DNA polymerase III complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. (Gene Ontology, GO_0009360)
External Link http://amigo.geneontology.org/amigo/term/GO:0009360
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Genes

716 proteins co-occuring with the DNA polymerase III complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
RAD17 RAD17 homolog (S. pombe) 3.506
PCNA proliferating cell nuclear antigen 3.363
RFC2 replication factor C (activator 1) 2, 40kDa 3.357
HUS1 HUS1 checkpoint homolog (S. pombe) 3.261
RAD9A RAD9 homolog A (S. pombe) 3.217
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 3.175
ATAD5 ATPase family, AAA domain containing 5 3.095
RFC5 replication factor C (activator 1) 5, 36.5kDa 3.088
RFC3 replication factor C (activator 1) 3, 38kDa 2.978
RFC4 replication factor C (activator 1) 4, 37kDa 2.933
TOPBP1 topoisomerase (DNA) II binding protein 1 2.908
RAD51 RAD51 recombinase 2.904
ATRIP ATR interacting protein 2.86
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 2.782
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 2.747
FEN1 flap structure-specific endonuclease 1 2.709
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.677
CDC45 cell division cycle 45 2.651
DSCC1 DNA replication and sister chromatid cohesion 1 2.638
CLSPN claspin 2.591
EXO1 exonuclease 1 2.544
CHEK1 checkpoint kinase 1 2.541
CDC6 cell division cycle 6 2.505
SSBP1 single-stranded DNA binding protein 1, mitochondrial 2.474
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 2.468
POLL polymerase (DNA directed), lambda 2.411
RAD18 RAD18 E3 ubiquitin protein ligase 2.407
MSH3 mutS homolog 3 2.404
DNA2 DNA replication helicase/nuclease 2 2.391
MCM10 minichromosome maintenance complex component 10 2.383
CDT1 chromatin licensing and DNA replication factor 1 2.376
CHEK2 checkpoint kinase 2 2.367
RAD50 RAD50 homolog (S. cerevisiae) 2.313
MSH6 mutS homolog 6 2.294
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 2.279
ATM ATM serine/threonine kinase 2.27
TENT4A terminal nucleotidyltransferase 4A 2.248
RAD52 RAD52 homolog (S. cerevisiae) 2.232
MCM4 minichromosome maintenance complex component 4 2.214
POLM polymerase (DNA directed), mu 2.214
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 2.213
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.171
MCM7 minichromosome maintenance complex component 7 2.155
MSH2 mutS homolog 2 2.153
REV1 REV1, polymerase (DNA directed) 2.135
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.13
ORC5 origin recognition complex, subunit 5 2.122
TIPIN TIMELESS interacting protein 2.114
DBF4 DBF4 zinc finger 2.114
WRNIP1 Werner helicase interacting protein 1 2.088
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.082
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 2.077
MCM3 minichromosome maintenance complex component 3 2.056
MCM6 minichromosome maintenance complex component 6 2.054
MUS81 MUS81 structure-specific endonuclease subunit 2.04
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2.026
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 2.026
TP53BP1 tumor protein p53 binding protein 1 2.01
MCM5 minichromosome maintenance complex component 5 1.994
USP1 ubiquitin specific peptidase 1 1.971
MDC1 mediator of DNA-damage checkpoint 1 1.969
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.967
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 1.963
BRCA1 breast cancer 1, early onset 1.957
WRN Werner syndrome, RecQ helicase-like 1.95
MLH1 mutL homolog 1 1.945
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 1.945
NPTN neuroplastin 1.934
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.93
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 1.929
TIMELESS timeless circadian clock 1.916
RPA3 replication protein A3, 14kDa 1.905
GINS3 GINS complex subunit 3 (Psf3 homolog) 1.9
ORC3 origin recognition complex, subunit 3 1.898
WDR48 WD repeat domain 48 1.884
POLD2 polymerase (DNA directed), delta 2, accessory subunit 1.878
TICRR TOPBP1-interacting checkpoint and replication regulator 1.872
ETAA1 Ewing tumor-associated antigen 1 1.865
POLH polymerase (DNA directed), eta 1.865
ORC4 origin recognition complex, subunit 4 1.855
PRIMPOL primase and polymerase (DNA-directed) 1.853
POLR1A polymerase (RNA) I polypeptide A, 194kDa 1.843
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.842
ORC6 origin recognition complex, subunit 6 1.842
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.84
RBBP8 retinoblastoma binding protein 8 1.839
FANCD2 Fanconi anemia, complementation group D2 1.834
RMI1 RecQ mediated genome instability 1 1.832
TOP1 topoisomerase (DNA) I 1.824
CDC7 cell division cycle 7 1.823
PRIM2 primase, DNA, polypeptide 2 (58kDa) 1.818
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 1.809
FANCI Fanconi anemia, complementation group I 1.806
HLTF helicase-like transcription factor 1.796
POLI polymerase (DNA directed) iota 1.791
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.785
PDS5A PDS5 cohesin associated factor A 1.778
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 1.775
MLH3 mutL homolog 3 1.77
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 1.765
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.762
XPA xeroderma pigmentosum, complementation group A 1.754
NEIL1 nei endonuclease VIII-like 1 (E. coli) 1.753
FANCM Fanconi anemia, complementation group M 1.742
DNAH8 dynein, axonemal, heavy chain 8 1.742
ERCC1 excision repair cross-complementation group 1 1.742
POLR1B polymerase (RNA) I polypeptide B, 128kDa 1.739
PIF1 PIF1 5'-to-3' DNA helicase 1.737
BRCA2 breast cancer 2, early onset 1.721
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.716
ERCC2 excision repair cross-complementation group 2 1.706
TLK1 tousled-like kinase 1 1.696
OGG1 8-oxoguanine DNA glycosylase 1.694
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 1.691
H2AC20 H2A clustered histone 20 1.686
H2AC19 H2A clustered histone 19 1.685
MRC1 mannose receptor, C type 1 1.673
STN1 STN1 subunit of CST complex 1.672
FBH1 F-box DNA helicase 1 1.67
EME1 essential meiotic structure-specific endonuclease 1 1.665
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 1.661
SRSF1 serine/arginine-rich splicing factor 1 1.652
SUGP1 SURP and G patch domain containing 1 1.647
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 1.645
UBE2N ubiquitin-conjugating enzyme E2N 1.644
SMC3 structural maintenance of chromosomes 3 1.638
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase 1.63
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 1.627
ZRANB3 zinc finger, RAN-binding domain containing 3 1.621
MUTYH mutY homolog 1.62
CRYBG1 crystallin beta-gamma domain containing 1 1.612
TOP3A topoisomerase (DNA) III alpha 1.605
GP5 glycoprotein V (platelet) 1.601
TP53 tumor protein p53 1.597
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.596
H2AX H2A.X variant histone 1.594
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.592
TDG thymine-DNA glycosylase 1.591
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.586
CRB2 crumbs family member 2 1.583
PNKP polynucleotide kinase 3'-phosphatase 1.583
LAMC3 laminin, gamma 3 1.576
DARS1 aspartyl-tRNA synthetase 1 1.572
TBX22 T-box 22 1.568
UBE2I ubiquitin-conjugating enzyme E2I 1.567
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 1.567
RAD9B RAD9 homolog B (S. pombe) 1.566
APTX aprataxin 1.552
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 1.55
RNASEH2A ribonuclease H2, subunit A 1.544
GEN1 GEN1 Holliday junction 5' flap endonuclease 1.541
RECQL RecQ helicase-like 1.535
YME1L1 YME1-like 1 ATPase 1.533
RTEL1 regulator of telomere elongation helicase 1 1.533
DUT deoxyuridine triphosphatase 1.525
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 1.522
POLE polymerase (DNA directed), epsilon, catalytic subunit 1.514
RAD54B RAD54 homolog B (S. cerevisiae) 1.514
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 1.512
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 1.512
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 1.508
SLX4 SLX4 structure-specific endonuclease subunit 1.507
MSH4 mutS homolog 4 1.505
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 1.503
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 1.502
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 1.498
UNG uracil-DNA glycosylase 1.49
TDP1 tyrosyl-DNA phosphodiesterase 1 1.487
RRAD Ras-related associated with diabetes 1.477
MCM9 minichromosome maintenance complex component 9 1.473
NTHL1 nth endonuclease III-like 1 (E. coli) 1.471
H3-7 H3.7 histone (putative) 1.464
CDC25A cell division cycle 25A 1.462
H3C13 H3 clustered histone 13 1.458
H3-5 H3.5 histone 1.458
NIPBL Nipped-B homolog (Drosophila) 1.457
H3-4 H3.4 histone, cluster member 1.457
H3-3B H3.3 histone B 1.454
TOP2A topoisomerase (DNA) II alpha 170kDa 1.451
CDK1 cyclin-dependent kinase 1 1.448
POLK polymerase (DNA directed) kappa 1.448
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 1.448
FBF1 Fas (TNFRSF6) binding factor 1 1.447
WAPL WAPL cohesin release factor 1.445
ERCC3 excision repair cross-complementation group 3 1.444
NBPF4 neuroblastoma breakpoint family, member 4 1.443
SPRTN SprT-like N-terminal domain 1.44
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.439
RUVBL1 RuvB-like AAA ATPase 1 1.437
CDK2 cyclin-dependent kinase 2 1.436
MMUT methylmalonyl-CoA mutase 1.428
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 1.423
FAN1 FANCD2/FANCI-associated nuclease 1 1.421
SMC5 structural maintenance of chromosomes 5 1.419
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 1.418
PIAS2 protein inhibitor of activated STAT, 2 1.417
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 1.415
MTIF2 mitochondrial translational initiation factor 2 1.407
XPC xeroderma pigmentosum, complementation group C 1.406
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.404
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 1.403
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.403
HSPE1 heat shock 10kDa protein 1 1.392
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 1.386
HUS1B HUS1 checkpoint homolog b (S. pombe) 1.379
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.379
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 1.378
H2BC21 H2B clustered histone 21 1.376
CHAF1A chromatin assembly factor 1, subunit A (p150) 1.374
GALK1 galactokinase 1 1.372
EPRS1 glutamyl-prolyl-tRNA synthetase 1 1.367
HELQ helicase, POLQ-like 1.364
PARP2 poly (ADP-ribose) polymerase 2 1.36
PARP1 poly (ADP-ribose) polymerase 1 1.359
RECQL5 RecQ protein-like 5 1.358
UBL3 ubiquitin-like 3 1.347
FAAP24 FA core complex associated protein 24 1.339
MMS22L MMS22-like, DNA repair protein 1.337
NHEJ1 nonhomologous end-joining factor 1 1.336
LIG4 ligase IV, DNA, ATP-dependent 1.325
PMEPA1 prostate transmembrane protein, androgen induced 1 1.325
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 1.323
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.321
MCM8 minichromosome maintenance complex component 8 1.321
CHD7 chromodomain helicase DNA binding protein 7 1.321
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.316
PALB2 partner and localizer of BRCA2 1.311
RFWD3 ring finger and WD repeat domain 3 1.309
RAD21 RAD21 homolog (S. pombe) 1.304
RAD23B RAD23 homolog B (S. cerevisiae) 1.295
ASF1A anti-silencing function 1A histone chaperone 1.293
CCNA2 cyclin A2 1.291
NEIL2 nei endonuclease VIII-like 2 (E. coli) 1.286
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 1.284
FANCA Fanconi anemia, complementation group A 1.281
FAM111A family with sequence similarity 111, member A 1.281
RMI2 RecQ mediated genome instability 2 1.278
CASS4 Cas scaffolding protein family member 4 1.268
TONSL tonsoku-like, DNA repair protein 1.266
FANCE Fanconi anemia, complementation group E 1.266
CDC5L cell division cycle 5-like 1.265
RAD51C RAD51 paralog C 1.263
ERCC6 excision repair cross-complementation group 6 1.263
DDB1 damage-specific DNA binding protein 1, 127kDa 1.256
DCLRE1A DNA cross-link repair 1A 1.255
MAU2 MAU2 sister chromatid cohesion factor 1.252
PCLAF PCNA clamp associated factor 1.252
TXN2 thioredoxin 2 1.251
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 1.245
DDAH2 dimethylarginine dimethylaminohydrolase 2 1.245
VCP valosin containing protein 1.242
POLN polymerase (DNA directed) nu 1.23
SSRP1 structure specific recognition protein 1 1.226
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 1.216
SPO11 SPO11 meiotic protein covalently bound to DSB 1.211
SIVA1 SIVA1, apoptosis-inducing factor 1.211
HROB homologous recombination factor with OB-fold 1.204
BLM Bloom syndrome, RecQ helicase-like 1.2
CHAF1B chromatin assembly factor 1, subunit B (p60) 1.2
RAD51AP1 RAD51 associated protein 1 1.195
TOR1AIP2 torsin A interacting protein 2 1.194
DDAH1 dimethylarginine dimethylaminohydrolase 1 1.194
MCMBP minichromosome maintenance complex binding protein 1.192
SUMO1 small ubiquitin-like modifier 1 1.189
NEIL3 nei endonuclease VIII-like 3 (E. coli) 1.186
RECQL4 RecQ protein-like 4 1.186
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.182
UHRF1 ubiquitin-like with PHD and ring finger domains 1 1.173
ERRFI1 ERBB receptor feedback inhibitor 1 1.171
ERCC4 excision repair cross-complementation group 4 1.171
TOR2A torsin family 2, member A 1.165
UIMC1 ubiquitin interaction motif containing 1 1.152
PLK1 polo-like kinase 1 1.147
MRE11 MRE11 homolog, double strand break repair nuclease 1.145
RAD54L RAD54-like (S. cerevisiae) 1.144
CD36 CD36 molecule (thrombospondin receptor) 1.14
UBE2K ubiquitin-conjugating enzyme E2K 1.139
SCAI suppressor of cancer cell invasion 1.138
RUVBL2 RuvB-like AAA ATPase 2 1.135
SETX senataxin 1.135
WEE1 WEE1 G2 checkpoint kinase 1.135
CCNA1 cyclin A1 1.133
CRBN cereblon 1.124
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 1.123
ASF1B anti-silencing function 1B histone chaperone 1.122
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.118
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 1.116
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.115
ARTN artemin 1.114
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 1.111
PPP4R3B protein phosphatase 4 regulatory subunit 3B 1.111
FANCL Fanconi anemia, complementation group L 1.107
NAP1L1 nucleosome assembly protein 1-like 1 1.106
ADCY10 adenylate cyclase 10 (soluble) 1.098
BARD1 BRCA1 associated RING domain 1 1.094
CDPF1 cysteine-rich, DPF motif domain containing 1 1.086
TOP2B topoisomerase (DNA) II beta 180kDa 1.085
DDB2 damage-specific DNA binding protein 2, 48kDa 1.081
FAAP100 FA core complex associated protein 100 1.079
LINS1 lines homolog 1 1.07
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.066
TOP3B topoisomerase (DNA) III beta 1.061
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 1.061
RNF4 ring finger protein 4 1.057
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 1.051
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 1.048
PPP4C protein phosphatase 4, catalytic subunit 1.044
PURB purine-rich element binding protein B 1.042
SMC6 structural maintenance of chromosomes 6 1.041
CDC25C cell division cycle 25C 1.036
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 1.036
OR10A7 olfactory receptor, family 10, subfamily A, member 7 1.033
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.029
WWOX WW domain containing oxidoreductase 1.026
TTK TTK protein kinase 1.025
TYMS thymidylate synthetase 1.024
MSH5 mutS homolog 5 1.022
TJAP1 tight junction associated protein 1 (peripheral) 1.02
TECRL trans-2,3-enoyl-CoA reductase-like 1.018
SIRT2 sirtuin 2 1.016
ENDOV endonuclease V 1.016
NEK1 NIMA-related kinase 1 1.015
FSBP fibrinogen silencer binding protein 1.014
H4C7 H4 clustered histone 7 1.014
PHGDH phosphoglycerate dehydrogenase 1.009
NLRP4 NLR family, pyrin domain containing 4 1.007
RNASEH2B ribonuclease H2, subunit B 1.005
ATMIN ATM interactor 1.002
AARS1 alanyl-tRNA synthetase 1 1.001
HDAC1 histone deacetylase 1 1.0
TBL1X transducin (beta)-like 1X-linked 0.998
H4C15 H4 clustered histone 15 0.996
SP100 SP100 nuclear antigen 0.995
DEDD death effector domain containing 0.992
MPG N-methylpurine-DNA glycosylase 0.991
FANCC Fanconi anemia, complementation group C 0.989
NSMCE3 NSE3 homolog, SMC5-SMC6 complex component 0.987
PAXX PAXX non-homologous end joining factor 0.987
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.987
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.987
PARG poly (ADP-ribose) glycohydrolase 0.981
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.981
RCC1 regulator of chromosome condensation 1 0.98
LGALS4 lectin, galactoside-binding, soluble, 4 0.975
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 0.973
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 0.969
FHIT fragile histidine triad 0.968
NOL7 nucleolar protein 7, 27kDa 0.963
TWNK twinkle mtDNA helicase 0.961
DIAPH2 diaphanous-related formin 2 0.96
TCEA1 transcription elongation factor A (SII), 1 0.959
CNOT11 CCR4-NOT transcription complex, subunit 11 0.958
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.954
SHISA3 shisa family member 3 0.953
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.952
ZNF829 zinc finger protein 829 0.952
FANCG Fanconi anemia, complementation group G 0.949
H2BC1 H2B clustered histone 1 0.949
KAT5 K(lysine) acetyltransferase 5 0.946
HSPB6 heat shock protein, alpha-crystallin-related, B6 0.946
CDCA5 cell division cycle associated 5 0.946
E2F1 E2F transcription factor 1 0.946
RPL11 ribosomal protein L11 0.944
EME2 essential meiotic structure-specific endonuclease subunit 2 0.944
TMEM107 transmembrane protein 107 0.939
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.937
FAAP20 FA core complex associated protein 20 0.936
UBE2T ubiquitin-conjugating enzyme E2T 0.935
DPH5 diphthamide biosynthesis 5 0.933
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.931
H2BK1 H2B.K variant histone 1 0.93
CUL4A cullin 4A 0.93
H2BC12L H2B clustered histone 12 like 0.928
H2BW1 H2B.W histone 1 0.928
H2BW2 H2B.W histone 2 0.928
H2BC13 H2B clustered histone 13 0.926
USP20 ubiquitin specific peptidase 20 0.926
H2BC18 H2B clustered histone 18 0.925
H2BC9 H2B clustered histone 9 0.924
H2BC14 H2B clustered histone 14 0.924
H2BC17 H2B clustered histone 17 0.923
H2BC26 H2B clustered histone 26 0.923
CCNB1 cyclin B1 0.922
SEPTIN7 septin 7 0.921
H2BC15 H2B clustered histone 15 0.92
H2BC3 H2B clustered histone 3 0.919
BRD4 bromodomain containing 4 0.918
H2BC11 H2B clustered histone 11 0.918
NABP2 nucleic acid binding protein 2 0.918
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) 0.916
H2BC12 H2B clustered histone 12 0.915
FOXN2 forkhead box N2 0.912
RRM1 ribonucleotide reductase M1 0.911
RNF169 ring finger protein 169 0.909
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.908
H2BC4 H2B clustered histone 4 0.908
CDC25B cell division cycle 25B 0.906
CCNL2 cyclin L2 0.906
CDC20 cell division cycle 20 0.906
H2BC5 H2B clustered histone 5 0.904
MDN1 MDN1, midasin homolog (yeast) 0.902
RAD51B RAD51 paralog B 0.901
APLF aprataxin and PNKP like factor 0.901
ELP4 elongator acetyltransferase complex subunit 4 0.9
DPH2 DPH2 homolog (S. cerevisiae) 0.898
RNASEH1 ribonuclease H1 0.89
TBP TATA box binding protein 0.889
SHISA2 shisa family member 2 0.888
TCEA2 transcription elongation factor A (SII), 2 0.883
KMT5A lysine methyltransferase 5A 0.881
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.879
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.876
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.876
TCEA3 transcription elongation factor A (SII), 3 0.875
MRPL36 mitochondrial ribosomal protein L36 0.875
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.871
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 0.871
MPLKIP M-phase specific PLK1 interacting protein 0.871
TREX1 three prime repair exonuclease 1 0.869
MGMT O-6-methylguanine-DNA methyltransferase 0.865
CDKN2A cyclin-dependent kinase inhibitor 2A 0.859
TDP2 tyrosyl-DNA phosphodiesterase 2 0.859
MAPK1 mitogen-activated protein kinase 1 0.855
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.854
CDA cytidine deaminase 0.852
MMP11 matrix metallopeptidase 11 0.85
CINP cyclin-dependent kinase 2 interacting protein 0.847
KAT2A K(lysine) acetyltransferase 2A 0.846
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.844
DNLZ DNL-type zinc finger 0.844
RRM2 ribonucleotide reductase M2 0.844
PPCS phosphopantothenoylcysteine synthetase 0.842
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.84
HORMAD2 HORMA domain containing 2 0.839
SENP6 SUMO1/sentrin specific peptidase 6 0.839
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.839
ADARB1 adenosine deaminase, RNA-specific, B1 0.838
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 0.835
TELO2 telomere maintenance 2 0.833
HORMAD1 HORMA domain containing 1 0.833
BRAT1 BRCA1-associated ATM activator 1 0.832
CTRB1 chymotrypsinogen B1 0.827
COASY CoA synthase 0.824
FANCB Fanconi anemia, complementation group B 0.823
HDAC8 histone deacetylase 8 0.821
PEX6 peroxisomal biogenesis factor 6 0.82
QTRT1 queuine tRNA-ribosyltransferase 1 0.818
PABPC1 poly(A) binding protein, cytoplasmic 1 0.818
GPN1 GPN-loop GTPase 1 0.817
KAT2B K(lysine) acetyltransferase 2B 0.817
GATAD2B GATA zinc finger domain containing 2B 0.814
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.813
TRRAP transformation/transcription domain-associated protein 0.813
AURKB aurora kinase B 0.812
TLK2 tousled-like kinase 2 0.811
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.81
GTF2B general transcription factor IIB 0.805
H1-0 H1.0 linker histone 0.803
CHD4 chromodomain helicase DNA binding protein 4 0.8
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.798
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.798
HDAC2 histone deacetylase 2 0.797
CTRB2 chymotrypsinogen B2 0.796
EIF5B eukaryotic translation initiation factor 5B 0.789
TOP1MT topoisomerase (DNA) I, mitochondrial 0.789
GP2 glycoprotein 2 (zymogen granule membrane) 0.788
TYRP1 tyrosinase-related protein 1 0.787
EP300 E1A binding protein p300 0.782
GP9 glycoprotein IX (platelet) 0.781
TCHP trichoplein, keratin filament binding 0.78
HID1 HID1 domain containing 0.779
UBA2 ubiquitin-like modifier activating enzyme 2 0.778
C6ORF89 chromosome 6 open reading frame 89 0.777
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 0.777
PXDNL peroxidasin-like 0.775
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.774
PXDN peroxidasin 0.773
RNF2 ring finger protein 2 0.773
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.771
SIRT1 sirtuin 1 0.764
SMC1A structural maintenance of chromosomes 1A 0.762
NOP58 NOP58 ribonucleoprotein 0.759
FBXW10 F-box and WD repeat domain containing 10 0.759
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.757
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 0.753
RNF113A ring finger protein 113A 0.753
CLMP CXADR-like membrane protein 0.753
H3C7 H3 clustered histone 7 0.751
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.75
PHAX phosphorylated adaptor for RNA export 0.749
HELLS helicase, lymphoid-specific 0.747
CETN2 centrin, EF-hand protein, 2 0.746
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.746
PTCH2 patched 2 0.745
TREX2 three prime repair exonuclease 2 0.744
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 0.739
SEM1 SEM1 26S proteasome subunit 0.738
DOT1L DOT1-like histone H3K79 methyltransferase 0.736
HDAC3 histone deacetylase 3 0.735
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 0.734
DCTD dCMP deaminase 0.733
MYSM1 Myb-like, SWIRM and MPN domains 1 0.733
SARS1 seryl-tRNA synthetase 1 0.731
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.729
PDS5B PDS5 cohesin associated factor B 0.728
CDC27 cell division cycle 27 0.728
SMC1B structural maintenance of chromosomes 1B 0.726
GTPBP1 GTP binding protein 1 0.726
VARS1 valyl-tRNA synthetase 1 0.726
POT1 protection of telomeres 1 0.723
FANCF Fanconi anemia, complementation group F 0.723
SARS2 seryl-tRNA synthetase 2, mitochondrial 0.72
TOR1A torsin family 1, member A (torsin A) 0.719
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.716
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.716
PARP3 poly (ADP-ribose) polymerase family, member 3 0.715
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.714
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.714
NAP1L4 nucleosome assembly protein 1-like 4 0.712
NOP56 NOP56 ribonucleoprotein 0.712
H2AZ1 H2A.Z variant histone 1 0.712
SHISA9 shisa family member 9 0.709
NFS1 NFS1 cysteine desulfurase 0.707
CLSTN1 calsyntenin 1 0.706
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.704
MCPH1 microcephalin 1 0.703
CFAP20 cilia and flagella associated protein 20 0.703
POTEF POTE ankyrin domain family, member F 0.701
IDNK idnK, gluconokinase homolog (E. coli) 0.697
INTS3 integrator complex subunit 3 0.697
VARS2 valyl-tRNA synthetase 2, mitochondrial 0.695
NCOA4 nuclear receptor coactivator 4 0.694
SRFBP1 serum response factor binding protein 1 0.694
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.694
HAPLN1 hyaluronan and proteoglycan link protein 1 0.693
ZSCAN5A zinc finger and SCAN domain containing 5A 0.688
ACOD1 aconitate decarboxylase 1 0.687
EIF4A3 eukaryotic translation initiation factor 4A3 0.686
MBD4 methyl-CpG binding domain protein 4 0.685
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 0.684
NUCB1 nucleobindin 1 0.682
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.681
YBX1 Y box binding protein 1 0.68
CD151 CD151 molecule (Raph blood group) 0.678
GLYATL1 glycine-N-acyltransferase-like 1 0.677
DIAPH3 diaphanous-related formin 3 0.676
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.675
FAM83A family with sequence similarity 83, member A 0.675
SUMO2 small ubiquitin-like modifier 2 0.674
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.673
MTUS1 microtubule associated tumor suppressor 1 0.67
SP9 Sp9 transcription factor 0.668
ZNF569 zinc finger protein 569 0.668
CTPS2 CTP synthase 2 0.668
ALPP alkaline phosphatase, placental 0.663
LRR1 leucine rich repeat protein 1 0.662
RPA4 replication protein A4, 30kDa 0.661
GUF1 GUF1 GTPase homolog (S. cerevisiae) 0.66
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.658
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.657
POU3F1 POU class 3 homeobox 1 0.653
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 0.65
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.65
F8A1 coagulation factor VIII-associated 1 0.649
ERV3-1 endogenous retrovirus group 3, member 1 0.647
ERVFRD-1 endogenous retrovirus group FRD, member 1 0.644
HSPA4 heat shock 70kDa protein 4 0.642
PARPBP PARP1 binding protein 0.639
IPO4 importin 4 0.639
PNPO pyridoxamine 5'-phosphate oxidase 0.638
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 0.637
ERVW-1 endogenous retrovirus group W, member 1 0.636
GTF2H5 general transcription factor IIH, polypeptide 5 0.636
PACC1 proton activated chloride channel 1 0.635
REC114 REC114 meiotic recombination protein 0.633
CDKN3 cyclin-dependent kinase inhibitor 3 0.631
EXOSC10 exosome component 10 0.63
CFP complement factor properdin 0.628
INIP INTS3 and NABP interacting protein 0.627
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.626
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 0.626
FBXO6 F-box protein 6 0.625
CCKAR cholecystokinin A receptor 0.625
MRRF mitochondrial ribosome recycling factor 0.623
UBA1 ubiquitin-like modifier activating enzyme 1 0.622
ZNF629 zinc finger protein 629 0.622
ZNF501 zinc finger protein 501 0.621
ZNF763 zinc finger protein 763 0.621
ZNF44 zinc finger protein 44 0.621
ZNF436 zinc finger protein 436 0.62
H2AZ2 H2A.Z variant histone 2 0.62
CNOT9 CCR4-NOT transcription complex subunit 9 0.617
SHLD1 shieldin complex subunit 1 0.617
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.615
DOCK11 dedicator of cytokinesis 11 0.615
ATXN7 ataxin 7 0.613
TG thyroglobulin 0.612
TPTE transmembrane phosphatase with tensin homology 0.61
PSG5 pregnancy specific beta-1-glycoprotein 5 0.609
MAPK15 mitogen-activated protein kinase 15 0.609
EXD2 exonuclease 3'-5' domain containing 2 0.608
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.607
SPNS1 spinster homolog 1 (Drosophila) 0.606
UCK1 uridine-cytidine kinase 1 0.606
UBE2S ubiquitin-conjugating enzyme E2S 0.603
ASCC1 activating signal cointegrator 1 complex subunit 1 0.601
CD200 CD200 molecule 0.601
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.6
SPIDR scaffolding protein involved in DNA repair 0.6
ASCC3 activating signal cointegrator 1 complex subunit 3 0.597
EP400 E1A binding protein p400 0.597
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.596
PRPF19 pre-mRNA processing factor 19 0.594
SYCE1L synaptonemal complex central element protein 1-like 0.594
CCDC82 coiled-coil domain containing 82 0.593
MACROH2A1 macroH2A.1 histone 0.593
KDM4D lysine (K)-specific demethylase 4D 0.592
ASPH aspartate beta-hydroxylase 0.591
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.59
SETDB1 SET domain, bifurcated 1 0.589
ACRV1 acrosomal vesicle protein 1 0.587
SPAST spastin 0.587
CTBP1 C-terminal binding protein 1 0.585
AURKA aurora kinase A 0.584
PARP14 poly (ADP-ribose) polymerase family, member 14 0.584
UCKL1 uridine-cytidine kinase 1-like 1 0.583
ZBTB1 zinc finger and BTB domain containing 1 0.583
TET2 tet methylcytosine dioxygenase 2 0.582
GLYAT glycine-N-acyltransferase 0.581
NRDC nardilysin convertase 0.58
ETF1 eukaryotic translation termination factor 1 0.58
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.579
PIAS4 protein inhibitor of activated STAT, 4 0.579
RPAIN RPA interacting protein 0.577
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.576
BABAM1 BRISC and BRCA1 A complex member 1 0.576
RPL34 ribosomal protein L34 0.573
KANSL1 KAT8 regulatory NSL complex subunit 1 0.573
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 0.572
MYRF myelin regulatory factor 0.57
RAD51D RAD51 paralog D 0.57
CCND1 cyclin D1 0.57
PHF20 PHD finger protein 20 0.569
CDK4 cyclin-dependent kinase 4 0.569
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 0.568
SIX1 SIX homeobox 1 0.567
PMPCB peptidase (mitochondrial processing) beta 0.567
SWI5 SWI5 recombination repair homolog (yeast) 0.566
ASCC2 activating signal cointegrator 1 complex subunit 2 0.565
MTFMT mitochondrial methionyl-tRNA formyltransferase 0.564
UBD ubiquitin D 0.563
ERCC8 excision repair cross-complementation group 8 0.562
PDPN podoplanin 0.562
ZWINT ZW10 interacting kinetochore protein 0.561
RPLP1 ribosomal protein, large, P1 0.56
CCNE2 cyclin E2 0.56
RPGR retinitis pigmentosa GTPase regulator 0.557
SPATA46 spermatogenesis associated 46 0.557
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.556
UBE2A ubiquitin-conjugating enzyme E2A 0.555
DAXX death-domain associated protein 0.555
LRRC14 leucine rich repeat containing 14 0.554
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.554
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.552
PHF2 PHD finger protein 2 0.552
ISOC2 isochorismatase domain containing 2 0.55
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.55
PMPCA peptidase (mitochondrial processing) alpha 0.549
NMT1 N-myristoyltransferase 1 0.548
TMC6 transmembrane channel-like 6 0.548
PYDC1 PYD (pyrin domain) containing 1 0.546
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.546
SRCIN1 SRC kinase signaling inhibitor 1 0.545
ZNF544 zinc finger protein 544 0.543
ZCCHC3 zinc finger, CCHC domain containing 3 0.543
TCP1 t-complex 1 0.543
PSMC3IP PSMC3 interacting protein 0.542
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.541
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.541
SERINC3 serine incorporator 3 0.539
DLL3 delta-like 3 (Drosophila) 0.537
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa 0.537
ATN1 atrophin 1 0.537
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) 0.536
PIH1D1 PIH1 domain containing 1 0.536
RAN RAN, member RAS oncogene family 0.535
HMHB1 histocompatibility (minor) HB-1 0.534
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 0.533
YBX2 Y box binding protein 2 0.533
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.531
CKB creatine kinase, brain 0.53
ACR acrosin 0.529
DNTT DNA nucleotidylexotransferase 0.529
TTC1 tetratricopeptide repeat domain 1 0.528
XAB2 XPA binding protein 2 0.528
ZNF280C zinc finger protein 280C 0.525
PKM pyruvate kinase, muscle 0.523
CNOT1 CCR4-NOT transcription complex, subunit 1 0.523
ENDOU endonuclease, polyU-specific 0.522
CCNE1 cyclin E1 0.522
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.522
STAG2 stromal antigen 2 0.522
SKIC2 SKI2 subunit of superkiller complex 0.519
BABAM2 BRISC and BRCA1 A complex member 2 0.512
ZNF3 zinc finger protein 3 0.51
SMG7 SMG7 nonsense mediated mRNA decay factor 0.51
SLC25A46 solute carrier family 25, member 46 0.508
E2F4 E2F transcription factor 4, p107/p130-binding 0.508
TERT telomerase reverse transcriptase 0.506
PNKD paroxysmal nonkinesigenic dyskinesia 0.505
CCDC90B coiled-coil domain containing 90B 0.505
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.505
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial 0.505
LRWD1 leucine-rich repeats and WD repeat domain containing 1 0.504
MEPCE methylphosphate capping enzyme 0.501
PIAS1 protein inhibitor of activated STAT, 1 0.5