM40 transmembrane protein 40 -3.97657
NXPE1 neurexophilin and PC-esterase domain family, member 1 -3.97657
FAIM2 Fas apoptotic inhibitory molecule 2 -3.97657
ETV3L ets variant 3-like -3.97657
RGCC regulator of cell cycle -3.97657
CDC25A cell division cycle 25A -3.70088
ALDOC aldolase C, fructose-bisphosphate -3.2702
PHLDB1 pleckstrin homology-like domain, family B, member 1 -3.13653
ZNF154 zinc finger protein 154 -3.06707
SPTBN1 spectrin, beta, non-erythrocytic 1 -2.87918
EPS15 epidermal growth factor receptor pathway substrate 15 -2.83649
MIA3 melanoma inhibitory activity family, member 3 -2.83314
TMEM161B transmembrane protein 161B -2.79577
CLEC4C C-type lectin domain family 4, member C -2.78389
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H -2.78389
TCP11L2 t-complex 11, testis-specific-like 2 -2.64222
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -2.63341
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.60974
ANO2 anoctamin 2, calcium activated chloride channel -2.58107
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 -2.54923
TECPR2 tectonin beta-propeller repeat containing 2 -2.54768
CROCC ciliary rootlet coiled-coil, rootletin -2.53082
UNK unkempt family zinc finger -2.51376
BAG4 BCL2-associated athanogene 4 -2.43795
CNIH2 cornichon family AMPA receptor auxiliary protein 2 -2.39434
BTBD1 BTB (POZ) domain containing 1 -2.39434
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 -2.3921
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -2.36878
HRK harakiri, BCL2 interacting protein -2.32478
BABAM1 BRISC and BRCA1 A complex member 1 -2.3104
MBIP MAP3K12 binding inhibitory protein 1 -2.27418
ZNF221 zinc finger protein 221 -2.27123
BEST4 bestrophin 4 -2.27123
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.26331
FASTKD1 FAST kinase domains 1 -2.24563
ING1 inhibitor of growth family, member 1 -2.23923
TSGA10IP testis specific, 10 interacting protein -2.22384
CDKN3 cyclin-dependent kinase inhibitor 3 -2.22099
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.2163
RELT RELT tumor necrosis factor receptor -2.20946
RTBDN retbindin -2.20946
TGFBI transforming growth factor, beta-induced, 68kDa -2.2072
ACVR1B activin A receptor, type IB -2.2057
STARD3NL STARD3 N-terminal like -2.2057
UCK2 uridine-cytidine kinase 2 -2.2057
CCDC24 coiled-coil domain containing 24 -2.2057
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.2057
ATAD3A ATPase family, AAA domain containing 3A -2.19171
MAGEF1 melanoma antigen family F1 -2.15895
RRM2B ribonucleotide reductase M2 B (TP53 inducible) -2.15554
CD46 CD46 molecule, complement regulatory protein -2.14751
DPP9 dipeptidyl-peptidase 9 -2.1464
MRPL3 mitochondrial ribosomal protein L3 -2.145
ZNF358 zinc finger protein 358 -2.12353
SCN5A sodium channel, voltage gated, type V alpha subunit -2.11557
PISD phosphatidylserine decarboxylase -2.10168
SECISBP2 SECIS binding protein 2 -2.09668
SLC44A5 solute carrier family 44, member 5 -2.08647
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -2.04518
FAAP24 FA core complex associated protein 24 -2.03533
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.02875
STK32B serine/threonine kinase 32B -2.01729
CYB5R1 cytochrome b5 reductase 1 -2.00807
XPOT exportin, tRNA -2.00807
CD276 CD276 molecule -2.00807
MED21 mediator complex subunit 21 -2.00792
UBE2T ubiquitin-conjugating enzyme E2T -2.00715
CRELD2 cysteine-rich with EGF-like domains 2 -2.00413