DMS-273 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description disease: carcinoma, small cell (Cell Line Ontology, CLO_0002797)
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Genes

287 genes with high or low expression in DMS-273 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
SCMH1 sex comb on midleg homolog 1 (Drosophila) 3.60177
SCNM1 sodium channel modifier 1 3.60177
NFYC nuclear transcription factor Y, gamma 3.60177
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 3.60177
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast) 3.60177
PRUNE prune exopolyphosphatase 3.60177
CTPS1 CTP synthase 1 3.60177
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 3.60177
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 3.60177
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 3.60177
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 3.60177
RFX5 regulatory factor X, 5 (influences HLA class II expression) 3.60073
MYCBP MYC binding protein 3.6005
SETDB1 SET domain, bifurcated 1 3.6005
ARNT aryl hydrocarbon receptor nuclear translocator 3.53056
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 3.5304
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 3.16726
RLF rearranged L-myc fusion 3.11067
CERS2 ceramide synthase 2 2.8886
RRAGC Ras-related GTP binding C 2.78032
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.60957
ZFP69B ZFP69 zinc finger protein B 2.6013
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 2.59727
ZMPSTE24 zinc metallopeptidase STE24 2.58785
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 2.58252
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.57503
ENSA endosulfine alpha 2.56932
GOLPH3L golgi phosphoprotein 3-like 2.54347
PPT1 palmitoyl-protein thioesterase 1 2.50361
MACF1 microtubule-actin crosslinking factor 1 2.50122
MCL1 myeloid cell leukemia 1 2.43348
POU3F1 POU class 3 homeobox 1 2.38949
MINA MYC induced nuclear antigen 2.3868
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 2.35318
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1 2.32177
RCC1 regulator of chromosome condensation 1 2.3137
OXCT2 3-oxoacid CoA transferase 2 2.29884
FAM63A family with sequence similarity 63, member A 2.28944
CDC42SE1 CDC42 small effector 1 2.24116
TRAP1 TNF receptor-associated protein 1 2.23979
OPRK1 opioid receptor, kappa 1 2.18769
SH3GL2 SH3-domain GRB2-like 2 2.18261
PPP5C protein phosphatase 5, catalytic subunit 2.17704
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 2.10032
NEUROD1 neuronal differentiation 1 2.09737
RGS16 regulator of G-protein signaling 16 2.09042
TRIT1 tRNA isopentenyltransferase 1 2.05431
POGZ pogo transposable element with ZNF domain 2.03392
GARS glycyl-tRNA synthetase 2.02681
RBM28 RNA binding motif protein 28 2.00774
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.00548
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.00084
BLMH bleomycin hydrolase 1.98848
RUVBL1 RuvB-like AAA ATPase 1 1.96972
KIAA0754 KIAA0754 1.94901
RABGGTB Rab geranylgeranyltransferase, beta subunit 1.94161
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 1.93356
ASNSD1 asparagine synthetase domain containing 1 1.93289
RIMS3 regulating synaptic membrane exocytosis 3 1.9041
RABEPK Rab9 effector protein with kelch motifs 1.90263
SPINK4 serine peptidase inhibitor, Kazal type 4 1.87993
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 1.87763
PRDM13 PR domain containing 13 1.87517
THBS4 thrombospondin 4 1.8724
ZFX zinc finger protein, X-linked 1.87074
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 1.85644
MPPE1 metallophosphoesterase 1 1.8474
SDHAF3 succinate dehydrogenase complex assembly factor 3 1.82362
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.81865
BMP8B bone morphogenetic protein 8b 1.80022
HDAC3 histone deacetylase 3 1.78788
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 1.78484
MRPS27 mitochondrial ribosomal protein S27 1.77794
PCOLCE2 procollagen C-endopeptidase enhancer 2 1.77171
DACH1 dachshund family transcription factor 1 1.76572
NHLH1 nescient helix loop helix 1 1.76464
EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.75822
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 1.74257
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 1.7121
REC8 REC8 meiotic recombination protein 1.68391
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.68124
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 1.6772
SNCB synuclein, beta 1.67059
SLN sarcolipin 1.6653
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 1.66427
APOC1 apolipoprotein C-I 1.66115
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.65277
COLGALT2 collagen beta(1-O)galactosyltransferase 2 1.6524
RAB26 RAB26, member RAS oncogene family 1.64929
PCCB propionyl CoA carboxylase, beta polypeptide 1.64378
SLC38A4 solute carrier family 38, member 4 1.64332
MLXIPL MLX interacting protein-like 1.63576
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 1.635
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 1.63277
TBRG4 transforming growth factor beta regulator 4 1.62919
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.62901
MFAP4 microfibrillar-associated protein 4 1.62709
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 1.62595
SCML2 sex comb on midleg-like 2 (Drosophila) 1.62367
ESM1 endothelial cell-specific molecule 1 1.61467
LPL lipoprotein lipase 1.61057
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.60875
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.60779
PUS7 pseudouridylate synthase 7 (putative) 1.604
LAS1L LAS1-like (S. cerevisiae) 1.5937
SLC35G2 solute carrier family 35, member G2 1.59217
WASF3 WAS protein family, member 3 1.58795
CHST10 carbohydrate sulfotransferase 10 1.57207
IPO7 importin 7 1.56499
ZNF282 zinc finger protein 282 1.56376
POLD2 polymerase (DNA directed), delta 2, accessory subunit 1.56371
CPVL carboxypeptidase, vitellogenic-like 1.5566
USP10 ubiquitin specific peptidase 10 1.55344
HRASLS HRAS-like suppressor 1.55113
TMX1 thioredoxin-related transmembrane protein 1 1.54818
FGF21 fibroblast growth factor 21 1.54502
KIAA1614 KIAA1614 1.53622
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 1.53533
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 1.52054
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 1.51832
CDH22 cadherin 22, type 2 1.51832
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.51447
KLHL23 kelch-like family member 23 1.51188
HBE1 hemoglobin, epsilon 1 1.50052
NRCAM neuronal cell adhesion molecule 1.50008
TRIM9 tripartite motif containing 9 1.49648
COPS6 COP9 signalosome subunit 6 1.48436
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.48404
OLIG2 oligodendrocyte lineage transcription factor 2 1.4831
ROR2 receptor tyrosine kinase-like orphan receptor 2 1.48241
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 1.47608
SCHIP1 schwannomin interacting protein 1 1.47423
PODXL2 podocalyxin-like 2 1.47309
CA5BP1 carbonic anhydrase VB pseudogene 1 1.47019
ZBTB18 zinc finger and BTB domain containing 18 1.46802
SEC14L5 SEC14-like 5 (S. cerevisiae) 1.45739
SIAH2 siah E3 ubiquitin protein ligase 2 1.4519
SRPK3 SRSF protein kinase 3 1.45088
QTRT1 queuine tRNA-ribosyltransferase 1 1.44954
TRPC1 transient receptor potential cation channel, subfamily C, member 1 1.44681
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.44413
TSHR thyroid stimulating hormone receptor 1.44275
ORC5 origin recognition complex, subunit 5 1.44092
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.43514
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 1.42557
ZIC3 Zic family member 3 1.42058
EXOSC5 exosome component 5 1.41717

low expression

Symbol Name Standardized Value
DDAH2 dimethylarginine dimethylaminohydrolase 2 -3.43693
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.87703
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -2.80044
TTN titin -2.52189
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.50849
IL6R interleukin 6 receptor -2.50074
DNAAF1 dynein, axonemal, assembly factor 1 -2.48667
HCRT hypocretin (orexin) neuropeptide precursor -2.47463
TMEM144 transmembrane protein 144 -2.39723
PRSS21 protease, serine, 21 (testisin) -2.38447
DCHS2 dachsous cadherin-related 2 -2.28669
SDPR serum deprivation response -2.28024
H2AFJ H2A histone family, member J -2.2761
UTRN utrophin -2.26621
KITLG KIT ligand -2.22482
EHBP1L1 EH domain binding protein 1-like 1 -2.22079
RGR retinal G protein coupled receptor -2.2177
SIGLEC8 sialic acid binding Ig-like lectin 8 -2.186
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.14593
TM7SF3 transmembrane 7 superfamily member 3 -2.12331
RAB1B RAB1B, member RAS oncogene family -2.10626
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.08531
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 -2.08221
PARD6B par-6 family cell polarity regulator beta -2.05624
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.03897
IGLL1 immunoglobulin lambda-like polypeptide 1 -2.03799
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -2.0299
BDNF brain-derived neurotrophic factor -2.02909
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.01728
HYAL4 hyaluronoglucosaminidase 4 -1.99781
ISG20 interferon stimulated exonuclease gene 20kDa -1.99688
HOXB8 homeobox B8 -1.99419
CA3 carbonic anhydrase III -1.99292
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -1.98422
TULP2 tubby like protein 2 -1.96769
RAB11A RAB11A, member RAS oncogene family -1.94714
TRAT1 T cell receptor associated transmembrane adaptor 1 -1.9384
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 -1.93746
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -1.91841
KIAA1033 KIAA1033 -1.91752
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -1.90874
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 -1.90058
FAM215A family with sequence similarity 215, member A (non-protein coding) -1.89992
SPP2 secreted phosphoprotein 2, 24kDa -1.89645
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -1.89254
TMEM134 transmembrane protein 134 -1.8905
F13B coagulation factor XIII, B polypeptide -1.87669
PRICKLE3 prickle homolog 3 (Drosophila) -1.8578
NRIP2 nuclear receptor interacting protein 2 -1.84207
ACRV1 acrosomal vesicle protein 1 -1.84002
COL26A1 collagen, type XXVI, alpha 1 -1.8361
GSTO1 glutathione S-transferase omega 1 -1.8348
CPN2 carboxypeptidase N, polypeptide 2 -1.83466
PARP3 poly (ADP-ribose) polymerase family, member 3 -1.83461
NES nestin -1.82453
RBM19 RNA binding motif protein 19 -1.81586
TMBIM1 transmembrane BAX inhibitor motif containing 1 -1.80051
FABP1 fatty acid binding protein 1, liver -1.7919
MCHR1 melanin-concentrating hormone receptor 1 -1.78534
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -1.78483
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -1.77404
ANGPT4 angiopoietin 4 -1.7606
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -1.75327
LAMB3 laminin, beta 3 -1.74869
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -1.74377
MYOZ1 myozenin 1 -1.73857
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 -1.72004
CLCN1 chloride channel, voltage-sensitive 1 -1.71907
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -1.71503
ACE angiotensin I converting enzyme -1.71189
IL17B interleukin 17B -1.71166
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -1.68431
SIGLEC5 sialic acid binding Ig-like lectin 5 -1.68391
CAPN1 calpain 1, (mu/I) large subunit -1.67456
POU1F1 POU class 1 homeobox 1 -1.6571
PLEC plectin -1.64977
GOLGA2 golgin A2 -1.64628
GH1 growth hormone 1 -1.64207
DCLRE1C DNA cross-link repair 1C -1.63777
MBL2 mannose-binding lectin (protein C) 2, soluble -1.63669
CYB5R3 cytochrome b5 reductase 3 -1.63443
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma -1.634
IL5 interleukin 5 -1.63249
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -1.63234
GZMM granzyme M (lymphocyte met-ase 1) -1.61849
GRB7 growth factor receptor-bound protein 7 -1.6171
DAZAP2 DAZ associated protein 2 -1.6153
ZMYND10 zinc finger, MYND-type containing 10 -1.6125
AKR1C4 aldo-keto reductase family 1, member C4 -1.60848
ANGPT2 angiopoietin 2 -1.60734
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -1.59497
NDOR1 NADPH dependent diflavin oxidoreductase 1 -1.59187
HOXB13 homeobox B13 -1.58995
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -1.58517
HIST1H4G histone cluster 1, H4g -1.57575
GCGR glucagon receptor -1.57258
SORCS3 sortilin-related VPS10 domain containing receptor 3 -1.5689
CD1E CD1e molecule -1.56846
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -1.56822
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -1.56748
FKBP2 FK506 binding protein 2, 13kDa -1.56504
SCN10A sodium channel, voltage gated, type X alpha subunit -1.56355
CRTAM cytotoxic and regulatory T cell molecule -1.56138
ZCCHC6 zinc finger, CCHC domain containing 6 -1.55417
VPS33B vacuolar protein sorting 33 homolog B (yeast) -1.55303
GHSR growth hormone secretagogue receptor -1.548
DPEP3 dipeptidase 3 -1.54701
LRRTM2 leucine rich repeat transmembrane neuronal 2 -1.53337
IL36A interleukin 36, alpha -1.52452
CAPN3 calpain 3, (p94) -1.52226
HOXB6 homeobox B6 -1.51808
RBMY2FP RNA binding motif protein, Y-linked, family 2, member F pseudogene -1.51231
IL36RN interleukin 36 receptor antagonist -1.51165
YIPF3 Yip1 domain family, member 3 -1.51116
RHBG Rh family, B glycoprotein (gene/pseudogene) -1.50837
SFTPC surfactant protein C -1.50791
LTC4S leukotriene C4 synthase -1.5019
RS1 retinoschisin 1 -1.49992
TRPM8 transient receptor potential cation channel, subfamily M, member 8 -1.4978
PAOX polyamine oxidase (exo-N4-amino) -1.49636
LMOD1 leiomodin 1 (smooth muscle) -1.48845
IL18R1 interleukin 18 receptor 1 -1.48609
CSF3 colony stimulating factor 3 (granulocyte) -1.48321
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 -1.48238
DERL2 derlin 2 -1.47705
ROPN1B rhophilin associated tail protein 1B -1.47109
MEOX2 mesenchyme homeobox 2 -1.46277
ALDOAP2 aldolase A, fructose-bisphosphate pseudogene 2 -1.45089
TGM3 transglutaminase 3 -1.44735
MRPL49 mitochondrial ribosomal protein L49 -1.44375
PCDHB8 protocadherin beta 8 -1.43909
ILK integrin-linked kinase -1.43807
COASY CoA synthase -1.43389
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -1.43032
LRRC14 leucine rich repeat containing 14 -1.42916
BST1 bone marrow stromal cell antigen 1 -1.42724
TMEM156 transmembrane protein 156 -1.42527
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -1.42387
PF4 platelet factor 4 -1.41994
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -1.41983