DNAJC2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description DnaJ (Hsp40) homolog, subfamily C, member 2|This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 27000)
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Genes

294 genes differentially expressed following the DNAJC2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
RGS8 regulator of G-protein signaling 8 2.47444
CCN5 cellular communication network factor 5 2.47444
TLCD3A TLC domain containing 3A 2.47444
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.47444
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.47444
C11ORF87 chromosome 11 open reading frame 87 2.47444
ANXA13 annexin A13 2.47444
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.47444
LEP leptin 2.47444
ADAM32 ADAM metallopeptidase domain 32 2.47444
BDKRB2 bradykinin receptor B2 2.47444
MEIKIN meiotic kinetochore factor 2.47444
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.47444
SLC38A8 solute carrier family 38, member 8 2.47444
WNT3A wingless-type MMTV integration site family, member 3A 2.47444
FAM216B family with sequence similarity 216, member B 2.47444
LGI1 leucine-rich, glioma inactivated 1 2.47444
PLGLB2 plasminogen-like B2 2.47444
GJB6 gap junction protein, beta 6, 30kDa 2.47444
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.47444
TSPAN16 tetraspanin 16 2.47444
S100A1 S100 calcium binding protein A1 2.47444
CLTC clathrin, heavy chain (Hc) 2.47236
SPATA12 spermatogenesis associated 12 2.47236
ZNF662 zinc finger protein 662 2.37844
MGAM2 maltase-glucoamylase 2 (putative) 2.37844
TEX13A testis expressed 13A 2.37844
PGAM4 phosphoglycerate mutase family member 4 2.37844
SLC22A10 solute carrier family 22, member 10 2.37844
CELF6 CUGBP, Elav-like family member 6 2.37844
TAS2R3 taste receptor, type 2, member 3 2.37844
COL4A4 collagen, type IV, alpha 4 2.37844
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.37844
KLHL34 kelch-like family member 34 2.37844
UNC13C unc-13 homolog C (C. elegans) 2.37844
TMEM82 transmembrane protein 82 2.37844
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like 2.37844
C1ORF146 chromosome 1 open reading frame 146 2.37844
PCDH8 protocadherin 8 2.37844
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.37844
PTGFR prostaglandin F receptor (FP) 2.37844
LOC124901872 uncharacterized LOC124901872 2.37844
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.37844
TUBB8 tubulin, beta 8 class VIII 2.37844
OR51A4 olfactory receptor, family 51, subfamily A, member 4 2.37844
TYRP1 tyrosinase-related protein 1 2.37844
WT1 Wilms tumor 1 2.37844
SKOR2 SKI family transcriptional corepressor 2 2.37844
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.37844
IQCC IQ motif containing C 2.37844
LYZL6 lysozyme-like 6 2.37844
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.37844
RGS9BP regulator of G protein signaling 9 binding protein 2.37844
FIMP1 fertilization-influencing membrane protein 1 2.37844
ACER1 alkaline ceramidase 1 2.37844
ADGRG7 adhesion G protein-coupled receptor G7 2.37844
GPR35 G protein-coupled receptor 35 2.37844
AVPR1B arginine vasopressin receptor 1B 2.37844
ARX aristaless related homeobox 2.37844
GIPC3 GIPC PDZ domain containing family, member 3 2.37844
SPATS1 spermatogenesis associated, serine-rich 1 2.37844
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 2.37844
HAPSTR1 HUWE1 associated protein modifying stress responses 2.37844
CBY2 chibby family member 2 2.37844
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.37844
ARMH2 armadillo like helical domain containing 2 2.37844
TMEM238L transmembrane protein 238 like 2.37844
TMA7B translation machinery associated 7 homolog B 2.37844
SPMIP3 sperm microtubule inner protein 3 2.37844
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.37844
TEX261 testis expressed 261 2.37844
LIPF lipase, gastric 2.37844
SLFN14 schlafen family member 14 2.37844
PCDHA7 protocadherin alpha 7 2.37844
OASL 2'-5'-oligoadenylate synthetase-like 2.37844
CCNG1 cyclin G1 2.37844
C3ORF80 chromosome 3 open reading frame 80 2.37844
MIP major intrinsic protein of lens fiber 2.37844
C1QL2 complement component 1, q subcomponent-like 2 2.37844
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.37844
SPDYC speedy/RINGO cell cycle regulator family member C 2.37844
PRR4 proline rich 4 (lacrimal) 2.37844
PTH parathyroid hormone 2.37844
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.37844
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.37844
KL klotho 2.37844
FAM228A family with sequence similarity 228, member A 2.37844
TEX53 testis expressed 53 2.37844
NPY2R neuropeptide Y receptor Y2 2.37844
ZNF628 zinc finger protein 628 2.37844
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.37844
AQP6 aquaporin 6, kidney specific 2.37844
CST7 cystatin F (leukocystatin) 2.37844
ZNF709 zinc finger protein 709 2.37844
PRF1 perforin 1 (pore forming protein) 2.37844
APOB apolipoprotein B 2.37844
C10ORF120 chromosome 10 open reading frame 120 2.37844
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.37844
FZD1 frizzled class receptor 1 2.37844
MC5R melanocortin 5 receptor 2.37844
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.37844
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.37844
EPO erythropoietin 2.37844
GLTPD2 glycolipid transfer protein domain containing 2 2.37844
CD80 CD80 molecule 2.37844
NPFFR1 neuropeptide FF receptor 1 2.37844
NPBWR1 neuropeptides B/W receptor 1 2.37844
SFTA2 surfactant associated 2 2.37844
LAMB3 laminin, beta 3 2.37844
ESPNL espin-like 2.37844
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.37844
TYR tyrosinase 2.37844
PSG3 pregnancy specific beta-1-glycoprotein 3 2.37844
ITGAD integrin, alpha D 2.37844
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 2.37844
PLA2G12B phospholipase A2, group XIIB 2.37844
TF transferrin 2.37844
CHIT1 chitinase 1 (chitotriosidase) 2.37844
RORC RAR-related orphan receptor C 2.37844
HOPX HOP homeobox 2.37844
HRCT1 histidine rich carboxyl terminus 1 2.37844
TEKT2 tektin 2 (testicular) 2.37844
MAMLD1 mastermind-like domain containing 1 2.37844
GPR12 G protein-coupled receptor 12 2.37844
IL2RG interleukin 2 receptor, gamma 2.37844
CD3D CD3d molecule, delta (CD3-TCR complex) 2.37844
STAP1 signal transducing adaptor family member 1 2.37844
SPDEF SAM pointed domain containing ETS transcription factor 2.37844
RNASE7 ribonuclease, RNase A family, 7 2.37844
ERAP2 endoplasmic reticulum aminopeptidase 2 2.37844
PRDM12 PR domain containing 12 2.37844
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.37844
NWD2 NACHT and WD repeat domain containing 2 2.37844
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.37844
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.37844
HIC1 hypermethylated in cancer 1 2.37844
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.37844
CPLX3 complexin 3 2.37844
CORO6 coronin 6 2.37844
ABRA actin binding Rho activating protein 2.37844
ADRA1B adrenoceptor alpha 1B 2.37844
FOXP3 forkhead box P3 2.37844
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.37844
IL37 interleukin 37 2.37844
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.37844
PADI1 peptidyl arginine deiminase, type I 2.37844
KRTAP9-3 keratin associated protein 9-3 2.37844
NNAT neuronatin 2.37594
CDO1 cysteine dioxygenase type 1 2.36649
GULP1 GULP, engulfment adaptor PTB domain containing 1 2.28682
PDLIM5 PDZ and LIM domain 5 2.28584
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 2.25316
CNGA4 cyclic nucleotide gated channel alpha 4 2.24464
ARSB arylsulfatase B 2.24218
LINGO1 leucine rich repeat and Ig domain containing 1 2.23705
IL1RAP interleukin 1 receptor accessory protein 2.23705
SLC39A3 solute carrier family 39 (zinc transporter), member 3 2.23705
F11 coagulation factor XI 2.23437
OTX1 orthodenticle homeobox 1 2.23437
ADGRD1 adhesion G protein-coupled receptor D1 2.23437
TSPYL1 TSPY-like 1 2.23013
GDAP2 ganglioside induced differentiation associated protein 2 2.22539
SAR1B secretion associated, Ras related GTPase 1B 2.20752
TRAPPC3 trafficking protein particle complex 3 2.20481
RFTN2 raftlin family member 2 2.15058
FUT2 fucosyltransferase 2 (secretor status included) 2.14879
CRTC1 CREB regulated transcription coactivator 1 2.12127
CRTAP cartilage associated protein 2.10608
MCTS1 malignant T cell amplified sequence 1 2.07952
GPR27 G protein-coupled receptor 27 2.07952
CASP9 caspase 9, apoptosis-related cysteine peptidase 2.07575
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 2.05552
MYO6 myosin VI 2.05016
PNRC1 proline-rich nuclear receptor coactivator 1 2.02703
RSAD1 radical S-adenosyl methionine domain containing 1 2.02695
LMBRD2 LMBR1 domain containing 2 2.02555
ERCC1 excision repair cross-complementation group 1 2.01171
TMEM230 transmembrane protein 230 2.00695
TMEM143 transmembrane protein 143 2.00655
PARP12 poly (ADP-ribose) polymerase family, member 12 2.0003
MMP24OS MMP24 opposite strand 2.0003
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 2.0003

decreased expression

Symbol Name Standardized Value
ZNF98 zinc finger protein 98 -2.47444
S100PBP S100P binding protein -2.47444
ANKDD1B ankyrin repeat and death domain containing 1B -2.47444
PKD1L3 polycystic kidney disease 1-like 3 -2.47444
MPPED1 metallophosphoesterase domain containing 1 -2.47444
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.47444
TRIM36 tripartite motif containing 36 -2.44498
CYCS cytochrome c, somatic -2.4407
IL15RA interleukin 15 receptor, alpha -2.40493
PNMA8C PNMA family member 8C -2.37844
DNAH2 dynein, axonemal, heavy chain 2 -2.37844
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -2.37844
ZBTB6 zinc finger and BTB domain containing 6 -2.37844
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E -2.37844
HACD4 3-hydroxyacyl-CoA dehydratase 4 -2.37844
GLUD1 glutamate dehydrogenase 1 -2.37844
ETV7 ets variant 7 -2.37844
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -2.37844
ZBTB47 zinc finger and BTB domain containing 47 -2.37844
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 -2.37844
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.37844
BIRC6 baculoviral IAP repeat containing 6 -2.37844
VIPR2 vasoactive intestinal peptide receptor 2 -2.37844
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -2.37844
CPNE4 copine IV -2.37844
CFAP276 cilia and flagella associated protein 276 -2.37844
RNF227 ring finger protein 227 -2.37844
H2BC5 H2B clustered histone 5 -2.37844
LOC112694756 uncharaterized LOC112694756 -2.37844
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.37844
MYZAP myocardial zonula adherens protein -2.37844
NHLH1 nescient helix loop helix 1 -2.37844
LY6K lymphocyte antigen 6 complex, locus K -2.37844
SH3BP2 SH3-domain binding protein 2 -2.37844
DYNAP dynactin associated protein -2.37844
COG1 component of oligomeric golgi complex 1 -2.37844
SUMO4 small ubiquitin-like modifier 4 -2.37844
AXDND1 axonemal dynein light chain domain containing 1 -2.37844
IRF4 interferon regulatory factor 4 -2.37844
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.37844
TMEM229A transmembrane protein 229A -2.37844
CCDC194 coiled-coil domain containing 194 -2.37844
ASCL3 achaete-scute family bHLH transcription factor 3 -2.37844
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -2.37844
EXOSC9 exosome component 9 -2.37844
CTXN1 cortexin 1 -2.37844
BATF2 basic leucine zipper transcription factor, ATF-like 2 -2.37844
APOM apolipoprotein M -2.37844
TEKT3 tektin 3 -2.37844
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -2.37844
ZNF132 zinc finger protein 132 -2.37844
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -2.37844
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -2.37844
BTNL9 butyrophilin-like 9 -2.37844
CDYL chromodomain protein, Y-like -2.37844
CD248 CD248 molecule, endosialin -2.37844
ZNF626 zinc finger protein 626 -2.37844
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 -2.37844
TICAM1 toll-like receptor adaptor molecule 1 -2.37844
PAGE4 P antigen family, member 4 (prostate associated) -2.37844
PFN2 profilin 2 -2.37844
CXCR5 chemokine (C-X-C motif) receptor 5 -2.37844
PPP1R3F protein phosphatase 1, regulatory subunit 3F -2.37844
C17ORF78 chromosome 17 open reading frame 78 -2.37844
INSL3 insulin-like 3 (Leydig cell) -2.37844
DAW1 dynein assembly factor with WDR repeat domains 1 -2.37844
CFB complement factor B -2.37844
KCNK15 potassium channel, two pore domain subfamily K, member 15 -2.37844
C6ORF62 chromosome 6 open reading frame 62 -2.33848
ZNF829 zinc finger protein 829 -2.31779
H4C11 H4 clustered histone 11 -2.31779
FANK1 fibronectin type III and ankyrin repeat domains 1 -2.26923
MINPP1 multiple inositol-polyphosphate phosphatase 1 -2.26677
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -2.24218
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.21795
MGST1 microsomal glutathione S-transferase 1 -2.21716
PDGFC platelet derived growth factor C -2.21607
ATF6B activating transcription factor 6 beta -2.21607
AASS aminoadipate-semialdehyde synthase -2.20488
POLR1C polymerase (RNA) I polypeptide C, 30kDa -2.19715
FAT2 FAT atypical cadherin 2 -2.19481
PCDH7 protocadherin 7 -2.19481
TXNDC15 thioredoxin domain containing 15 -2.19481
NEU1 sialidase 1 (lysosomal sialidase) -2.19481
TRIM68 tripartite motif containing 68 -2.14879
ZNF326 zinc finger protein 326 -2.13854
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.12127
PIAS4 protein inhibitor of activated STAT, 4 -2.12127
TUBB3 tubulin, beta 3 class III -2.11896
CFAP221 cilia and flagella associated protein 221 -2.1155
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.11014
SEPTIN5 septin 5 -2.10608
TMOD1 tropomodulin 1 -2.10608
JAKMIP1 janus kinase and microtubule interacting protein 1 -2.10608
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 -2.10608
MCM3 minichromosome maintenance complex component 3 -2.07575
H2AJ H2A.J histone -2.05819
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) -2.05724
SASS6 spindle assembly 6 homolog (C. elegans) -2.05386
SNAI1 snail family zinc finger 1 -2.05386
RPSA ribosomal protein SA -2.03414
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.02836
PHF8 PHD finger protein 8 -2.02555
SLC16A13 solute carrier family 16, member 13 -2.02555
UPP1 uridine phosphorylase 1 -2.01851
BOC BOC cell adhesion associated, oncogene regulated -2.01779
STK40 serine/threonine kinase 40 -2.01485
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -2.01464
PEBP1 phosphatidylethanolamine binding protein 1 -2.01284
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 -2.01126
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.01126
CCDC60 coiled-coil domain containing 60 -2.01126