DIABLO Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description diablo, IAP-binding mitochondrial protein|This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 56616)
External Link http://www.ncbi.nlm.nih.gov/gene/56616
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Genes

87 interacting proteins for DIABLO from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ANKRD13A ankyrin repeat domain 13A
AP1B1 adaptor-related protein complex 1, beta 1 subunit
APAF1 apoptotic peptidase activating factor 1
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARNT aryl hydrocarbon receptor nuclear translocator
BAG6 BCL2-associated athanogene 6
BAK1 BCL2-antagonist/killer 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BIRC7 baculoviral IAP repeat containing 7
BIRC8 baculoviral IAP repeat containing 8
CACYBP calcyclin binding protein
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDC40 cell division cycle 40
COX4I1 cytochrome c oxidase subunit IV isoform 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYLD cylindromatosis (turban tumor syndrome)
DNM1L dynamin 1-like
DZIP3 DAZ interacting zinc finger protein 3
E2F1 E2F transcription factor 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
ELAVL1 ELAV like RNA binding protein 1
FAF2 Fas associated factor family member 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GMPPB GDP-mannose pyrophosphorylase B
GOLGA3 golgin A3
GSK3B glycogen synthase kinase 3 beta
HLA-B major histocompatibility complex, class I, B
HNF4A hepatocyte nuclear factor 4, alpha
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTRA2 HtrA serine peptidase 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
ITCH itchy E3 ubiquitin protein ligase
KCTD10 potassium channel tetramerization domain containing 10
KCTD3 potassium channel tetramerization domain containing 3
LIMCH1 LIM and calponin homology domains 1
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAGED1 melanoma antigen family D1
MALT1 MALT1 paracaspase
MAML2 mastermind-like 2 (Drosophila)
MAX MYC associated factor X
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAIP NLR family, apoptosis inhibitory protein
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5DC2 5'-nucleotidase domain containing 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PEG10 paternally expressed 10
PRKCD protein kinase C, delta
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RLIM ring finger protein, LIM domain interacting
RNF31 ring finger protein 31
SLC25A47 solute carrier family 25, member 47
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SSRP1 structure specific recognition protein 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TCAF1 TRPM8 channel-associated factor 1
TMEM11 transmembrane protein 11
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TOLLIP toll interacting protein
TOM1L1 target of myb1 (chicken)-like 1
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TRAF3 TNF receptor-associated factor 3
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBC ubiquitin C
UBE2K ubiquitin-conjugating enzyme E2K
UBL4A ubiquitin-like 4A
UFD1L ubiquitin fusion degradation 1 like (yeast)
UFM1 ubiquitin-fold modifier 1
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WRNIP1 Werner helicase interacting protein 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF746 zinc finger protein 746