DES Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description desmin|This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1674)
Similar Terms
Downloads & Tools

Genes

339 genes differentially expressed following the DES gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OXCT2 3-oxoacid CoA transferase 2 2.30299
LGALS9 lectin, galactoside-binding, soluble, 9 2.30299
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.30299
GLYCTK glycerate kinase 2.30299
CSTA cystatin A (stefin A) 2.30299
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.30299
ZNF784 zinc finger protein 784 2.30299
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.30299
C2CD4D C2 calcium-dependent domain containing 4D 2.30299
ZNF597 zinc finger protein 597 2.30299
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.30299
LHX6 LIM homeobox 6 2.30299
ANKRD34A ankyrin repeat domain 34A 2.30299
TUBB1 tubulin, beta 1 class VI 2.30299
OXER1 oxoeicosanoid (OXE) receptor 1 2.30299
MBLAC1 metallo-beta-lactamase domain containing 1 2.30299
CETP cholesteryl ester transfer protein, plasma 2.30299
VWA5B2 von Willebrand factor A domain containing 5B2 2.30299
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 2.30299
ASB2 ankyrin repeat and SOCS box containing 2 2.30299
DEUP1 deuterosome assembly protein 1 2.30299
CIMAP2 ciliary microtubule associated protein 2 2.30299
SMTNL2 smoothelin-like 2 2.30299
SLC67A1 solute carrier family 67 member 1 2.30299
GBA1 glucosylceramidase beta 1 2.30299
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.30299
PCDHB6 protocadherin beta 6 2.26508
WNT3A wingless-type MMTV integration site family, member 3A 2.26508
SMIM31 small integral membrane protein 31 2.26508
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.26508
RAX retina and anterior neural fold homeobox 2.26508
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.26508
CD1D CD1d molecule 2.26508
CD1C CD1c molecule 2.26508
RNF17 ring finger protein 17 2.26508
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.26508
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.26508
SELPLG selectin P ligand 2.26508
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 2.26508
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.26508
GLYATL1B glycine-N-acyltransferase like 1B 2.26508
H3C3 H3 clustered histone 3 2.26508
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.26508
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.26508
MINDY4B MINDY family member 4B 2.26508
ZDHHC5 zinc finger, DHHC-type containing 5 2.26508
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 2.26508
C1ORF141 chromosome 1 open reading frame 141 2.26508
TDRD9 tudor domain containing 9 2.26508
TMEM74 transmembrane protein 74 2.26508
CRIP1 cysteine-rich protein 1 (intestinal) 2.26508
NPIPA7 nuclear pore complex interacting protein family, member A7 2.26508
BRICD5 BRICHOS domain containing 5 2.26508
CRYGN crystallin, gamma N 2.26508
ACOT12 acyl-CoA thioesterase 12 2.26508
CORO6 coronin 6 2.26508
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.26508
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.26508
SCRG1 stimulator of chondrogenesis 1 2.26508
SLC25A41 solute carrier family 25, member 41 2.26508
MEI1 meiosis inhibitor 1 2.26508
TMSB15C thymosin beta 15C 2.26508
MSN moesin 2.26508
DNAAF19 dynein axonemal assembly factor 19 2.26508
FAM221B family with sequence similarity 221, member B 2.26508
RAPSN receptor-associated protein of the synapse 2.26508
NCKAP1L NCK-associated protein 1-like 2.26508
GSG1 germ cell associated 1 2.26508
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 2.26508
ALX3 ALX homeobox 3 2.26508
OSTN osteocrin 2.26508
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.26508
MMD2 monocyte to macrophage differentiation-associated 2 2.26508
COX8C cytochrome c oxidase subunit VIIIC 2.26508
LRRC72 leucine rich repeat containing 72 2.26508
DDTL D-dopachrome tautomerase-like 2.26508
UTS2 urotensin 2 2.26508
TSPO2 translocator protein 2 2.26508
BARX1 BARX homeobox 1 2.26508
H1-6 H1.6 linker histone, cluster member 2.26508
MAGIX MAGI family member, X-linked 2.26508
SMTNL1 smoothelin-like 1 2.26508
RHCG Rh family, C glycoprotein 2.26508
RD3 retinal degeneration 3 2.26508
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.26508
ACSL5 acyl-CoA synthetase long-chain family member 5 2.26508
TMEM40 transmembrane protein 40 2.26508
VWA3B von Willebrand factor A domain containing 3B 2.26508
GRAP GRB2-related adaptor protein 2.26508
POMC proopiomelanocortin 2.26508
PRRC1 proline-rich coiled-coil 1 2.26508
TACR2 tachykinin receptor 2 2.26508
CCR9 chemokine (C-C motif) receptor 9 2.26508
ISM2 isthmin 2 2.26508
PVRIG poliovirus receptor related immunoglobulin domain containing 2.26508
MAJIN membrane anchored junction protein 2.26508
FAM153A family with sequence similarity 153, member A 2.26508
SCARA5 scavenger receptor class A, member 5 2.26508
PIGX phosphatidylinositol glycan anchor biosynthesis, class X 2.26508
LOX lysyl oxidase 2.26508
SIX3 SIX homeobox 3 2.26508
TMEM212 transmembrane protein 212 2.26508
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.26508
PYDC1 PYD (pyrin domain) containing 1 2.26508
THPO thrombopoietin 2.26508
SPDYC speedy/RINGO cell cycle regulator family member C 2.26508
CCDC9B coiled-coil domain containing 9B 2.26508
SMIM41 small integral membrane protein 41 2.26508
ESR1 estrogen receptor 1 2.26508
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.26508
DNAI7 dynein axonemal intermediate chain 7 2.26508
TMEM235 transmembrane protein 235 2.26508
GAS6 growth arrest-specific 6 2.26508
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.26508
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 2.26508
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 2.26508
UNC93B1 unc-93 homolog B1 (C. elegans) 2.26508
RAD51AP2 RAD51 associated protein 2 2.26508
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 2.26508
CDHR4 cadherin-related family member 4 2.26508
ITSN1 intersectin 1 (SH3 domain protein) 2.26508
CKAP2 cytoskeleton associated protein 2 2.26508
MAB21L2 mab-21-like 2 (C. elegans) 2.26508
POU2AF1 POU class 2 associating factor 1 2.26508
KIF3C kinesin family member 3C 2.26508
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.26508
LMOD2 leiomodin 2 (cardiac) 2.26508
CDC20B cell division cycle 20B 2.26508
CLDN34 claudin 34 2.26508
ALAS2 5'-aminolevulinate synthase 2 2.26508
PDCL2 phosducin-like 2 2.26508
MYF5 myogenic factor 5 2.26508
ARHGAP20 Rho GTPase activating protein 20 2.26508
MRLN myoregulin 2.26508
PHLDA1 pleckstrin homology-like domain, family A, member 1 2.26508
RAB40C RAB40C, member RAS oncogene family 2.26508
TTLL12 tubulin tyrosine ligase-like family member 12 2.26508
EDN1 endothelin 1 2.26508
EXTL1 exostosin-like glycosyltransferase 1 2.26508
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2.26508
IL19 interleukin 19 2.26508
ZNF843 zinc finger protein 843 2.26508
EFCAB12 EF-hand calcium binding domain 12 2.26508
MSMP microseminoprotein, prostate associated 2.26508
ERVV-2 endogenous retrovirus group V, member 2 2.26508
RASA4 RAS p21 protein activator 4 2.26508
IL25 interleukin 25 2.26508
AOC2 amine oxidase, copper containing 2 (retina-specific) 2.26508
ADAM12 ADAM metallopeptidase domain 12 2.26508
WNT4 wingless-type MMTV integration site family, member 4 2.26508
SORBS2 sorbin and SH3 domain containing 2 2.26508
ZNF836 zinc finger protein 836 2.26508
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.26508
EFCC1 EF-hand and coiled-coil domain containing 1 2.26508
ITGB7 integrin, beta 7 2.26508
RIPPLY2 ripply transcriptional repressor 2 2.26508
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.26508
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.26508
OTOP1 otopetrin 1 2.26508
INSM1 insulinoma-associated 1 2.26508
PRTN3 proteinase 3 2.26508
SLC38A8 solute carrier family 38, member 8 2.26508
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.26508
CD24 CD24 molecule 2.26508
UPK1A uroplakin 1A 2.26508
LRRC36 leucine rich repeat containing 36 2.26508
ERAP2 endoplasmic reticulum aminopeptidase 2 2.26508
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.26508
ASGR2 asialoglycoprotein receptor 2 2.26508
PADI6 peptidyl arginine deiminase, type VI 2.26508
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.26508
MRC1 mannose receptor, C type 1 2.26508
RBP4 retinol binding protein 4, plasma 2.26508
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.26508
SNTN sentan, cilia apical structure protein 2.26508
CHRDL2 chordin-like 2 2.26508
RAB7B RAB7B, member RAS oncogene family 2.26508
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.26508
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.26508
PCDHGA11 protocadherin gamma subfamily A, 11 2.26508
WAS Wiskott-Aldrich syndrome 2.26508
METTL21C methyltransferase like 21C 2.26508
TOR2A torsin family 2, member A 2.26508
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.26508
LEP leptin 2.26508
ZFR zinc finger RNA binding protein 2.26508
CENPM centromere protein M 2.26508
CD226 CD226 molecule 2.26508
CD86 CD86 molecule 2.26508
TRPM1 transient receptor potential cation channel, subfamily M, member 1 2.26508
FGF16 fibroblast growth factor 16 2.26508
CHRM1 cholinergic receptor, muscarinic 1 2.26508
MYO1A myosin IA 2.26508
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.26508
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.26508
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 2.26508
PRSS53 protease, serine, 53 2.26508
PRSS56 protease, serine, 56 2.26508
MAGEB17 melanoma antigen family B17 2.26508
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.26508
LAMP3 lysosomal-associated membrane protein 3 2.26508
EPN3 epsin 3 2.26508
BEX3 brain expressed X-linked 3 2.24671
MTG1 mitochondrial ribosome-associated GTPase 1 2.24642
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 2.24324
SALL4 spalt-like transcription factor 4 2.23164
ZNF500 zinc finger protein 500 2.18057
TMSB4X thymosin beta 4, X-linked 2.1755
MTIF3 mitochondrial translational initiation factor 3 2.17185
TTI2 TELO2 interacting protein 2 2.14523
ZNF775 zinc finger protein 775 2.13528
PREP prolyl endopeptidase 2.1338
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 2.11883
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.11547
ZNF256 zinc finger protein 256 2.10702
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.09112
KCP kielin/chordin-like protein 2.08503
MRPS18A mitochondrial ribosomal protein S18A 2.08503
NOS3 nitric oxide synthase 3 (endothelial cell) 2.08503
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.08307
SPATA24 spermatogenesis associated 24 2.08185
CLN5 ceroid-lipofuscinosis, neuronal 5 2.06624
RAVER2 ribonucleoprotein, PTB-binding 2 2.06566
CLHC1 clathrin heavy chain linker domain containing 1 2.0656
GCLM glutamate-cysteine ligase, modifier subunit 2.05952
USP9X ubiquitin specific peptidase 9, X-linked 2.05344
SRP19 signal recognition particle 19kDa 2.05344
MAP2K5-DT MAP2K5 divergent transcript 2.04734
MYRIP myosin VIIA and Rab interacting protein 2.03394
SYBU syntabulin (syntaxin-interacting) 2.01599
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.00971
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae) 2.00919
CAB39 calcium binding protein 39 2.00249

decreased expression

Symbol Name Standardized Value
ALG10 ALG10, alpha-1,2-glucosyltransferase -2.30299
SP2 Sp2 transcription factor -2.30299
ZMYM1 zinc finger, MYM-type 1 -2.30299
KLHL17 kelch-like family member 17 -2.30299
TMBIM1 transmembrane BAX inhibitor motif containing 1 -2.30299
DIO1 deiodinase, iodothyronine, type I -2.26508
DIO2 deiodinase, iodothyronine, type II -2.26508
MOGAT3 monoacylglycerol O-acyltransferase 3 -2.26508
RGPD1 RANBP2-like and GRIP domain containing 1 -2.26508
JDP2 Jun dimerization protein 2 -2.26508
DRP2 dystrophin related protein 2 -2.26508
REPS1 RALBP1 associated Eps domain containing 1 -2.26508
MYL7 myosin, light chain 7, regulatory -2.26508
NMUR1 neuromedin U receptor 1 -2.26508
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -2.26508
CYSRT1 cysteine-rich tail protein 1 -2.26508
GRM1 glutamate receptor, metabotropic 1 -2.26508
FXYD5 FXYD domain containing ion transport regulator 5 -2.26508
KAT2B K(lysine) acetyltransferase 2B -2.26508
NUMB numb homolog (Drosophila) -2.26508
C11ORF86 chromosome 11 open reading frame 86 -2.26508
MID2 midline 2 -2.26508
CC2D2B coiled-coil and C2 domain containing 2B -2.26508
MARCHF9 membrane associated ring-CH-type finger 9 -2.26508
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.26508
FMC1 formation of mitochondrial complex V assembly factor 1 homolog -2.26508
RUSF1 RUS family member 1 -2.26508
NFIA nuclear factor I/A -2.26508
TUBGCP3 tubulin, gamma complex associated protein 3 -2.26508
CATSPERB catsper channel auxiliary subunit beta -2.26508
RBM44 RNA binding motif protein 44 -2.26508
TMEM234 transmembrane protein 234 -2.26508
LINC02983 long intergenic non-protein coding RNA 2983 -2.26508
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 -2.26508
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.26508
ADCK5 aarF domain containing kinase 5 -2.26508
LSM1 LSM1, U6 small nuclear RNA associated -2.26508
PDLIM2 PDZ and LIM domain 2 (mystique) -2.26508
OSBPL7 oxysterol binding protein-like 7 -2.26508
CFAP90 cilia and flagella associated protein 90 -2.26508
OCIAD2 OCIA domain containing 2 -2.26508
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -2.26508
SMAD2 SMAD family member 2 -2.26508
SPATA13 spermatogenesis associated 13 -2.26508
OR56A4 olfactory receptor, family 56, subfamily A, member 4 -2.26508
MOK MOK protein kinase -2.26508
LHX8 LIM homeobox 8 -2.26508
KLF5 Kruppel-like factor 5 (intestinal) -2.26508
LHFPL5 lipoma HMGIC fusion partner-like 5 -2.26508
OCA2 oculocutaneous albinism II -2.26508
PROS1 protein S (alpha) -2.26508
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.26508
SCT secretin -2.26508
BAHCC1 BAH domain and coiled-coil containing 1 -2.26508
CCDC183 coiled-coil domain containing 183 -2.26508
GLT8D1 glycosyltransferase 8 domain containing 1 -2.26508
CABP1 calcium binding protein 1 -2.26508
TMPRSS13 transmembrane protease, serine 13 -2.26508
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 -2.26508
SYT4 synaptotagmin IV -2.26508
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -2.26508
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -2.26508
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.26508
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.26508
EBF1 early B-cell factor 1 -2.26508
NUTM2F NUT family member 2F -2.26508
CCNA1 cyclin A1 -2.26508
CSPG4 chondroitin sulfate proteoglycan 4 -2.26508
AZIN2 antizyme inhibitor 2 -2.26508
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.26508
BNC2 basonuclin 2 -2.25639
CHD9 chromodomain helicase DNA binding protein 9 -2.2543
TMEM114 transmembrane protein 114 -2.24595
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.23842
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.23704
SERHL2 serine hydrolase-like 2 -2.23479
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -2.23273
SNX24 sorting nexin 24 -2.21195
FAM13A family with sequence similarity 13, member A -2.19494
ZNF800 zinc finger protein 800 -2.18437
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -2.18337
DNER delta/notch-like EGF repeat containing -2.15962
ERBB4 erb-b2 receptor tyrosine kinase 4 -2.15962
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 -2.14224
NCEH1 neutral cholesterol ester hydrolase 1 -2.13528
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -2.12897
MAMDC2 MAM domain containing 2 -2.12517
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.12352
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.11171
ARHGAP17 Rho GTPase activating protein 17 -2.08185
SH3GL3 SH3-domain GRB2-like 3 -2.07804
TBC1D16 TBC1 domain family, member 16 -2.07804
EWSR1 EWS RNA-binding protein 1 -2.07804
CUL2 cullin 2 -2.06624
GOLGA7 golgin A7 -2.06624
MGARP mitochondria-localized glutamic acid-rich protein -2.05344
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.05344
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.05344
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.05344
ZNF624 zinc finger protein 624 -2.05344
ZIC1 Zic family member 1 -2.05344
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.05344
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -2.04461
LRRC58 leucine rich repeat containing 58 -2.03279
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.00971
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -2.00971