DNA repair pathways full network Gene Set

Dataset WikiPathways Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://www.wikipathways.org/pathways/WP4946.html
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120 proteins participating in the DNA repair pathways full network pathway from the WikiPathways Pathways 2024 dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CCNH cyclin H
CDK7 cyclin-dependent kinase 7
CENPS centromere protein S
CENPX centromere protein X
CETN2 centrin, EF-hand protein, 2
CHEK1 checkpoint kinase 1
CUL4A cullin 4A
CUL4B cullin 4B
DCLRE1C DNA cross-link repair 1C
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERCC8 excision repair cross-complementation group 8
EXO1 exonuclease 1
FAAP100 FA core complex associated protein 100
FAAP24 FA core complex associated protein 24
FAN1 FANCD2/FANCI-associated nuclease 1
FANCA Fanconi anemia, complementation group A
FANCB Fanconi anemia, complementation group B
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FANCM Fanconi anemia, complementation group M
FEN1 flap structure-specific endonuclease 1
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa
GTF2H2C GTF2H2 family member C
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GTF2H5 general transcription factor IIH, polypeptide 5
H2AX H2A.X variant histone
HMGB1 high mobility group box 1
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
MBD4 methyl-CpG binding domain protein 4
MGMT O-6-methylguanine-DNA methyltransferase
MLH1 mutL homolog 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPG N-methylpurine-DNA glycosylase
MRE11 MRE11 homolog, double strand break repair nuclease
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MUTYH mutY homolog
NBN nibrin
NEIL2 nei endonuclease VIII-like 2 (E. coli)
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NHEJ1 nonhomologous end-joining factor 1
NTHL1 nth endonuclease III-like 1 (E. coli)
OGG1 8-oxoguanine DNA glycosylase
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNKP polynucleotide kinase 3'-phosphatase
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLD3 polymerase (DNA-directed), delta 3, accessory subunit
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit
POLH polymerase (DNA directed), eta
POLI polymerase (DNA directed) iota
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD23A RAD23 homolog A (S. cerevisiae)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RAD52 RAD52 homolog (S. cerevisiae)
RAD54B RAD54 homolog B (S. cerevisiae)
RAP1A RAP1A, member of RAS oncogene family
RBX1 ring-box 1, E3 ubiquitin protein ligase
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC1 replication factor C (activator 1) 1, 145kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
TDG thymine-DNA glycosylase
TERF2 telomeric repeat binding factor 2
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
WDR48 WD repeat domain 48
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6