DFFA Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description DNA fragmentation factor, 45kDa, alpha polypeptide|Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1676)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_DFFA
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Genes

128 co-expressed genes for DFFA from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ACTR6 ARP6 actin-related protein 6 homolog (yeast)
ANKRD17 ankyrin repeat domain 17
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL5A ADP-ribosylation factor-like 5A
ARMC8 armadillo repeat containing 8
ASB3 ankyrin repeat and SOCS box containing 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L1 BCL2-like 1
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRPF3 bromodomain and PHD finger containing, 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C14ORF1 chromosome 14 open reading frame 1
C1ORF52 chromosome 1 open reading frame 52
C2CD3 C2 calcium-dependent domain containing 3
C2CD5 C2 calcium-dependent domain containing 5
CAND1 cullin-associated and neddylation-dissociated 1
CCDC82 coiled-coil domain containing 82
CELF1 CUGBP, Elav-like family member 1
CEP76 centrosomal protein 76kDa
CHTOP chromatin target of PRMT1
CIZ1 CDKN1A interacting zinc finger protein 1
CLK4 CDC-like kinase 4
CNOT7 CCR4-NOT transcription complex, subunit 7
COMMD9 COMM domain containing 9
CRNKL1 crooked neck pre-mRNA splicing factor 1
CS citrate synthase
CSDE1 cold shock domain containing E1, RNA-binding
CTDNEP1 CTD nuclear envelope phosphatase 1
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36
DMTF1 cyclin D binding myb-like transcription factor 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
EPC2 enhancer of polycomb homolog 2 (Drosophila)
EPM2AIP1 EPM2A (laforin) interacting protein 1
EXOC5 exocyst complex component 5
FAM168B family with sequence similarity 168, member B
FAM8A1 family with sequence similarity 8, member A1
FBRSL1 fibrosin-like 1
FBXO30 F-box protein 30
GTPBP1 GTP binding protein 1
HEATR5B HEAT repeat containing 5B
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU-AS1 HNRNPU antisense RNA 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IPO5 importin 5
IPO9 importin 9
ISCA1 iron-sulfur cluster assembly 1
KANK2 KN motif and ankyrin repeat domains 2
KAT7 K(lysine) acetyltransferase 7
KDM3B lysine (K)-specific demethylase 3B
KIAA0430 KIAA0430
KIAA0907 KIAA0907
KLHL42 kelch-like family member 42
KMT2A lysine (K)-specific methyltransferase 2A
KPNA3 karyopherin alpha 3 (importin alpha 4)
LARS leucyl-tRNA synthetase
LEMD3 LEM domain containing 3
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
MEX3C mex-3 RNA binding family member C
MTMR1 myotubularin related protein 1
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NCOA5 nuclear receptor coactivator 5
NFYA nuclear transcription factor Y, alpha
NGRN neugrin, neurite outgrowth associated
NUP133 nucleoporin 133kDa
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1
PA2G4 proliferation-associated 2G4, 38kDa
PDCL phosducin-like
PFAS phosphoribosylformylglycinamidine synthase
PHF2 PHD finger protein 2
POGZ pogo transposable element with ZNF domain
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRPF8 pre-mRNA processing factor 8
PRRC2B proline-rich coiled-coil 2B
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RAN RAN, member RAS oncogene family
RBM17 RNA binding motif protein 17
RBM25 RNA binding motif protein 25
RBM8A RNA binding motif protein 8A
RBPJ recombination signal binding protein for immunoglobulin kappa J region
REPS1 RALBP1 associated Eps domain containing 1
RMDN3 regulator of microtubule dynamics 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPL7L1 ribosomal protein L7-like 1
RTCA RNA 3'-terminal phosphate cyclase
SCARB2 scavenger receptor class B, member 2
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33
SMAD2 SMAD family member 2
SMC3 structural maintenance of chromosomes 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPAST spastin
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TARDBP TAR DNA binding protein
TBC1D10B TBC1 domain family, member 10B
TCERG1 transcription elongation regulator 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAPPC6B trafficking protein particle complex 6B
TUBGCP3 tubulin, gamma complex associated protein 3
UBA2 ubiquitin-like modifier activating enzyme 2
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UFSP2 UFM1-specific peptidase 2
USP19 ubiquitin specific peptidase 19
USP33 ubiquitin specific peptidase 33
VEZF1 vascular endothelial zinc finger 1
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WDR70 WD repeat domain 70
YME1L1 YME1-like 1 ATPase
ZBED1 zinc finger, BED-type containing 1
ZBTB33 zinc finger and BTB domain containing 33
ZFAND5 zinc finger, AN1-type domain 5
ZFP62 ZFP62 zinc finger protein
ZMYM2 zinc finger, MYM-type 2
ZNF384 zinc finger protein 384
ZNF512 zinc finger protein 512
ZNF529 zinc finger protein 529
ZNF655 zinc finger protein 655