DNA metabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. (Gene Ontology, GO_0006259)
External Link http://amigo.geneontology.org/amigo/term/GO:0006259
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Genes

303 genes participating in the DNA metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
A1CF APOBEC1 complementation factor
ACD adrenocortical dysplasia homolog (mouse)
ACTL6A actin-like 6A
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADPRS ADP-ribosylserine hydrolase
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALKBH3 alkB, alkylation repair homolog 3 (E. coli)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLF aprataxin and PNKP like factor
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
ARTN artemin
ASF1A anti-silencing function 1A histone chaperone
ATM ATM serine/threonine kinase
ATRIP ATR interacting protein
AXIN2 axin 2
BARD1 BRCA1 associated RING domain 1
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTG2 BTG family, member 2
CDC34 cell division cycle 34
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPS-CORT CENPS-CORT readthrough
CHD1L chromodomain helicase DNA binding protein 1-like
CHEK1 checkpoint kinase 1
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNBP CCHC-type zinc finger, nucleic acid binding protein
CSNK1E casein kinase 1, epsilon
CTC1 CTS telomere maintenance complex component 1
DCLRE1B DNA cross-link repair 1B
DCLRE1C DNA cross-link repair 1C
DCTPP1 dCTP pyrophosphatase 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNA2 DNA replication helicase/nuclease 2
DNASE1 deoxyribonuclease I
DNASE1L1 deoxyribonuclease I-like 1
DNASE1L2 deoxyribonuclease I-like 2
DNASE1L3 deoxyribonuclease I-like 3
DNASE2 deoxyribonuclease II, lysosomal
DNTT DNA nucleotidylexotransferase
DONSON downstream neighbor of SON
DOT1L DOT1-like histone H3K79 methyltransferase
DUT deoxyuridine triphosphatase
EID3 EP300 interacting inhibitor of differentiation 3
ENDOG endonuclease G
ENDOV endonuclease V
EP400 E1A binding protein p400
ERCC1 excision repair cross-complementation group 1
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERCC6L excision repair cross-complementation group 6-like
EXD2 exonuclease 3'-5' domain containing 2
EXO1 exonuclease 1
FAM111A family with sequence similarity 111, member A
FAM111B family with sequence similarity 111, member B
FAN1 FANCD2/FANCI-associated nuclease 1
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCG Fanconi anemia, complementation group G
FANCL Fanconi anemia, complementation group L
FBH1 F-box DNA helicase 1
FBXO4 F-box protein 4
FBXO6 F-box protein 6
FEN1 flap structure-specific endonuclease 1
FMR1 fragile X mental retardation 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GEN1 GEN1 Holliday junction 5' flap endonuclease
GLRX2 glutaredoxin 2
GRWD1 glutamate-rich WD repeat containing 1
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HELB helicase (DNA) B
HID1 HID1 domain containing
HINFP histone H4 transcription factor
HLTF helicase-like transcription factor
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HORMAD1 HORMA domain containing 1
HUS1 HUS1 checkpoint homolog (S. pombe)
HUS1B HUS1 checkpoint homolog b (S. pombe)
IHO1 interactor of HORMAD1 1
INIP INTS3 and NABP interacting protein
INO80 INO80 complex subunit
INO80B INO80 complex subunit B
INO80C INO80 complex subunit C
INO80D INO80 complex subunit D
INO80E INO80 complex subunit E
INTS3 integrator complex subunit 3
ISG20 interferon stimulated exonuclease gene 20kDa
KIN Kin17 DNA and RNA binding protein
KMT5B lysine methyltransferase 5B
KMT5C lysine methyltransferase 5C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG4 ligase IV, DNA, ATP-dependent
LOC102724560 cystathionine beta-synthase
LONP1 lon peptidase 1, mitochondrial
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LRWD1 leucine-rich repeats and WD repeat domain containing 1
LTO1 LTO1 maturation factor of ABCE1
MACROH2A1 macroH2A.1 histone
MBD4 methyl-CpG binding domain protein 4
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCRS1 microspherule protein 1
MEI4 meiosis-specific 4 homolog (S. cerevisiae)
MEN1 multiple endocrine neoplasia I
MGMT O-6-methylguanine-DNA methyltransferase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRE11 MRE11 homolog, double strand break repair nuclease
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MUS81 MUS81 structure-specific endonuclease subunit
MUTYH mutY homolog
NABP1 nucleic acid binding protein 1
NABP2 nucleic acid binding protein 2
NAP1L1 nucleosome assembly protein 1-like 1
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFRKB nuclear factor related to kappaB binding protein
NHEJ1 nonhomologous end-joining factor 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOP53 NOP53 ribosome biogenesis factor
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSMCE3 NSE3 homolog, SMC5-SMC6 complex component
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae)
NT5E 5'-nucleotidase, ecto (CD73)
NT5M 5',3'-nucleotidase, mitochondrial
NTHL1 nth endonuclease III-like 1 (E. coli)
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
OGG1 8-oxoguanine DNA glycosylase
ORC3 origin recognition complex, subunit 3
ORC4 origin recognition complex, subunit 4
ORC5 origin recognition complex, subunit 5
ORC6 origin recognition complex, subunit 6
PARG poly (ADP-ribose) glycohydrolase
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PARP4 poly (ADP-ribose) polymerase family, member 4
PCLAF PCNA clamp associated factor
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PNKP polynucleotide kinase 3'-phosphatase
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLGARF POLG alternative reading frame
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSME4 proteasome (prosome, macropain) activator subunit 4
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTMS parathymosin
PURA purine-rich element binding protein A
PWWP3A PWWP domain containing 3A, DNA repair factor
RAD17 RAD17 homolog (S. pombe)
RAD18 RAD18 E3 ubiquitin protein ligase
RAD21 RAD21 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RAD52 RAD52 homolog (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RAD9B RAD9 homolog B (S. pombe)
RAG1 recombination activating gene 1
RAN RAN, member RAS oncogene family
RBBP8 retinoblastoma binding protein 8
RBMS1 RNA binding motif, single stranded interacting protein 1
REC114 REC114 meiotic recombination protein
RECQL RecQ helicase-like
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
REV1 REV1, polymerase (DNA directed)
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RMI2 RecQ mediated genome instability 2
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RPA4 replication protein A4, 30kDa
RPS3 ribosomal protein S3
RRAD Ras-related associated with diabetes
RRM1 ribonucleotide reductase M1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RTEL1 regulator of telomere elongation helicase 1
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SAMHD1 SAM domain and HD domain 1
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
SET SET nuclear proto-oncogene
SETMAR SET domain and mariner transposase fusion gene
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX4 SLX4 structure-specific endonuclease subunit
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMC1A structural maintenance of chromosomes 1A
SP100 SP100 nuclear antigen
SPO11 SPO11 meiotic protein covalently bound to DSB
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STN1 STN1 subunit of CST complex
SUMO1 small ubiquitin-like modifier 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBRG1 transforming growth factor beta regulator 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TDG thymine-DNA glycosylase
TDP1 tyrosyl-DNA phosphodiesterase 1
TDRD3 tudor domain containing 3
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TERT telomerase reverse transcriptase
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
THAP9 THAP domain containing 9
TICRR TOPBP1-interacting checkpoint and replication regulator
TIMELESS timeless circadian clock
TOP1 topoisomerase (DNA) I
TOP1MT topoisomerase (DNA) I, mitochondrial
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TOP3A topoisomerase (DNA) III alpha
TOP3B topoisomerase (DNA) III beta
TOP6BL TOP6B like initiator of meiotic double strand breaks
TOPBP1 topoisomerase (DNA) II binding protein 1
TREX1 three prime repair exonuclease 1
TREX2 three prime repair exonuclease 2
TRIM28 tripartite motif containing 28
TTF2 transcription termination factor, RNA polymerase II
TYMS thymidylate synthetase
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2N ubiquitin-conjugating enzyme E2N
UBE2T ubiquitin-conjugating enzyme E2T
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
USP3 ubiquitin specific peptidase 3
USP45 ubiquitin specific peptidase 45
UVRAG UV radiation resistance associated
VCP valosin containing protein
WDHD1 WD repeat and HMG-box DNA binding protein 1
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YY1 YY1 transcription factor
ZBTB1 zinc finger and BTB domain containing 1
ZNF365 zinc finger protein 365
ZNF668 zinc finger protein 668
ZNF827 zinc finger protein 827
ZNF83 zinc finger protein 83
ZPR1 ZPR1 zinc finger
ZRANB3 zinc finger, RAN-binding domain containing 3