DNA integrity checkpoint signaling Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. (Gene Ontology, GO_0031570)
External Link http://amigo.geneontology.org/amigo/term/GO_0031570
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Genes

43 genes participating in the DNA integrity checkpoint signaling biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDT1 chromatin licensing and DNA replication factor 1
CEP63 centrosomal protein 63kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLOCK clock circadian regulator
CLSPN claspin
DNA2 DNA replication helicase/nuclease 2
DONSON downstream neighbor of SON
DOT1L DOT1-like histone H3K79 methyltransferase
DTX3L deltex 3 like, E3 ubiquitin ligase
E2F1 E2F transcription factor 1
ERCC4 excision repair cross-complementation group 4
ERCC6 excision repair cross-complementation group 6
FBXO6 F-box protein 6
H2AX H2A.X variant histone
HINFP histone H4 transcription factor
HUS1 HUS1 checkpoint homolog (S. pombe)
HUS1B HUS1 checkpoint homolog b (S. pombe)
INTS7 integrator complex subunit 7
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MRPL36 mitochondrial ribosomal protein L36
NBN nibrin
PARP9 poly (ADP-ribose) polymerase family, member 9
PRPF19 pre-mRNA processing factor 19
RAD17 RAD17 homolog (S. pombe)
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RPA4 replication protein A4, 30kDa
SETMAR SET domain and mariner transposase fusion gene
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TIPRL TOR signaling pathway regulator
TP53BP1 tumor protein p53 binding protein 1
UFL1 UFM1-specific ligase 1
USP28 ubiquitin specific peptidase 28