DLX5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description distal-less homeobox 5|This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1749)
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Genes

346 genes differentially expressed following the DLX5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.5559
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.5559
IL17B interleukin 17B 2.5559
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.5559
VWA7 von Willebrand factor A domain containing 7 2.5559
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.5559
GJB1 gap junction protein, beta 1, 32kDa 2.5559
MUC1 mucin 1, cell surface associated 2.5559
SDC2 syndecan 2 2.5559
CD300LF CD300 molecule-like family member f 2.5559
NPFFR1 neuropeptide FF receptor 1 2.5559
CALHM3 calcium homeostasis modulator 3 2.5559
SMYD1 SET and MYND domain containing 1 2.5559
COL11A2 collagen, type XI, alpha 2 2.5559
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.5559
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.5559
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.5559
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.5559
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.5559
CRYBB3 crystallin, beta B3 2.5559
PARP15 poly (ADP-ribose) polymerase family, member 15 2.5559
CENPF centromere protein F, 350/400kDa 2.5559
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.5559
SNPH syntaphilin 2.5559
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.5559
OXT oxytocin/neurophysin I prepropeptide 2.5559
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.5559
VXN vexin 2.5559
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.5559
CRYGN crystallin, gamma N 2.5559
PTGFR prostaglandin F receptor (FP) 2.5559
KLK6 kallikrein-related peptidase 6 2.5559
PLA2G12B phospholipase A2, group XIIB 2.5559
BHLHA15 basic helix-loop-helix family, member a15 2.5559
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.51533
DYNLT2B dynein light chain Tctex-type 2B 2.36967
PSAT1 phosphoserine aminotransferase 1 2.35144
RFPL3 ret finger protein-like 3 2.34453
MYBPHL myosin binding protein H-like 2.34453
GJA4 gap junction protein, alpha 4, 37kDa 2.34453
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.34453
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 2.34453
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 2.34453
KLHL31 kelch-like family member 31 2.34453
USP54 ubiquitin specific peptidase 54 2.34453
PTGDR2 prostaglandin D2 receptor 2 2.34453
APOOL apolipoprotein O-like 2.34453
SCG2 secretogranin II 2.34453
MPEG1 macrophage expressed 1 2.34453
SIGLEC9 sialic acid binding Ig-like lectin 9 2.34453
ASB12 ankyrin repeat and SOCS box containing 12 2.34453
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.34453
OLFM4 olfactomedin 4 2.34453
CLEC19A C-type lectin domain family 19, member A 2.34453
NOD2 nucleotide-binding oligomerization domain containing 2 2.34453
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.34453
KRT23 keratin 23, type I 2.34453
RPE65 retinal pigment epithelium-specific protein 65kDa 2.34453
NCF4 neutrophil cytosolic factor 4, 40kDa 2.34453
TAL1 T-cell acute lymphocytic leukemia 1 2.34453
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 2.34453
WNT3A wingless-type MMTV integration site family, member 3A 2.34453
PDYN prodynorphin 2.34453
FETUB fetuin B 2.34453
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.34453
IGFL4 IGF-like family member 4 2.34453
OLIG1 oligodendrocyte transcription factor 1 2.34453
ZSWIM2 zinc finger, SWIM-type containing 2 2.34453
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.34453
RAG1 recombination activating gene 1 2.34453
OPRM1 opioid receptor, mu 1 2.34453
GPX5 glutathione peroxidase 5 2.34453
LTB4R2 leukotriene B4 receptor 2 2.34453
SCEL sciellin 2.34453
PNLIPRP2 pancreatic lipase-related protein 2 2.34453
PNLIPRP1 pancreatic lipase-related protein 1 2.34453
MYH7 myosin, heavy chain 7, cardiac muscle, beta 2.34453
VN1R2 vomeronasal 1 receptor 2 2.34453
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 2.34453
ZAR1 zygote arrest 1 2.34453
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 2.34453
CIMIP2A ciliary microtubule inner protein 2A 2.34453
CIMIP7 ciliary microtubule inner protein 7 2.34453
LY6S-AS1 LY6S antisense RNA 1 2.34453
RHEX regulator of hemoglobinization and erythroid cell expansion 2.34453
GLYATL1B glycine-N-acyltransferase like 1B 2.34453
CFAP107 cilia and flagella associated protein 107 2.34453
ERFE erythroferrone 2.34453
CLXN calaxin 2.34453
TCEAL9 transcription elongation factor A like 9 2.34453
FAM237B family with sequence similarity 237 member B 2.34453
C9ORF43 chromosome 9 open reading frame 43 2.34453
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.34453
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.34453
LTF lactotransferrin 2.34453
IL16 interleukin 16 2.34453
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.34453
CDKN2A cyclin-dependent kinase inhibitor 2A 2.34453
EXOC3L4 exocyst complex component 3-like 4 2.34453
RNF26 ring finger protein 26 2.34453
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.34453
FAP fibroblast activation protein, alpha 2.34453
SLAMF8 SLAM family member 8 2.34453
MIA melanoma inhibitory activity 2.34453
PRDM7 PR domain containing 7 2.34453
GATA5 GATA binding protein 5 2.34453
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.34453
TFF2 trefoil factor 2 2.34453
TRIM31 tripartite motif containing 31 2.34453
NBPF15 neuroblastoma breakpoint family, member 15 2.34453
ASB4 ankyrin repeat and SOCS box containing 4 2.34453
FCMR Fc fragment of IgM receptor 2.34453
TSPAN1 tetraspanin 1 2.34453
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.34453
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.34453
GATA3 GATA binding protein 3 2.34453
OLAH oleoyl-ACP hydrolase 2.34453
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.34453
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.34453
CTNNA3 catenin (cadherin-associated protein), alpha 3 2.34453
KLF2 Kruppel-like factor 2 2.34453
PLET1 placenta expressed transcript 1 2.34453
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.34453
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.34453
TRIM55 tripartite motif containing 55 2.34453
TBXA2R thromboxane A2 receptor 2.34453
CAGE1 cancer antigen 1 2.34453
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.34453
KRTAP5-10 keratin associated protein 5-10 2.34453
PGR progesterone receptor 2.34453
SLC25A52 solute carrier family 25, member 52 2.34453
ACKR2 atypical chemokine receptor 2 2.34453
C9ORF50 chromosome 9 open reading frame 50 2.34453
PRAM1 PML-RARA regulated adaptor molecule 1 2.34453
ECM1 extracellular matrix protein 1 2.34453
SLFN12L schlafen family member 12-like 2.34453
LRRC32 leucine rich repeat containing 32 2.34453
MORC1 MORC family CW-type zinc finger 1 2.34453
AGXT2 alanine--glyoxylate aminotransferase 2 2.34453
ALOXE3 arachidonate lipoxygenase 3 2.34453
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.34453
CYTH4 cytohesin 4 2.34453
TYR tyrosinase 2.34453
ZNF213 zinc finger protein 213 2.34453
LAMB3 laminin, beta 3 2.34453
ETV3L ets variant 3-like 2.34453
PLA2G5 phospholipase A2, group V 2.34453
C22ORF31 chromosome 22 open reading frame 31 2.34453
TMEM255A transmembrane protein 255A 2.34453
CA5A carbonic anhydrase VA, mitochondrial 2.34453
CTSE cathepsin E 2.34453
DLX3 distal-less homeobox 3 2.34453
ART1 ADP-ribosyltransferase 1 2.34453
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.34453
TUG1 taurine up-regulated 1 (non-protein coding) 2.34453
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.34453
VSTM1 V-set and transmembrane domain containing 1 2.34453
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.34453
PDCD1LG2 programmed cell death 1 ligand 2 2.34453
FCRL2 Fc receptor-like 2 2.34453
NPC1 Niemann-Pick disease, type C1 2.34453
ZNF391 zinc finger protein 391 2.34453
TWIST1 twist family bHLH transcription factor 1 2.34453
AREG amphiregulin 2.34453
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.34453
C5ORF46 chromosome 5 open reading frame 46 2.34453
NLRP3 NLR family, pyrin domain containing 3 2.34453
LPA lipoprotein, Lp(a) 2.34453
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.34453
EBI3 Epstein-Barr virus induced 3 2.34453
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.34453
KRTAP5-2 keratin associated protein 5-2 2.34453
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.34453
DRGX dorsal root ganglia homeobox 2.34453
TBATA thymus, brain and testes associated 2.34453
KRT72 keratin 72, type II 2.34453
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.34453
VSX1 visual system homeobox 1 2.34453
BMP5 bone morphogenetic protein 5 2.34453
CLEC14A C-type lectin domain family 14, member A 2.34453
SPACA5 sperm acrosome associated 5 2.34453
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.34453
IFITM10 interferon induced transmembrane protein 10 2.34453
TAS2R43 taste receptor, type 2, member 43 2.34453
PLGLB2 plasminogen-like B2 2.34453
COL22A1 collagen, type XXII, alpha 1 2.34453
ZPLD1 zona pellucida-like domain containing 1 2.34453
SLITRK1 SLIT and NTRK-like family, member 1 2.34453
FGF10 fibroblast growth factor 10 2.34453
CLCA1 chloride channel accessory 1 2.34453
MAN2B1 mannosidase, alpha, class 2B, member 1 2.34453
CCDC27 coiled-coil domain containing 27 2.3422
CCDC152 coiled-coil domain containing 152 2.3422
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.33976
TFF3 trefoil factor 3 (intestinal) 2.32911
PROM1 prominin 1 2.3157
L1CAM L1 cell adhesion molecule 2.31501
APOLD1 apolipoprotein L domain containing 1 2.28345
SLC44A5 solute carrier family 44, member 5 2.27488
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 2.25222
PPM1M protein phosphatase, Mg2+/Mn2+ dependent, 1M 2.25065
ARSD arylsulfatase D 2.23527
ARHGAP9 Rho GTPase activating protein 9 2.23527
PSD4 pleckstrin and Sec7 domain containing 4 2.23527
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.23527
RNF170 ring finger protein 170 2.22625
CAMK2D calcium/calmodulin-dependent protein kinase II delta 2.2221
TMCO6 transmembrane and coiled-coil domains 6 2.2221
PRPF18 pre-mRNA processing factor 18 2.21617
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.17473
UQCRC2 ubiquinol-cytochrome c reductase core protein II 2.15315
PPID peptidylprolyl isomerase D 2.1508
FNTA farnesyltransferase, CAAX box, alpha 2.10874
SCML2 sex comb on midleg-like 2 (Drosophila) 2.07908
ZNF101 zinc finger protein 101 2.07908
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 2.07908
UBN1 ubinuclein 1 2.0724
STIL SCL/TAL1 interrupting locus 2.0724
CEP15 centrosomal protein 15 2.07153
ZNF844 zinc finger protein 844 2.06193
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.05629
SNX4 sorting nexin 4 2.05406
NUCB2 nucleobindin 2 2.04082
IPO9 importin 9 2.0404
ANKRD12 ankyrin repeat domain 12 2.0381
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.0381
MRPS24 mitochondrial ribosomal protein S24 2.02748
CINP cyclin-dependent kinase 2 interacting protein 2.02533
MACROD2 MACRO domain containing 2 2.02298
SRRM2 serine/arginine repetitive matrix 2 2.01364
COMMD9 COMM domain containing 9 2.01364
NF2 neurofibromin 2 (merlin) 2.01034
RAB2B RAB2B, member RAS oncogene family 2.01034
HESX1 HESX homeobox 1 2.00855

decreased expression

Symbol Name Standardized Value
TMEM45B transmembrane protein 45B -2.5559
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 -2.5559
UBAP2 ubiquitin associated protein 2 -2.5559
IFT70A intraflagellar transport 70A -2.5559
DPYD dihydropyrimidine dehydrogenase -2.5559
EMX1 empty spiracles homeobox 1 -2.5559
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 -2.5559
GPR20 G protein-coupled receptor 20 -2.5559
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.5559
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.5559
ZNF750 zinc finger protein 750 -2.5559
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.5559
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.5559
LRMDA leucine rich melanocyte differentiation associated -2.5092
CNGA1 cyclic nucleotide gated channel alpha 1 -2.46248
ECT2L epithelial cell transforming 2 like -2.38251
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.38251
TMEM144 transmembrane protein 144 -2.34453
HCST hematopoietic cell signal transducer -2.34453
WEE2 WEE1 homolog 2 (S. pombe) -2.34453
ADAD2 adenosine deaminase domain containing 2 -2.34453
RNF17 ring finger protein 17 -2.34453
KIRREL2 kin of IRRE like 2 (Drosophila) -2.34453
NAPSA napsin A aspartic peptidase -2.34453
LMO1 LIM domain only 1 (rhombotin 1) -2.34453
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -2.34453
CCDC85A coiled-coil domain containing 85A -2.34453
MID2 midline 2 -2.34453
FLII flightless I homolog (Drosophila) -2.34453
LEFTY1 left-right determination factor 1 -2.34453
FAM3D family with sequence similarity 3, member D -2.34453
RALGDS ral guanine nucleotide dissociation stimulator -2.34453
KASH5 KASH domain containing 5 -2.34453
PCNX3 pecanex 3 -2.34453
H2AX H2A.X variant histone -2.34453
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -2.34453
ELOVL2 ELOVL fatty acid elongase 2 -2.34453
FMO3 flavin containing monooxygenase 3 -2.34453
SHROOM2 shroom family member 2 -2.34453
TSPAN9 tetraspanin 9 -2.34453
C7ORF57 chromosome 7 open reading frame 57 -2.34453
PIWIL3 piwi-like RNA-mediated gene silencing 3 -2.34453
SUMO4 small ubiquitin-like modifier 4 -2.34453
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.34453
THPO thrombopoietin -2.34453
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.34453
ADGRG3 adhesion G protein-coupled receptor G3 -2.34453
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -2.34453
CFAP299 cilia and flagella associated protein 299 -2.34453
TDG thymine-DNA glycosylase -2.34453
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -2.34453
MAVS mitochondrial antiviral signaling protein -2.34453
PIH1D2 PIH1 domain containing 2 -2.34453
TMIGD3 transmembrane and immunoglobulin domain containing 3 -2.34453
CD177 CD177 molecule -2.34453
EBF2 early B-cell factor 2 -2.34453
TFG TRK-fused gene -2.34453
CSNK1G2 casein kinase 1, gamma 2 -2.34453
CNTF ciliary neurotrophic factor -2.34453
PLBD2 phospholipase B domain containing 2 -2.34453
C1ORF159 chromosome 1 open reading frame 159 -2.34453
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 -2.34453
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -2.34453
PPIG peptidylprolyl isomerase G (cyclophilin G) -2.34453
LHX2 LIM homeobox 2 -2.34453
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -2.34453
CBR4 carbonyl reductase 4 -2.34453
ANXA1 annexin A1 -2.34453
CPLX4 complexin 4 -2.34453
BTBD19 BTB (POZ) domain containing 19 -2.34453
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.34453
TP53INP2 tumor protein p53 inducible nuclear protein 2 -2.34453
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.34453
NPB neuropeptide B -2.34453
LAMB2 laminin, beta 2 (laminin S) -2.34453
ASCL5 achaete-scute family bHLH transcription factor 5 -2.34453
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -2.33976
CMTM3 CKLF-like MARVEL transmembrane domain containing 3 -2.33976
TMEM143 transmembrane protein 143 -2.27968
LIFR leukemia inhibitory factor receptor alpha -2.25222
TRAF5 TNF receptor-associated factor 5 -2.25222
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.24453
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -2.24235
KDM4D lysine (K)-specific demethylase 4D -2.2309
IL12RB2 interleukin 12 receptor, beta 2 -2.22427
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -2.22177
CELF2 CUGBP, Elav-like family member 2 -2.2192
PCNT pericentrin -2.21617
ZNF446 zinc finger protein 446 -2.19783
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.18018
FOXO6 forkhead box O6 -2.17473
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.15146
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -2.12819
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 -2.12393
LARP4 La ribonucleoprotein domain family, member 4 -2.09003
KLHL36 kelch-like family member 36 -2.09003
HEXD hexosaminidase D -2.08907
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -2.08223
CCNT1 cyclin T1 -2.07908
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -2.07691
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.0724
AGMO alkylglycerol monooxygenase -2.0724
JTB jumping translocation breakpoint -2.06093
TRIM13 tripartite motif containing 13 -2.04983
SOCS2 suppressor of cytokine signaling 2 -2.0381
ZNF221 zinc finger protein 221 -2.03077
SLMAP sarcolemma associated protein -2.029
ST7 suppression of tumorigenicity 7 -2.02869
STK26 serine/threonine protein kinase 26 -2.02533
MED12 mediator complex subunit 12 -2.02533
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -2.00852
PHF10 PHD finger protein 10 -2.00074