DMC1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description DNA meiotic recombinase 1|This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 11144)
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Genes

298 genes differentially expressed following the DMC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TUBA3D tubulin, alpha 3d 2.51666
ZNF502 zinc finger protein 502 2.51666
CDH5 cadherin 5, type 2 (vascular endothelium) 2.51666
WDR87 WD repeat domain 87 2.51666
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.51666
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.51666
MUC1 mucin 1, cell surface associated 2.51666
PCDHB7 protocadherin beta 7 2.51666
FOXA2 forkhead box A2 2.51666
TNNI1 troponin I type 1 (skeletal, slow) 2.51666
FGD2 FYVE, RhoGEF and PH domain containing 2 2.51666
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.51666
PCDHA8 protocadherin alpha 8 2.51666
SECTM1 secreted and transmembrane 1 2.51666
SIX2 SIX homeobox 2 2.51666
CST11 cystatin 11 2.51666
LURAP1L leucine rich adaptor protein 1-like 2.51666
CD93 CD93 molecule 2.51666
ALK anaplastic lymphoma receptor tyrosine kinase 2.51666
NAPSA napsin A aspartic peptidase 2.51666
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.51666
OR5K3 olfactory receptor, family 5, subfamily K, member 3 2.51666
CCNB3 cyclin B3 2.51666
ADTRP androgen-dependent TFPI-regulating protein 2.51666
REN renin 2.51666
GFI1 growth factor independent 1 transcription repressor 2.51666
RPL3L ribosomal protein L3-like 2.51666
HCST hematopoietic cell signal transducer 2.51666
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.51666
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.51666
SETSIP SET-like protein 2.51666
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.51666
SPACA5 sperm acrosome associated 5 2.51666
ASPA aspartoacylase 2.51666
RPE65 retinal pigment epithelium-specific protein 65kDa 2.51666
TMEM191B transmembrane protein 191B 2.51666
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.51666
FFAR4 free fatty acid receptor 4 2.51666
DSG2 desmoglein 2 2.51666
ARHGAP36 Rho GTPase activating protein 36 2.51666
FETUB fetuin B 2.51666
CEP295NL CEP295 N-terminal like 2.51666
SIGLEC9 sialic acid binding Ig-like lectin 9 2.51666
LRG1 leucine-rich alpha-2-glycoprotein 1 2.51666
OIT3 oncoprotein induced transcript 3 2.51666
WASL-DT WASL divergent transcript 2.51666
H2BC1 H2B clustered histone 1 2.51666
CES4A carboxylesterase 4A 2.51666
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 2.51666
YIPF7 Yip1 domain family, member 7 2.51666
GPX5 glutathione peroxidase 5 2.51666
SPEM1 spermatid maturation 1 2.51666
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.51666
FRG2C FSHD region gene 2 family, member C 2.51666
STX11 syntaxin 11 2.51666
MISP3 MISP family member 3 2.51666
DERPC DERPC proline and glycine rich nuclear protein 2.51666
LINC02268 long intergenic non-protein coding RNA 2268 2.51666
C19ORF85 chromosome 19 open reading frame 85 2.51666
NUDT4B nudix hydrolase 4B 2.51666
DEFB131A defensin beta 131A 2.51666
CFAP276 cilia and flagella associated protein 276 2.51666
CCDC190 coiled-coil domain containing 190 2.51666
ANKRD40CL ANKRD40 C-terminal like 2.51666
TBXT T-box transcription factor T 2.51666
TMEM275 transmembrane protein 275 2.51666
KRT80 keratin 80, type II 2.51666
LMNTD1 lamin tail domain containing 1 2.51666
SAG S-antigen; retina and pineal gland (arrestin) 2.51666
RUNX3 runt-related transcription factor 3 2.51666
MYH13 myosin, heavy chain 13, skeletal muscle 2.51666
IAPP islet amyloid polypeptide 2.51666
C1ORF162 chromosome 1 open reading frame 162 2.51666
CXCL16 chemokine (C-X-C motif) ligand 16 2.51666
SLPI secretory leukocyte peptidase inhibitor 2.51666
CD79A CD79a molecule, immunoglobulin-associated alpha 2.51666
CD79B CD79b molecule, immunoglobulin-associated beta 2.51666
SCN10A sodium channel, voltage gated, type X alpha subunit 2.51666
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.51666
TBX3 T-box 3 2.51666
RANGRF RAN guanine nucleotide release factor 2.51666
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.51666
PRDM7 PR domain containing 7 2.51666
DYNAP dynactin associated protein 2.51666
IL16 interleukin 16 2.51666
PTH parathyroid hormone 2.51666
SAA4 serum amyloid A4, constitutive 2.51666
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.51666
FAM186A family with sequence similarity 186, member A 2.51666
CCR6 chemokine (C-C motif) receptor 6 2.51666
EPGN epithelial mitogen 2.51666
PRSS38 protease, serine, 38 2.51666
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.51666
EHF ets homologous factor 2.51666
TRIM7 tripartite motif containing 7 2.51666
SOWAHC sosondowah ankyrin repeat domain family member C 2.51666
ORM2 orosomucoid 2 2.51666
PCDHGB1 protocadherin gamma subfamily B, 1 2.51666
GSC2 goosecoid homeobox 2 2.51666
ZNHIT6 zinc finger, HIT-type containing 6 2.51666
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 2.51666
CRABP1 cellular retinoic acid binding protein 1 2.51666
ANKRD62 ankyrin repeat domain 62 2.51666
CALML5 calmodulin-like 5 2.51666
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.51666
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.51666
C5AR2 complement component 5a receptor 2 2.51666
AMER2 APC membrane recruitment protein 2 2.51666
KLHL1 kelch-like family member 1 2.51666
CRYBB2 crystallin, beta B2 2.51666
KLHL41 kelch-like family member 41 2.51666
FBXO40 F-box protein 40 2.51666
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.51666
ZCCHC12 zinc finger, CCHC domain containing 12 2.51666
ISL1 ISL LIM homeobox 1 2.51666
VWA7 von Willebrand factor A domain containing 7 2.51666
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.51666
CLEC18C C-type lectin domain family 18, member C 2.51666
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene) 2.51666
MUC16 mucin 16, cell surface associated 2.51666
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.51666
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 2.51666
C16ORF78 chromosome 16 open reading frame 78 2.51666
HK3 hexokinase 3 (white cell) 2.51666
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.51666
TDRD15 tudor domain containing 15 2.51666
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.51666
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.51666
HPX hemopexin 2.51666
APOL4 apolipoprotein L, 4 2.51666
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.51666
RBP4 retinol binding protein 4, plasma 2.51666
FXYD2 FXYD domain containing ion transport regulator 2 2.51666
ANKRD30A ankyrin repeat domain 30A 2.51666
IL22RA1 interleukin 22 receptor, alpha 1 2.51666
HELZ2 helicase with zinc finger 2, transcriptional coactivator 2.51666
ASCL3 achaete-scute family bHLH transcription factor 3 2.51666
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.51666
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.51666
TMEM184A transmembrane protein 184A 2.51666
PODN podocan 2.51666
TPRX1 tetra-peptide repeat homeobox 1 2.51666
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 2.51666
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.51666
TMEM132C transmembrane protein 132C 2.51666
ARSH arylsulfatase family, member H 2.51666
EMCN endomucin 2.51666
FGF9 fibroblast growth factor 9 2.51666
PCDHGA11 protocadherin gamma subfamily A, 11 2.51666
IL23R interleukin 23 receptor 2.51666
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.51666
AGBL4 ATP/GTP binding protein-like 4 2.51666
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.51666
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.51666
PF4V1 platelet factor 4 variant 1 2.51666
TGM4 transglutaminase 4 2.51666
MMEL1 membrane metallo-endopeptidase-like 1 2.51666
APOL1 apolipoprotein L, 1 2.51666
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.51666
GOLGA8O golgin A8 family, member O 2.51666
ANGPTL3 angiopoietin-like 3 2.51666
TP63 tumor protein p63 2.51666
GBA1 glucosylceramidase beta 1 2.4979
TMEM187 transmembrane protein 187 2.44941
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.4491
FIMP1 fertilization-influencing membrane protein 1 2.44683
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.44683
STMP1 short transmembrane mitochondrial protein 1 2.43653
ILDR1 immunoglobulin-like domain containing receptor 1 2.42628
ZNF593OS ZNF593 opposite strand 2.40773
C3ORF49 chromosome 3 open reading frame 49 2.40604
CMC2 C-x(9)-C motif containing 2 2.38997
CDC20 cell division cycle 20 2.33643
DUSP14 dual specificity phosphatase 14 2.31497
BANP BTG3 associated nuclear protein 2.26171
IQSEC3 IQ motif and Sec7 domain 3 2.23467
DENND2D DENN/MADD domain containing 2D 2.22405
ZNF425 zinc finger protein 425 2.20292
KCTD3 potassium channel tetramerization domain containing 3 2.17674
JMJD6 jumonji domain containing 6 2.16787
ZNF205 zinc finger protein 205 2.14946
RABGGTB Rab geranylgeranyltransferase, beta subunit 2.14709
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 2.14553
MYH14 myosin, heavy chain 14, non-muscle 2.12801
KATNBL1 katanin p80 subunit B-like 1 2.12495
ZCWPW2 zinc finger, CW type with PWWP domain 2 2.12495
CPNE3 copine III 2.08718
PCSK7 proprotein convertase subtilisin/kexin type 7 2.05438
PML promyelocytic leukemia 2.05238
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 2.05106
TASOR transcription activation suppressor 2.04575
PCDHGA1 protocadherin gamma subfamily A, 1 2.03563
CGRRF1 cell growth regulator with ring finger domain 1 2.02092
RAP2C RAP2C, member of RAS oncogene family 2.01949
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 2.00851
METTL9 methyltransferase like 9 2.00556

decreased expression

Symbol Name Standardized Value
LOC112694756 uncharaterized LOC112694756 -2.51666
MYSM1 Myb-like, SWIRM and MPN domains 1 -2.51666
GJB3 gap junction protein, beta 3, 31kDa -2.51666
RXRA retinoid X receptor, alpha -2.51666
DZIP1 DAZ interacting zinc finger protein 1 -2.51666
ANGPTL7 angiopoietin-like 7 -2.51666
ZFYVE19 zinc finger, FYVE domain containing 19 -2.51666
MKKS McKusick-Kaufman syndrome -2.51666
LRRC31 leucine rich repeat containing 31 -2.51666
REEP1 receptor accessory protein 1 -2.51666
SLC51A solute carrier family 51, alpha subunit -2.51666
BCAS1 breast carcinoma amplified sequence 1 -2.51666
TMEM86A transmembrane protein 86A -2.51666
RNF222 ring finger protein 222 -2.51666
POTEJ POTE ankyrin domain family, member J -2.51666
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.51666
ZNF233 zinc finger protein 233 -2.51666
TUBB1 tubulin, beta 1 class VI -2.51666
ALDOB aldolase B, fructose-bisphosphate -2.51666
DNAAF1 dynein, axonemal, assembly factor 1 -2.51666
MLANA melan-A -2.51666
C4ORF50 chromosome 4 open reading frame 50 -2.51666
PCDHGC3 protocadherin gamma subfamily C, 3 -2.51666
C2CD3 C2 calcium-dependent domain containing 3 -2.51666
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b -2.51666
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -2.51666
GJA1 gap junction protein, alpha 1, 43kDa -2.51666
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.51666
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.51666
NXPH3 neurexophilin 3 -2.51666
PDYN prodynorphin -2.51666
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -2.51666
KANK4 KN motif and ankyrin repeat domains 4 -2.51666
ZMYND10 zinc finger, MYND-type containing 10 -2.51666
CD248 CD248 molecule, endosialin -2.51666
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 -2.51666
DND1 DND microRNA-mediated repression inhibitor 1 -2.51666
AGXT2 alanine--glyoxylate aminotransferase 2 -2.51666
GCOM1 GRINL1A complex locus 1 -2.51666
IGIP IgA-inducing protein -2.51666
TM4SF19 transmembrane 4 L six family member 19 -2.51666
NGB neuroglobin -2.51666
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.51666
HSPA1L heat shock 70kDa protein 1-like -2.51666
LRRN4 leucine rich repeat neuronal 4 -2.51666
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.51666
PFN4 profilin family, member 4 -2.51666
TFE3 transcription factor binding to IGHM enhancer 3 -2.4994
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C -2.45224
WDR5B WD repeat domain 5B -2.44325
ZC3H12B zinc finger CCCH-type containing 12B -2.40999
RAD51 RAD51 recombinase -2.40999
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -2.40773
MYPOP Myb-related transcription factor, partner of profilin -2.3979
PRKCB protein kinase C, beta -2.39455
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 -2.39455
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.39455
CFAP68 cilia and flagella associated protein 68 -2.39455
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.38997
TMEM248 transmembrane protein 248 -2.38918
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -2.37999
TMED5 transmembrane emp24 protein transport domain containing 5 -2.37999
BCOR BCL6 corepressor -2.36948
NADSYN1 NAD synthetase 1 -2.35939
IRF7 interferon regulatory factor 7 -2.35218
C1QL3 complement component 1, q subcomponent-like 3 -2.35218
FMO3 flavin containing monooxygenase 3 -2.3325
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.31283
GEMIN7 gem (nuclear organelle) associated protein 7 -2.31184
PELI1 pellino E3 ubiquitin protein ligase 1 -2.31059
PROCR protein C receptor, endothelial -2.3042
NRCAM neuronal cell adhesion molecule -2.29975
ERCC5 excision repair cross-complementation group 5 -2.29143
RAB2B RAB2B, member RAS oncogene family -2.29143
ADGRG5 adhesion G protein-coupled receptor G5 -2.28899
SPDYE3 speedy/RINGO cell cycle regulator family member E3 -2.21921
TCEAL7 transcription elongation factor A (SII)-like 7 -2.21875
TCF4 transcription factor 4 -2.20329
IGSF1 immunoglobulin superfamily, member 1 -2.20329
ZNF26 zinc finger protein 26 -2.19801
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.17352
AK1 adenylate kinase 1 -2.17313
LAD1 ladinin 1 -2.16863
TRIM58 tripartite motif containing 58 -2.14387
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -2.14034
TNXB tenascin XB -2.11525
ZDHHC3 zinc finger, DHHC-type containing 3 -2.1067
SOD1 superoxide dismutase 1, soluble -2.09801
H1-5 H1.5 linker histone, cluster member -2.06645
UNC50 unc-50 homolog (C. elegans) -2.0615
TAFA3 TAFA chemokine like family member 3 -2.0615
PLXDC1 plexin domain containing 1 -2.0615
TP73 tumor protein p73 -2.0615
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.0605
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 -2.05106
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -2.04194
ATP5MK ATP synthase membrane subunit k -2.03958
ZNF585A zinc finger protein 585A -2.03466
RAB3A RAB3A, member RAS oncogene family -2.0269
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.01619
CCT2 chaperonin containing TCP1, subunit 2 (beta) -2.00556
UEVLD UEV and lactate/malate dehyrogenase domains -2.00062