DGCR8 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description DGCR8 microprocessor complex subunit|This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 54487)
External Link http://www.ncbi.nlm.nih.gov/gene/54487
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Genes

59 interacting proteins for DGCR8 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
APP amyloid beta (A4) precursor protein
BCLAF1 BCL2-associated transcription factor 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
C1ORF35 chromosome 1 open reading frame 35
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
CUL3 cullin 3
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DROSHA drosha, ribonuclease type III
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF4A3 eukaryotic translation initiation factor 4A3
ERH enhancer of rudimentary homolog (Drosophila)
FLII flightless I homolog (Drosophila)
FUS FUS RNA binding protein
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
ILF3 interleukin enhancer binding factor 3, 90kDa
KHSRP KH-type splicing regulatory protein
LUC7L LUC7-like (S. cerevisiae)
LUC7L2 LUC7-like 2 (S. cerevisiae)
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MAPK1 mitogen-activated protein kinase 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
NAT10 N-acetyltransferase 10 (GCN5-related)
NUCLEOLIN nucleolin multifunctional protein
PABPC1 poly(A) binding protein, cytoplasmic 1
PCBP1 poly(rC) binding protein 1
PLEK2 pleckstrin 2
PNN pinin, desmosome associated protein
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRMT1 protein arginine methyltransferase 1
PRPF4 pre-mRNA processing factor 4
PYCRL pyrroline-5-carboxylate reductase-like
RAE1 ribonucleic acid export 1
RBM39 RNA binding motif protein 39
RBM8A RNA binding motif protein 8A
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SON SON DNA binding protein
SRPK1 SRSF protein kinase 1
SRPK2 SRSF protein kinase 2
SRPK3 SRSF protein kinase 3
SRRM2 serine/arginine repetitive matrix 2
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
SRSF8 serine/arginine-rich splicing factor 8
THRAP3 thyroid hormone receptor associated protein 3
TP53 tumor protein p53
U2AF1 U2 small nuclear RNA auxiliary factor 1
YAP1 Yes-associated protein 1
YTHDC1 YTH domain containing 1